Article of the Week

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

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ARTICLE: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress AUTHORS: Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee & David A. Kass JOURNAL: Nature. 2019 Jan 30. doi: 10.1038/s41586-019-0895-y. [Epub ahead of print] Brief Summary Protein kinase G has long been considered to provide protection against(...)

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Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study

Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study

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ARTICLE: Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study AUTHORS: Zhixiong Wang, Swetha Kambhampati, Yulan Cheng, Ke Ma, Cem Simsek, Alan H Tieu, John M Abraham, Xi Liu, Vishnu Prasath, Mark D Duncan, Alejandro Stark, Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He, Mouen A Khashab, Saowanee Ngamruengphong, Eun J Shin, Tza-Huei Wang and Stephen J. Meltzer JOURNAL: Clin Cancer Res. 2019 Jan 22. pii: clincanres.3696.2018. doi: 10.1158/1078-0432.CCR-18-3696. [Epub ahead of print] Abstract PURPOSE: Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma (EAC). Although endoscopy and biopsy(...)

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Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use

Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use

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ARTICLE: Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use AUTHORS: Alexandra T. Strauss, Theodore W. James and Simon C. Mathews JOURNAL: Gastroenterology. 2018 Dec;155(6):2014-2015. doi: 10.1053/j.gastro.2018.08.034. Epub 2018 Aug 27. The number and complexity of procedures performed by gastroenterologists are increasing in the United States. In addition, the(...)

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Substance-Use Disorders in Later Life

Substance-Use Disorders in Later Life

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ARTICLE: Substance-Use Disorders in Later Life AUTHORS: Susan W. Lehmann and Michael Fingerhood JOURNAL: NEJM. 2018 Dec 13.doi: 10.1056/NEJMra1805981 Substance-use disorders have been declared a national public health emergency.1 Although the rates of substance use are generally lower among older adults than among younger people, this review focuses on older adults.2 Physiological changes in hepatic metabolism that occur(...)

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Rural Residence and Poverty are Independent Risk Factors for COPD in the United States

Rural Residence and Poverty are Independent Risk Factors for COPD in the United States

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ARTICLE: Rural Residence and Poverty are Independent Risk Factors for COPD in the United States AUTHORS: Sarath Raju, Corinne A Keet, Laura M Paulin, Elizabeth C Matsui, Roger D Peng, Nadia N Hansel and Meredith C McCormack JOURNAL: Am J Respir Crit Care Med. 2018 Nov 2. doi: 10.1164/rccm.201807-1374OC. [Epub ahead of print] Abstract RATIONALE: In developing countries, poor and rural areas have a(...)

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Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

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ARTICLE: Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner? AUTHORS: Thomaz Fleury Curado, Slava Berger and Vsevolod Y Polotsky JOURNAL: Am J Respir Crit Care Med. 2018 Dec 6. doi: 10.1164/rccm.201811-2135ED. [Epub ahead of print] Obstructive sleep apnea (OSA) is recurrent upper airway obstruction caused by a loss of upper airway muscle tone during sleep, which(...)

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Long-term remission despite clonal expansion of replication-competent HIV-1 isolates

Long-term remission despite clonal expansion of replication-competent HIV-1 isolates

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ARTICLE: Long-term remission despite clonal expansion of replication-competent HIV-1 isolates AUTHORS: Rebecca T. Veenhuis, Abena K. Kwaa, Caroline C. Garliss, Rachel Latanich, Maria Salgado, Christopher W. Pohlmeyer, Christopher L. Nobles, John Gregg, Eileen P. Scully, Justin R. Bailey, Frederic D. Bushman and Joel N. Blankson JOURNAL: JCI Insight. 2018 Sep 20;3(18). pii: 122795. doi: 10.1172/jci.insight.122795. [Epub ahead of print] Abstract Clonal expansion of T cells harboring replication-competent virus has recently been demonstrated(...)

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Trends in Mortality From Valvular Heart Disease in Europe From 2001-2015

Trends in Mortality From Valvular Heart Disease in Europe From 2001-2015

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ARTICLE: Trends in Mortality From Valvular Heart Disease in Europe From 2001-2015 AUTHORS: Chike C Nwabuo, Queen N Aghaji, Binu Philips, Joseph Shalhoub, Dominic Marshall and Justin D Salciccioli JOURNAL: 5 Nov 2018Circulation. 2018;138:A15228 Abstract Introduction: Deaths from cardiovascular diseases such as heart failure and coronary artery disease have been declining in developed countries over the(...)

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Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Assembly of a pan-genome from deep sequencing of 910 humans of African descent

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ARTICLE: Assembly of a pan-genome from deep sequencing of 910 humans of African descent AUTHORS: Rachel M. Sherman, Juliet Forman, Valentin Antonescu, Daniela Puiu, Michelle Daya, Nicholas Rafaels, Meher Preethi Boorgula, Sameer Chavan, Candelaria Vergara, Victor E. Ortega, Albert M. Levin, Celeste Eng, Maria Yazdanbakhsh, James G. Wilson, Javier Marrugo, Leslie A. Lange, Keoki Williams, Harold Watson, Lorraine B. Ware, Christopher O. Olopade, Olufunmilayo Olopade, Ricardo R. Oliveira, Carole Ober, Dan L. Nicolae, Deborah A. Meyers, Alvaro Mayorga, Jennifer(...)

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Association of a Care Coordination Model With Health Care Costs and Utilization: The Johns Hopkins Community Health Partnership (J-CHiP)

Association of a Care Coordination Model With Health Care Costs and Utilization: The Johns Hopkins Community Health Partnership (J-CHiP)

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ARTICLE: Association of a Care Coordination Model With Health Care Costs and Utilization: The Johns Hopkins Community Health Partnership (J-CHiP) AUTHORS: Scott A. Berkowitz, Shriram Parashuram, Kathy Rowan, Lindsay Andon, Eric B. Bass, Michele Bellantoni, Daniel J. Brotman, Amy Deutschendorf, Linda Dunbar, Samuel C. Durso, Anita Everett, Katherine D. Giuriceo, Lindsay Hebert, Debra Hickman, Douglas E. Hough, Eric E. Howell, Xuan Huang, Diane Lepley, Curtis Leung, Yanyan Lu, Constantine G. Lyketsos, Shannon M. E. Murphy, Tracy Novak, Leon Purnell, Carol Sylvester, Albert W. Wu, Ray Zollinger, Kevin Koenig, Roy Ahn, Paul B. Rothman, Patricia M. C. Brown, for the Johns Hopkins Community Health Partnership (J-CHiP) Team JOURNAL: JAMA Netw Open. 2018;1(7):e184273. doi:10.1001/jamanetworkopen.2018.4273 Abstract Importance: The Johns Hopkins Community(...)

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