Article of the Week

Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

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ARTICLE: Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes AUTHORS: Peter M. Abadir, Alka Jain, Laura J. Powell, Qian-Li Xue, Jing Tian, Robert G. Hamilton, David A. Bennett, Thomas Finucane, Jeremy D. Walston, Neal S. Fedarko JOURNAL: Circulation. 2017 Jan 31;135(5):449-459. doi: 10.1161/CIRCULATIONAHA.116.022385. Epub 2016 Nov 30. Abstract BACKGROUND: Agonistic angiotensin II type 1 receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or(...)

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Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

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ARTICLE: Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy AUTHORS: Thomas P. Mast, Cynthia A. James, Hugh Calkins, Arco J. Teske, Crystal Tichnell, Brittney Murray, Peter Loh, Stuart D. Russell, Birgitta K. Velthuis, Daniel P. Judge, Dennis Dooijes, Ryan J. Tedford, Jeroen F. van der Heijden, Harikrishna Tandri, Richard N. Hauer, Theodore P. Abraham, Pieter A. Doevendans, Anneline S. J. M. te Riele, Maarten J. Cramer JOURNAL: JAMA Cardiol. 2017 Jan 11. doi: 10.1001/jamacardio.2016.5034. [Epub ahead of print] Abstract IMPORTANCE: Considerable research has described the arrhythmic course of arrhythmogenic right ventricular dysplasia/cardiomyopathy(...)

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Oxidized CaMKII promotes asthma through the activation of mast cells

Oxidized CaMKII promotes asthma through the activation of mast cells

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ARTICLE: Oxidized CaMKII promotes asthma through the activation of mast cells AUTHORS: Jingjing Qu, Danh C. Do, Yufeng Zhou, Elizabeth Luczak, Wayne Mitzner, Mark E. Anderson and Peisong Gao JOURNAL: JCI Insight. 2017 Jan 12;2(1):e90139. doi: 10.1172/jci.insight.90139. Abstract Oxidation of calmodulin-dependent protein kinase II (ox-CaMKII) by ROS has been associated with asthma. However, the contribution of ox-CaMKII to(...)

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Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis

Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis

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ARTICLE: Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis. AUTHORS: Emily A Kendall, Anthony T Fojo, David W Dowdy JOURNAL: Lancet Respir Med. 2016 Dec 16. pii: S2213-2600(16)30423-4. doi: 10.1016/S2213-2600(16)30423-4. [Epub ahead of print] Abstract BACKGROUND: In May, 2016, WHO endorsed a 9 month regimen for multidrug-resistant tuberculosis that is cheaper(...)

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Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients

Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients

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ARTICLE: Dementia and Alzheimer's Disease among Older Kidney Transplant Recipients AUTHORS: Mara A. McAdams-DeMarco, Sunjae Bae, Nadia Chu, Alden L. Gross, Charles H. Brown IV, Esther Oh, Paul Rosenberg, Karin J. Neufeld, Ravi Varadhan, Marilyn Albert, Jeremy Walston and Dorry L. Segev JOURNAL: J Am Soc Nephrol. 2016 Dec 15. pii: ASN.2016080816. [Epub ahead of print] Abstract Older patients with ESRD who receive a kidney transplant (KT) may develop(...)

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Stop Randomizing All Cardiac Arrests

Stop Randomizing All Cardiac Arrests

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ARTICLE: Stop Randomizing All Cardiac Arrests AUTHORS: Myron L. Weisfeldt JOURNAL: Circulation. 2016 Dec 20;134(25):2035-2036. The field of resuscitation science is characterized nearly uniformly by failed clinical trials: be it sodium bicarbonate, epinephrine at low or high dose, vasopressin, continuous or interrupted chest compressions, temperature management, antiarrhythmic drug use, or devices to augment perfusion, none has(...)

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Navigating Ethical Tensions in High-Value Care Education

Navigating Ethical Tensions in High-Value Care Education

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ARTICLE: Navigating Ethical Tensions in High-Value Care Education AUTHORS: Matthew DeCamp and Kevin R. Riggs JOURNAL: JAMA. 2016 Dec 6;316(21):2189-2190. doi: 10.1001/jama.2016.17488. Enthusiasm for high-value care is increasing throughout health care, including in the education of medical students, residents, and fellows.1 Until recently, there were few examples of educational programs that equipped future physicians with the tools required to practice high-value(...)

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Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy

Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy

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ARTICLE: Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy AUTHORS: John W. McEvoy, Seth S. Martin, Zeina A. Dardari, Michael D. Miedema, Veit Sandfort, Joseph Yeboah, Matthew J. Budoff, David C. Goff,Bruce M. Psaty, Wendy S. Post, Khurram Nasir, Roger S. Blumenthal, Michael J. Blaha JOURNAL: Circulation. 2016 Nov 23. pii: CIRCULATIONAHA.116.025471. [Epub ahead of print] Abstract BACKGROUND: There is interest in using atherosclerotic cardiovascular disease (ASCVD) risk to personalize systolic blood pressure (SBP)(...)

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Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

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ARTICLE: Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes AUTHORS: Peter Abadir, Alka Jain, Laura Powell, Qian-Li Xue, Jing Tian, Robert G. Hamilton, David Bennett, Thomas Finucane, Jeremy D. Walston, Neal S. Fedarko JOURNAL: Circulation. 2016 Nov 30. pii: CIRCULATIONAHA.116.022385. [Epub ahead of print] Abstract BACKGROUND: -Agonistic angiotensin II type I receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or risk for adverse health outcomes. AT1RaAbs(...)

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TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

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T cells are an important arm of the immune system that controls infections and tumor growth. When T cells fail, viruses and tumors persist and we see chronic infection or malignancies ensue. There is often high-level expression of a molecule that inhibits T cell function, programmed death-1 or PD-1 on tumor or chronic virus (HIV,(...)

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