Article of the Week

Global Elimination of Chronic Hepatitis

Global Elimination of Chronic Hepatitis

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ARTICLE: Global Elimination of Chronic Hepatitis AUTHOR: David L. Thomas JOURNAL: N Engl J Med. 2019 May 23;380(21):2041-2050. doi: 10.1056/NEJMra1810477. Major advances have been made in the prevention and treatment of chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. Nonetheless, by causing cirrhosis, hepatocellular cancer, or both, HCV and HBV infections kill more than(...)

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Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis

Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis

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ARTICLE: Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis AUTHORS: Dennis G. Moledina, F. Perry Wilson, Jordan S. Pober, Mark A. Perazella, Nikhil Singh, Randy L. Luciano, Wassim Obeid, Haiqun Lin, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, Lloyd G. Cantley, and Chirag R. Parikh JOURNAL: JCI Insight. 2019 May 16;4(10). pii: 127456. doi: 10.1172/jci.insight.127456. eCollection 2019 May 16. Abstract BACKGROUND: Clinical diagnosis of acute interstitial nephritis (AIN) is challenging because of lack of(...)

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Venezuela’s public health crisis: a regional emergency

Venezuela’s public health crisis: a regional emergency

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ARTICLE: Venezuela's public health crisis: a regional emergency AUTHORS: Kathleen R Page, Shannon Doocy, Feliciano Reyna, Ganteaume B Arch, Julio S Castro, Paul Spiegel, Chris Beyrer JOURNAL: Lancet. 2019 Mar 23;393(10177):1254-1260. doi: 10.1016/S0140-6736(19)30344-7. Epub 2019 Mar 11. Abstract The economic crisis in Venezuela has eroded the country's health-care infrastructure and threatened the public health of its(...)

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Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock

Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock

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ARTICLE: Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock AUTHORS: Abdulla Damluji, KarenBandeen-Roche, Carol Berkower, Cynthia Boyd, Mohammed S. Al-Damluji, Mauricio G.Cohen, Daniel E.Forman, Rahul Chaudhary, Gary Gerstenblith, Jeremy Walston, Jon Resar, Mauro Moscucci JOURNAL: J Am Coll Cardiol. 2019 Apr 23;73(15):1890-1900. doi: 10.1016/j.jacc.2019.01.055. Abstract BACKGROUND: Older adults ≥75 years of age carry an increased risk of mortality after ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock.(...)

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

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ARTICLE: The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight AUTHORS: Francine E. Garrett-Bakelman, Manjula Darshi, Stefan J. Green, Ruben C. Gur, Ling Lin, Brandon R. Macias, Miles J. McKenna, Cem Meydan, Tejaswini Mishra, Jad Nasrini, Brian D. Piening, Lindsay F. Rizzardi, Kumar Sharma, Jamila H. Siamwala, Lynn Taylor, Martha Hotz Vitaterna,(...)

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Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study

Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study

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ARTICLE: Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study AUTHORS: Hernández-Ramírez, R.U.Qin, L., Lin, H., Leyden, W., Neugebauer, R.S., Althoff, K.N., Achenbach, C.J., Hessol, N.A., D'Souza, G., Gebo, K.A., Gill, M.J., Grover, S., Horberg, M.A., Li, J., Mathews, W.C., Mayor, A.M., Park, L.S., Rabkin, C.S., Salters, K., Justice, A.C., Moore, R.D., Engels, E.A., Silverberg, M.J., Dubrow, R., Betts,(...)

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Time to Study Metastatic-Cancer Survivorship

Time to Study Metastatic-Cancer Survivorship

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ARTICLE: Time to Study Metastatic-Cancer Survivorship AUTHORS: Terry Langbaum and Thomas J. Smith JOURNAL: N Engl J Med. 2019 Apr 4;380(14):1300-1302. doi: 10.1056/NEJMp1901103. One of us, Terry, has survived four separate cancer diagnoses over the past 37 years and is now living with a treatment-refractory radiation-induced sarcoma; the other, Tom, is living with a recurrence of(...)

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Assessment of Inpatient Time Allocation Among First-Year Internal Medicine Residents Using Time-Motion Observations

Assessment of Inpatient Time Allocation Among First-Year Internal Medicine Residents Using Time-Motion Observations

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The iCOMPARE trial, for which Sanjay Desai is a lead investigator, examined outcomes from trainees with different duty hour standards. The trial was funded by the National Heart Lung Blood Institute and the ACGME, and their primary outcomes were published in a series of manuscripts in the New England Journal of Medicine. Last week, the team(...)

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A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography

A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography

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ARTICLE: A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography AUTHORS: Elizabeth C Oelsner, Victor E Ortega, Benjamin M. Smith, Jennifer N. Nguyen, Ani W Manichaikul, Eric A. Hoffman, Xiuqing Guo, Kent D Taylor, Prescott G Woodruff, David J Couper, Nadia N Hansel, Fernando J. Martinez, Robert Paine III, MeiLan K Han, Christopher Cooper, Mark T Dransfield, Gerard Criner, Jerry A Krishnan, Russell Bowler, Eugene R Bleecker, Stephen Peters, Stephen S.(...)

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Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project

Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project

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ARTICLE: Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project AUTHORS: Seamus P. Whelton, Paul McAuley, Olusola Orimoloye, Erin Michos, Clinton Brawner, Jonathan Ehrman, Steven Keteyian, Mouaz Al-Mallah and Michael Blaha JOURNAL: J Am Coll Cardiol. 2019 Mar 26;73(9). doi: 10.1016/S0735-1097(19)33770-2. Abstract Background: Traditional cardiovascular disease (CVD) risk factors have a decreased predictive(...)

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