ARTICLE: Recent trends in the incidence and survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results analysis AUTHORS: Amanda L Blackford, Marcia Irene Canto, Alison P Klein, Ralph H Hruban, Michael Goggins JOURNAL: J Natl Cancer Inst. 2020 Jan 20. pii: djaa004. doi: 10.1093/jnci/djaa004. [Epub ahead of print] Abstract BACKGROUND: Rapid access to pancreatic imaging and regular pancreatic surveillance may help identify Stage I pancreatic cancer. We investigated recent trends in the stage of newly-diagnosed PDACs, […]
Article of the Week
Risk Factor Modification Reduces Atrial Fibrillation
Posted by | Article of the WeekARTICLE: Risk Factor Modification Reduces Atrial Fibrillation AUTHORS: Thomas M. Das, Rachit M. Vakil, Roger S. Blumenthal JOURNAL: Circulation. 2020 Mar 9. doi: 10.1161/CIR.0000000000000748. Atrial fibrillation (AF) is the most common sustained arrhythmia, with approximately 5 million new cases diagnosed worldwide each year. The rising incidence of atrial fibrillation is related to the increasing prevalence […]
The Assimilation of International Medical Graduates Into the Cardiovascular Workforce
Posted by | Article of the WeekARTICLE: The Assimilation of International Medical Graduates Into the Cardiovascular Workforce AUTHORS: Arjun Kanwal, Garima Sharma and Elena Surkova JOURNAL: JACC. 2020 Mar. Volume 2, Issue 3 doi: 10.1016/j.jaccas.2020.01.018 The foregoing quotation holds true in the hearts of many immigrants who often navigate troubled waters in hopes of a better future. Traditionally, international medical graduates (IMGs) have immigrated to […]
The Modern Epidemic of Syphilis
Posted by | Article of the WeekARTICLE: The Modern Epidemic of Syphilis AUTHORS: Khalil G. Ghanem, Sanjay Ram and Peter A. Rice JOURNAL: N Engl J Med. 2020 Feb 27;382(9):845-854. doi: 10.1056/NEJMra1901593. Syphilis was first recognized in Europe in the late 15th century1; its cause, Treponema pallidum subspecies pallidum, was identified four centuries later. The advent of penicillin, together with effective public health measures, was […]
Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium
Posted by | Article of the WeekARTICLE: Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium AUTHORS: Michael Goggins, Randall Brand, Sapna Syngal, Marco Del Chiaro, Detlef K Bartsch, Claudio Bassi, Alfredo Carrato, James Farrell, Elliot K Fishman, Paul Fockens, Jeanin E van Hooft, R H Hruban, Fay Kastrinos, […]
Stable ischemic heart disease: how to keep it that way
Posted by | Article of the WeekARTICLE: Stable ischemic heart disease: how to keep it that way AUTHORS: Thorsten M. Leucker, Steven P. Schulman and Gary Gerstenblith JOURNAL: J Clin Invest. 2020 Jan 27. pii: 135959. doi: 10.1172/JCI135959. [Epub ahead of print] Abstract The vast majority of the over 18 million Americans with known coronary atherosclerosis have stable disease (i.e., they do not have nor […]
Association of HLA-DRB1*09:01 with tIgE levels among African ancestry individuals with asthma
Posted by | Article of the WeekARTICLE: Association of HLA-DRB1*09:01 with tIgE levels among African ancestry individuals with asthma AUTHORS: NicolasVince, Sophie Limou, Michelle Daya, Wataru Morii, Nicholas Rafaels, Estelle Geffard, Venceslas Douillard, Alexandre Walencik, Meher Preethi Boorgula, Sameer Chavan, Candelaria Vergara, Victor E.Ortega, James G.Wilson, Leslie A. Lange, Harold Watson, Dan L. Nicolae, Deborah A. Meyers, Nadia N. Hansel, Jean G. Ford, […]
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS
Posted by | Article of the WeekARTICLE: Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS AUTHORS: Shruti Chaturvedi, Evan M. Braunstein, Xuan Yuan, Jia Yu, Alice Alexander, Hang Chen, Eleni Gavriilaki, Ravi Alluri, Michael B. Streiff, Michelle Petri, Mark A. Crowther, Keith R. McCrae, Robert A. Brodsky JOURNAL: Blood. 2020 Jan 23;135(4):239-251. doi: 10.1182/blood.2019003863. Abstract The antiphospholipid syndrome (APS) is characterized by thrombosis and/or […]
Immune Status and Associated Mortality After Cancer Treatment Among Individuals With HIV in the Antiretroviral Therapy Era
Posted by | Article of the WeekARTICLE: Immune Status and Associated Mortality After Cancer Treatment Among Individuals With HIV in the Antiretroviral Therapy Era AUTHORS: Keri L. Calkins, Geetanjali Chander, Corinne E. Joshu, Kala Visvanathan, Anthony T. Fojo, Catherine R. Lesko, Richard D. Moore, Bryan Lau JOURNAL: JAMA Oncol. 2019 Dec 5. doi: 10.1001/jamaoncol.2019.4648. [Epub ahead of print] Abstract IMPORTANCE: Immunologic decline associated with cancer treatment in people with HIV is not well characterized. Quantifying excess mortality associated with cancer treatment-related […]
Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
Posted by | Article of the WeekARTICLE: Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA AUTHORS: Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post and Erin D. Michos JOURNAL: […]