Article of the Week

A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography

A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography

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ARTICLE: A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography AUTHORS: Elizabeth C Oelsner, Victor E Ortega, Benjamin M. Smith, Jennifer N. Nguyen, Ani W Manichaikul, Eric A. Hoffman, Xiuqing Guo, Kent D Taylor, Prescott G Woodruff, David J Couper, Nadia N Hansel, Fernando J. Martinez, Robert Paine III, MeiLan K Han, Christopher Cooper, Mark T Dransfield, Gerard Criner, Jerry A Krishnan, Russell Bowler, Eugene R Bleecker, Stephen Peters, Stephen S.(...)

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Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project

Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project

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ARTICLE: Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project AUTHORS: Seamus P. Whelton, Paul McAuley, Olusola Orimoloye, Erin Michos, Clinton Brawner, Jonathan Ehrman, Steven Keteyian, Mouaz Al-Mallah and Michael Blaha JOURNAL: J Am Coll Cardiol. 2019 Mar 26;73(9). doi: 10.1016/S0735-1097(19)33770-2. Abstract Background: Traditional cardiovascular disease (CVD) risk factors have a decreased predictive(...)

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Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time

Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time

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ARTICLE: Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time AUTHORS: Rhanderson Cardoso, Khurram Nasir, Roger S. Blumenthal, Michael J. Blaha  JOURNAL: Ann Intern Med. 2019 Feb 12. doi: 10.7326/M18-3675. [Epub ahead of print]  The use of traditional risk factors and laboratory markers to estimate 10-year risk(...)

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Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial

Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial

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ARTICLE: Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial AUTHORS: Javier Bolaños-Meade, Kenneth R Cooke, Christopher J Gamper, Syed Abbas Ali, Richard F Ambinder, Ivan M Borrello, Ephraim J Fuchs, Douglas E Gladstone, Christian B Gocke, Carol Ann Huff, Leo Luznik, Lode J Swinnen, Heather J Symons, Stephanie A Terezakis, Nina(...)

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One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis

One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis

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From Bench to Bedside: Animal Model Leads to Novel, 1-month TB Preventive Therapy Identification and treatment of individuals with latent tuberculosis (TB) infection to prevent development of active disease is an essential pillar of the World Health Organization’s End TB Strategy (https://www.who.int/tb/strategy/end-tb/en/). The most widely used regimen to treat latent TB infection currently is a(...)

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Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

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ARTICLE: Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules AUTHORS: Jeffrey H. Silber, Lisa M. Bellini, Judy A. Shea, Sanjay V. Desai, David F. Dinges, Mathias Basner, Orit Even-Shoshan, Alexander S. Hill, Lauren L. Hochman, Joel T. Katz, Richard N. Ross, David M. Shade, Dylan S. Small, Alice L. Sternberg, James Tonascia, Kevin G. Volpp, and David A. Asch for the iCOMPARE Research Group JOURNAL:(...)

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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

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ARTICLE: Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity AUTHORS: Ling Li*, Hildur Knutsdottir, Ken Hui*, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Joel S. Bader and Florin M. Selaru JOURNAL: JCI Insight. 2019 Jan 24;4(2). pii: 121490. doi: 10.1172/jci.insight.121490. [Epub ahead of print] Abstract Liver cancer is the fourth leading cause of cancer-related mortality and(...)

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Caring for Patients With Multiple Chronic Conditions

Caring for Patients With Multiple Chronic Conditions

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ARTICLE: Caring for Patients With Multiple Chronic Conditions AUTHORS: Mary E. Tinetti, Ariel R. Green, Jennifer Ouellet, Michael W. Rich, Cynthia Boyd JOURNAL: Ann Intern Med. 2019 Jan 22. doi: 10.7326/M18-3269. [Epub ahead of print] Multimorbidity, the coexistence of multiple chronic conditions, is common among all adults receiving health care and the norm among older adults.(...)

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Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

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ARTICLE: Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability AUTHORS: Lindsay F. Rizzardi, Peter F. Hickey, Varenka Rodriguez DiBlasi, Rakel Tryggvadóttir, Colin M. Callahan, Adrian Idrizi, Kasper D. Hansen & Andrew P. Feinberg  JOURNAL: Nat Neurosci. 2019 Feb;22(2):307-316. doi: 10.1038/s41593-018-0297-8. Epub 2019 Jan 14. Abstract Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain(...)

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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

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ARTICLE: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress AUTHORS: Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee & David A. Kass JOURNAL: Nature. 2019 Jan 30. doi: 10.1038/s41586-019-0895-y. [Epub ahead of print] Brief Summary Protein kinase G has long been considered to provide protection against(...)

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