ARTICLE: Low High-Density Lipoprotein Cholesterol and Incident Coronary Heart Among Blacks in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study

AUTHORS: Lisandro Colantonio, Sergio Fazio, Robert Rosenson, Michael Miller, Maciej Banach, Monika Safford, Paul Muntner, Peter Toth

JOURNAL: J Am Coll Cardiol. 2016;67(13_S):1837-1837. doi:10.1016/S0735-1097(16)31838-1


Background: Low high-density lipoprotein cholesterol (HDL-C) has been associated with incident coronary heart disease (CHD) in many

studies; however, most of these studies analyzed predominantly white populations. We examined the association of low HDL-C with incident CHD among black adults in a large population-based US cohort.

Methods: We analyzed data from black men and women ≥45 years of age without a history of CHD enrolled in the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study from 2003 to 2007. Participants were included in the analysis if they had valid measurements of HDL-C, low-density lipoprotein cholesterol (LDL-C) and triglycerides at baseline (n=8,156). Low HDL-C was defined as HDL-C <40 mg/dL in men or <50 mg/dL in women. Incident CHD (MI or CHD death) was adjudicated through December 2012. Analyses were stratified by levels of LDL-C and triglycerides.

Results: There were a total of 350 incident CHD events over a median follow-up of 6.8 years. After adjustment for age, gender and region of residence, low HDL-C was associated with higher risk for CHD only among participants with LDL-C ≥100 mg/dL and triglycerides <100 mg/dL (Table). Low HDL-C was not independently associated with incident CHD after further adjustment for risk factors regardless the levels of LDL-C and triglycerides.

Conclusions: After adjustment for cardiovascular risk factors, low HDL-C was not associated with incident CHD in a large population-based cohort of blacks.

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