ARTICLE: Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV AUTHORS: Robert C Bollinger, Chloe L Thio, Mark S Sulkowski, Jane McKenzie-White, David L Thomas and Charles Flexner JOURNAL: Lancet HIV. 2019 Dec 20. pii: S2352-3018(19)30342-X. doi: 10.1016/S2352-3018(19)30342-X. [Epub ahead of print] Abstract The first long-acting formulations of HIV drugs are undergoing regulatory review for use […]
Article of the Week
Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association
Posted by | Article of the WeekARTICLE: Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association AUTHORS: Abdulla A. Damluji, Daniel E. Forman, Sean van Diepen, Karen P. Alexander, Robert L. Page II, Scott L. Hummel, Venu Menon, Jason N. Katz, Nancy M. Albert, Jonathan Afilalo, Mauricio G. Cohen JOURNAL: Circulation. 2019 Dec 9:CIR0000000000000741. doi: 10.1161/CIR.0000000000000741. [Epub ahead of print] Abstract Longevity is increasing, and more adults are living to […]
Association Between Treatment by Fraud and Abuse Perpetrators and Health Outcomes Among Medicare Beneficiaries
Posted by | Article of the WeekARTICLE: Association Between Treatment by Fraud and Abuse Perpetrators and Health Outcomes Among Medicare Beneficiaries AUTHORS: Lauren Hersch Nicholas, Caroline Hanson, Jodi B. Segal, Matthew D. Eisenberg JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4771. [Epub ahead of print] Abstract IMPORTANCE: Fraud and abuse contribute to unnecessary spending in the Medicare program, and federal agencies have prioritized fund recovery and the exclusion of health care […]
Association of Long-term Ambient Ozone Exposure with Respiratory Morbidity in Smokers
Posted by | Article of the WeekARTICLE: Association of Long-term Ambient Ozone Exposure with Respiratory Morbidity in Smokers AUTHORS: Laura M. Paulin, Amanda J. Gassett, Neil E. Alexis, Kipruto Kirwa, Richard E. Kanner, Stephen Peters, Jerry A. Krishnan, Robert Paine III, Mark Dransfield, Prescott G. Woodruff, Christopher B. Cooper, R. Graham Barr, Alejandro P. Comellas, Cheryl S. Pirozzi, MeiLan Han, Eric A. Hoffman, Fernando J. Martinez, Han Woo, Roger D. Peng, Ashraf Fawzy, Nirupama Putcha, Patrick N. Breysse, Joel D. Kaufman, Nadia N. Hansel, for SPIROMICS investigators JOURNAL: JAMA Intern Med. 2019 Dec 9. […]
Time From Submission of Johns Hopkins University Trial Results to Posting on ClinicalTrials.gov
Posted by | Article of the WeekARTICLE: Time From Submission of Johns Hopkins University Trial Results to Posting on ClinicalTrials.gov AUTHORS: Anthony Keyes, Evan Mayo-Wilson, Nidhi Atri, Aliya Lalji, Prince S. Nuamah, Oswald Tetteh and Daniel E. Ford JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4710. [Epub ahead of print] The US Food and Drug Administration Amendments Act of 2007 (FDAAA)1 requires that applicable clinical trials (ACTs) […]
Confronting Bias and Discrimination in Health Care–When Silence Is Not Golden
Posted by | Article of the WeekARTICLE: Confronting Bias and Discrimination in Health Care-When Silence Is Not Golden AUTHORS: Lisa Cooper, Mary Catherine Beach and David Williams JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4100. [Epub ahead of print] In this issue of JAMA Internal Medicine, Wheeler et al1 report results from a novel qualitative study in which the investigators examined how physicians and trainees perceive, react, and respond to incidents of […]
Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity
Posted by | Article of the WeekARTICLE: Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity AUTHORS: Ling Li, Hildur Knutsdottir, Ken Hui, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Joel S. Bader and Florin M. Selaru JOURNAL: JCI Insight. 2019 Jan 24;4(2). […]
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Posted by | Article of the WeekARTICLE: A quantitative approach for measuring the reservoir of latent HIV-1 proviruses AUTHORS: Katherine M. Bruner, Zheng Wang, Francesco R. Simonetti, Alexandra M. Bender, Kyungyoon J. Kwon, Srona Sengupta, Emily J. Fray, Subul A. Beg, Annukka A. R. Antar, Katharine M. Jenike, Lynn N. Bertagnolli, Adam A. Capoferri, Joshua T. Kufera, Andrew Timmons, Christopher Nobles, John Gregg, Nikolas Wada, Ya-Chi Ho, Hao Zhang, Joseph B. Margolick, Joel N. Blankson, Steven G. Deeks, Frederic D. Bushman, Janet D. Siliciano, Gregory […]
Effect of a Hospital-Initiated Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Patients Hospitalized with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial
Posted by | Article of the WeekARTICLE: Effect of a Hospital-Initiated Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Patients Hospitalized with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial AUTHORS: Hanan Aboumatar, Mohammad Naqibuddin, Suna Chung, Hina Chaudhry, Samuel W. Kim, Jamia Saunders, Lee Bone, Ayse P. Gurses, Amy Knowlton, Peter Pronovost, Nirupama Putcha, Cynthia Rand, Debra Roter, Carol Sylvester, Carol Thompson, Jennifer L. Wolff, Judith Hibbard, Robert Wise […]
Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease
Posted by | Article of the WeekARTICLE: Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease AUTHORS: Erin D. Michos, John W. McEvoy, and Roger S. Blumenthal JOURNAL: N Engl J Med. 2019 Oct 17; 381:1557-1567 In 1961, the investigators involved in the Framingham Heart Study identified serum cholesterol as one of the “factors of risk” for coronary heart disease.1 Since then, […]