ARTICLE: MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury AUTHORS: Christian U Oeing, Seungho Jun, Sumita Mishra, Brittany Dunkerly-Eyring, Anna Chen, Maria I Grajeda, Usman Tahir, Robert E Gerszten, Nazareno Paolocci, Mark J Ranek, David A Kass JOURNAL: Circ Res. 2021 Jan 6. doi: 10.1161/CIRCRESAHA.120.317710. Online ahead of print. Abstract Rationale: The mechanistic target of rapamycin complex-1 (mTORC1) controls metabolism and protein homeostasis, and is […]
Article of the Week
Myocardial Injury in Severe COVID-19 Compared to Non-COVID Acute Respiratory Distress Syndrome
Posted by | Article of the WeekARTICLE: Myocardial Injury in Severe COVID-19 Compared to Non-COVID Acute Respiratory Distress Syndrome AUTHORS: Thomas S Metkus, Lori J Sokoll, Andreas S Barth, Matthew J Czarny, Allison G Hays, Charles J Lowenstein, Erin D Michos, Eric P Nolley, Wendy S Post, Jon R Resar, David R Thiemann, Jeffrey C Trost, Rani K Hasan JOURNAL: Circulation. 2020 Nov 13. doi: 10.1161/CIRCULATIONAHA.120.050543. Online ahead of print. Abstract Background: Knowledge gaps remain […]
Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene
Posted by | Article of the WeekARTICLE: Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene AUTHORS: Nirupama Putcha, Ashraf Fawzy, Elizabeth C Matsui, Mark C Liu, Russ P Bowler, Prescott G Woodruff, Wanda K O'Neal, Alejandro P Comellas, MeiLan K Han, Mark T Dransfield, J Michael Wells, Njira Lugogo, Li Gao, C Conover Talbot Jr, Eric A Hoffman, Christopher B Cooper, Laura M Paulin, Richard E Kanner, Gerard Criner, Victor E Ortega, R Graham Barr, Jerry […]
COVID-19 and myeloid cells: complex interplay correlates with lung severity
Posted by | Article of the WeekARTICLE: COVID-19 and myeloid cells: complex interplay correlates with lung severity AUTHORS: Franco R. D’Alessio and Nicola M. Heller JOURNAL: J Clin Invest. 2020 Dec 1;130(12):6214-6217. doi: 10.1172/JCI143361. Abstract COVID-19 spans a wide range of symptoms, sometimes with profound immune system involvement. How immune cell subsets change during the disease course and with disease severity needs further study. […]
Nonpharmacological Interventions for Managing Breathlessness in Patients With Advanced Cancer: A Systematic Review
Posted by | Article of the WeekARTICLE: Nonpharmacological Interventions for Managing Breathlessness in Patients With Advanced Cancer: A Systematic Review AUTHORS: Arjun Gupta, Ramy Sedhom, Ritu Sharma, Allen Zhang, Julie M Waldfogel, Josephine L Feliciano, Jeff Day, Rebecca A Gersten, Patricia M Davidson, Eric B Bass, Sydney M Dy JOURNAL: JAMA Oncol. 2020 Nov 19. doi: 10.1001/jamaoncol.2020.5184. Online ahead of print. Abstract Importance: Breathlessness is a frequent and debilitating symptom in patients with […]
Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports
Posted by | Article of the WeekARTICLE: Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports AUTHORS: Douglas E. Gladstone, Bo Soo Kim, Kathy Mooney, Andrew H. Karaba, Franco R. D'Alessio JOURNAL: Ann Intern Med. 2020 Nov 17;173(10):852-853. doi: 10.7326/L20-0681. Epub 2020 Jul 6. Abstract Background: Normally, regulatory T cells (also known as T regulatory cells or Tregs) migrate into inflamed tissues, […]
The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults: A Response-Adaptive, Randomized Clinical Trial
Posted by | Article of the WeekARTICLE: The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults: A Response-Adaptive, Randomized Clinical Trial AUTHORS: Lawrence J Appel, Erin D Michos, Christine M Mitchell, Amanda L Blackford, Alice L Sternberg, Edgar R Miller III, Stephen P Juraschek, Jennifer A Schrack, Sarah L Szanton, Jeanne Charleston, Melissa Minotti, Sheriza N Baksh, Robert H Christenson, Josef Coresh, Lea T Drye, Jack M Guralnik, Rita R Kalyani, Timothy B […]
Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study
Posted by | Article of the WeekARTICLE: Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study AUTHORS: Christine M Durand, Adam A Capoferri, Andrew D Redd, Marianna Zahurak, Daniel I S Rosenbloom, Ayla Cash, Robin K Avery, Javier Bolaños-Meade, Catherine M Bollard, C Korin Bullen, Charles Flexner, Ephraim J Fuchs, Joel Gallant, Doug E Gladstone, Christopher D Gocke, Richard J Jones, Yvette L Kasamon, Jun Lai, Mark Levis, Leo Luznik, Kieren A […]
Cardiopulmonary Hemodynamics in Pulmonary Hypertension and Heart Failure: JACC Review Topic of the Week
Posted by | Article of the WeekARTICLE: Cardiopulmonary Hemodynamics in Pulmonary Hypertension and Heart Failure: JACC Review Topic of the Week AUTHORS: Bradley A Maron, Gabor Kovacs, Anjali Vaidya, Deepak L Bhatt, Rick A Nishimura, Susanna Mak, Marco Guazzi, Ryan J Tedford JOURNAL: J Am Coll Cardiol. 2020 Dec 1;76(22):2671-2681. doi: 10.1016/j.jacc.2020.10.007. Abstract Pulmonary hypertension (PH) is an independent risk factor for adverse clinical outcome, particularly in left heart disease […]
Mitigating Health-Care Worker Distress From Scarce Medical Resource Allocation During a Public Health Crisis
Posted by | Article of the WeekARTICLE: Mitigating Health-Care Worker Distress From Scarce Medical Resource Allocation During a Public Health Crisis AUTHORS: Lauren E Benishek, Allen Kachalia, Lee Daugherty Biddison, Albert W Wu JOURNAL: Chest. 2020 Aug 6;158(6):2285-2287. doi: 10.1016/j.chest.2020.07.073. Online ahead of print. The coronavirus disease 2019 (COVID-19) pandemic has exposed a significant vulnerability of the US health-care system: the limited supply of life-saving medical resources, […]