Medicine Matters

ARTICLE: A Pragmatic, Randomized Controlled Trial of Oral Antivirals for the Treatment of Chronic Hepatitis C: The PRIORITIZE Study AUTHORS: Mark S Sulkowski, Juhi S Moon, Kenneth E Sherman, Giuseppe Morelli, Jama M Darling, Andrew J Muir, Mandana Khalili, Dawn A Fishbein, Federico Hinestrosa, Mitchell L Shiffman, Adrian Di Bisceglie, K Rajender Reddy, Brian Pearlman, Anna S Lok, Michael W Fried, Paul W Stewart, Joy Peter, Summer Wadsworth, Scott Kixmiller, Anquenette Sloan, Monika Vainorius, Patrick M […]

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ARTICLE: Host lipidome and tuberculosis treatment failure AUTHORS: Rupak Shivakoti, John W Newman, Luke Elizabeth Hanna, Artur T L Queiroz , Kamil Borkowski, Akshay N Gupte, Mandar Paradkar, Pattabiraman Satyamurthi, Vandana Kulkarni, Murugesh Selva, Neeta Pradhan, Shri Vijay Bala Yogendra Shivakumar, Saravanan Natarajan, Ramesh Karunaianantham, Nikhil Gupte, Kannan Thiruvengadam, Oliver Fiehn, Renu Bharadwaj, Anju Kagal, Sanjay Gaikwad, Shashikala Sangle, Jonathan E Golub, Bruno B Andrade, Vidya Mave, Amita Gupta, Chandrasekaran Padmapriyadarsini JOURNAL: Eur Respir J. 2022 Jan 6;59(1):2004532. doi: 10.1183/13993003.04532-2020. Print 2022 Jan. […]

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ARTICLE: HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression AUTHORS: Liping Li, Jung-Hyun Kim, Wenyan Lu, Donna M Williams, Joseph Kim, Leslie Cope, Raajit K Rampal, Richard P Koche, Lingling Xian, Li Z Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C Stubbs, Karen Reddy, Antonio-Rodriguez Romero, Bethan Psaila, Jerry L Spivak, Alison R Moliterno, Linda M S Resar JOURNAL: Blood. 2022 May 5;139(18):2797-2815. doi: 10.1182/blood.2021013925. Abstract […]

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ARTICLE: Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study AUTHORS: Akshay N Gupte, Pavan Kumar, Mariana Araújo-Pereira, Vandana Kulkarni, Mandar Paradkar, Neeta Pradhan, Pradeep Menon, Chandrasekaran Padmapriyadarsini, Luke-Elizabeth Hanna, Shri Vijay Bala Yogendra Shivakumar, Neesha Rockwood, Elsa Du Bruyn, Rajesh Karyakarte, Sanjay Gaikwad, Robert Bollinger, Jonathan Golub, Nikhil Gupte, Vijay Viswanathan, Robert J Wilkinson, Vidya Mave, Subash Babu, Hardy Kornfeld, Bruno B Andrade, Amita Gupta JOURNAL: Eur Respir J. 2022 Apr […]

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ARTICLE: Estimation of the Global Gap in Clinic Visits for Hypertension Care Between Patient Need and Physician Capacity AUTHORS: Dinesh Neupane, Yumin Gao, Yijing Feng, Kunihiro Matsushita, Lawrence J Appel JOURNAL: Hypertension. 2021 Sep;78(3):779-786. doi: 10.1161/HYPERTENSIONAHA.121.17660. Epub 2021 Aug 11. Abstract In most countries, only physicians are allowed to prescribe antihypertensive medication. Thus, physician capacity (number of physician clinic […]

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ARTICLE: Plasma virome and the risk of blood-borne infection in persons with substance use disorder AUTHORS: Abraham J Kandathil, Andrea L Cox, Kimberly Page, David Mohr, Roham Razaghi, Khalil G Ghanem, Susan A Tuddenham, Yu-Hsiang Hsieh, Jennifer L Evans, Kelly E Coller, Winston Timp, David D Celentano, Stuart C Ray, David L Thomas JOURNAL: Nat Commun. 2021 Nov 25;12(1):6909. doi: […]

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ARTICLE: Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy AUTHORS: Amit Kaushik, Nicole C Ammerman, Rokeya Tasneen, Sophie Lachau-Durand, Koen Andries, Eric Nuermberger JOURNAL: Am J Respir Crit Care Med. 2022 Mar 1;205(5):570-579. doi: 10.1164/rccm.202012-4541OC. Abstract Rationale: Completion of preventive therapy is a major bottleneck in global tuberculosis control. Long-acting injectable drug formulations would shorten therapy administration […]

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ARTICLE: Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis AUTHORS: Jeffrey A Tornheim, Zarir F Udwadia, Prerna R Arora, Ishita Gajjar, Nikhil Gupte, Samridhi Sharma, Megha Karane, Namrata Sawant, Nisha Kharat, Alexander J Blum, Shri Vijay Bala Yogendra Shivakumar, Jai B Mullerpattan, Lancelot M Pinto, Tester F Ashavaid, Amita […]

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ARTICLE: A minimal monitoring approach for the treatment of hepatitis C virus infection (ACTG A5360 [MINMON]): a phase 4, open-label, single-arm trial AUTHORS: Sunil S Solomon, Sandra Wagner-Cardoso, Laura Smeaton, Leonard A Sowah, Chanelle Wimbish, Gregory Robbins, Irena Brates, Christine Scello, Annie Son, Anchalee Avihingsanon, Benjamin Linas, Donald Anthony, Estevão Portela Nunes, Dimas A Kliemann, Khuanchai Supparatpinyo, Cissy Kityo, Pablo Tebas, Jaclyn Ann Bennet, Jorge Santana-Bagur, Constance A Benson, Marije Van Schalkwyk, Nelson Cheinquer, Susanna Naggie, David Wyles, Mark […]

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