ARTICLE: Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis AUTHORS: Michael A. Koldobskiy, Garrett Jenkinson, Jordi Abante, Varenka A. Rodriguez DiBlasi, Weiqiang Zhou, Elisabet Pujadas, Adrian Idrizi, Rakel Tryggvadottir, Colin Callahan, Challice L. Bonifant, Karen R. Rabin, Patrick A. Brown, Hongkai Ji, John Goutsias & Andrew P. Feinberg JOURNAL: Nat Biomed Eng. 2021 Apr;5(15): 360–376. doi: 10.1038/s41551-021-00703-2 Abstract In cancer, linking epigenetic alterations to […]
Article of the Week
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak
Posted by | Article of the WeekARTICLE: MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak AUTHORS: Ting Liu, Ni Yang, Agnieszka Sidor, Brian O’Rourke JOURNAL: Circ Res. 2021 Apr 16;128(8):1191-1204. doi: 10.1161/CIRCRESAHA.120.318562. Epub 2021 Feb 1. Abstract Rationale: In heart failure (HF), impaired sarcoplasmic reticulum (SR) Ca2+ release and cytosolic Na+ overload depress mitochondrial Ca2+ (mCa2+) signaling, resulting in a diminished ability to maintain matrix NAD(P)H […]
The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial
Posted by | Article of the WeekAUTHORS: Lawrence J Appel, Erin D Michos, Christine M Mitchell, Amanda L Blackford, Alice L Sternberg, Edgar R Miller 3rd, Stephen P Juraschek, Jennifer A Schrack, Sarah L Szanton, Jeanne Charleston, Melissa Minotti, Sheriza N Baksh, Robert H Christenson, Josef Coresh, Lea T Drye, Jack M Guralnik, Rita R Kalyani, Timothy B Plante, David M Shade, David L Roth, James Tonascia JOURNAL: Ann Intern Med. 2021 Feb;174(2):145-156. doi: 10.7326/M20-3812. Epub 2020 Dec 8. Abstract Background: Vitamin D supplementation may […]
Myocardial Injury in Severe COVID-19 Compared With Non-COVID-19 Acute Respiratory Distress Syndrome
Posted by | Article of the WeekARTICLE: Myocardial Injury in Severe COVID-19 Compared With Non-COVID-19 Acute Respiratory Distress Syndrome AUTHORS: Thomas S Metkus, Lori J Sokoll, Andreas S Barth, Matthew J Czarny, Allison G Hays, Charles J Lowenstein, Erin D Michos, Eric P Nolley, Wendy S Post, Jon R Resar, David R Thiemann, Jeffrey C Trost, Rani K Hasan JOURNAL: Circulation. 2021 Feb 9;143(6):553-565. doi: 10.1161/CIRCULATIONAHA.120.050543. Epub 2020 Nov 13. Abstract Background: Knowledge gaps remain in […]
Operational Recommendations for Scarce Resource Allocation in a Public Health Crisis
Posted by | Article of the WeekARTICLE: Operational Recommendations for Scarce Resource Allocation in a Public Health Crisis AUTHORS: Michael R Ehmann, Elizabeth K Zink, Amanda B Levin, Jose I Suarez, Harolyn M E Belcher, Elizabeth L Daugherty Biddison, Danielle J Doberman, Karen D'Souza, Derek M Fine, Brian T Garibaldi, Eric A Gehrie, Sherita H Golden, Ayse P Gurses, Peter M Hill, Mark T Hughes, Jeffrey P Kahn, Colleen G Koch, Jason J Marx, Barry R […]
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
Posted by | Article of the WeekARTICLE: PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 AUTHORS: Sean A Murphy, Matthew Miyamoto, Anaïs Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S An, David A Kass, Hideki Uosaki, Alexandre R Colas, Chulan Kwon JOURNAL: Nat Commun. 2021 Mar 12;12(1):1648. doi: 10.1038/s41467-021-21957-z. Abstract Cardiomyocytes undergo significant structural and functional changes after birth, and these fundamental […]
Dolutegravir-based Antiretroviral Therapy for Patients Coinfected With Tuberculosis and Human Immunodeficiency Virus: A Multicenter, Noncomparative, Open-label, Randomized Trial
Posted by | Article of the WeekARTICLE: Dolutegravir-based Antiretroviral Therapy for Patients Coinfected With Tuberculosis and Human Immunodeficiency Virus: A Multicenter, Noncomparative, Open-label, Randomized Trial AUTHORS: Kelly E Dooley, Richard Kaplan, Noluthando Mwelase, Beatriz Grinsztejn, Eduardo Ticona, Marcus Lacerda, Omar Sued, Elena Belonosova, Mounir Ait-Khaled, Konstantinos Angelis, Dannae Brown, Rajendra Singh, Christine L Talarico, Allan R Tenorio, Michael R Keegan, Michael Aboud, International Study of Patients with HIV on Rifampicin ING study group JOURNAL: Clin Infect […]
Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes
Posted by | Article of the WeekARTICLE: Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes AUTHORS: Marie-Pierre St-Onge, Brooke Aggarwal, Matthew A Allison, Jeffrey S Berger, Sheila F Castañeda, Janet Catov, Judith S Hochman, Carl A Hubel, Sanja Jelic, David A Kass, Nour Makarem, Erin D Michos, Lori Mosca, Pamela Ouyang, Chorong Park, Wendy S Post, Robert W Powers, Harmony R Reynolds, Dorothy D Sears, Sanjiv J Shah, Kavita Sharma, Tanya Spruill, Gregory A Talavera, Dhananjay Vaidya JOURNAL: […]
Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C-Viremic Donors to Hepatitis C-Negative Recipients: An Open-Label Nonrandomized Study
Posted by | Article of the WeekARTICLE: Four-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Hepatitis C-Viremic Donors to Hepatitis C-Negative Recipients: An Open-Label Nonrandomized Study AUTHORS: Christine M Durand, Brittany Barnaba, Sile Yu, Diane M Brown, Michael A Chattergoon, Nichole Bair, Fizza F Naqvi, Mark Sulkowski, Dorry L Segev, Niraj M Desai JOURNAL: Ann Intern Med. 2021 Jan;174(1):137-138. doi: 10.7326/M20-1468. Epub 2020 Sep 8. Abstract Background: Kidneys from deceased donors with hepatitis C […]
Once-weekly rifapentine and isoniazid for tuberculosis prevention in patients with HIV taking dolutegravir-based antiretroviral therapy: a phase 1/2 trial
Posted by | Article of the WeekARTICLE: Once-weekly rifapentine and isoniazid for tuberculosis prevention in patients with HIV taking dolutegravir-based antiretroviral therapy: a phase 1/2 trial AUTHORS: Kelly E Dooley, Radojkam Savic, Akshay Gupte, Mark A Marzinke, Nan Zhang, Vinodh A Edward, Lisa Wolf, Modulakgotla Sebe, Morongwe Likoti, Mark J Fyvie, Innocent Shibambo, Trevor Beattie, Richard E Chaisson, Gavin J Churchyard, DOLPHIN Study Team JOURNAL: Lancet HIV. 2020 Jun;7(6):e401-e409. doi: 10.1016/S2352-3018(20)30032-1. Epub 2020 Mar 30. Abstract Background: Short-course preventive […]