Article of the Week

Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

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ARTICLE: Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation Insights From the FOURIER Trial AUTHORS: Seth S. Martin, Robert P. Giugliano, Sabina A. Murphy, Scott M. Wasserman, Evan A. Stein, Richard Češka, José López-Miranda, Borislav Georgiev, Alberto J. Lorenzatti, Matti J. Tikkanen, Peter S. Sever, Anthony C. Keech, Terje R. Pedersen, Marc S. Sabatine JOURNAL: JAMA Cardiol. 2018 Jun 13. doi: 10.1001/jamacardio.2018.1533. [Epub ahead of print] Abstract IMPORTANCE: Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which(...)

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Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA

Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA

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ARTICLE: Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA AUTHORS: Peiqi Wang, Tim Xu, Saowanee Ngamruengphong, Martin Makary, Anthony Kalloo, Susan Hutfless JOURNAL: Gut. 2018 May 18. pii: gutjnl-2017-315308. doi: 10.1136/gutjnl-2017-315308. [Epub ahead of print] Abstract OBJECTIVE: Over 15 million colonoscopies and 7 million osophagogastroduodenoscopies (OGDs) are performed annually in the USA. We aimed to estimate the(...)

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Improving the Supply and Quality of Deceased-Donor Organs for Transplantation

Improving the Supply and Quality of Deceased-Donor Organs for Transplantation

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ARTICLE: Improving the Supply and Quality of Deceased-Donor Organs for Transplantation AUTHORS: Stefan G. Tullius and Hamid Rabb JOURNAL: N Engl J Med. 2018 May 17;378(20):1920-1929. doi: 10.1056/NEJMra1507080. Introduction Organ transplantation is the treatment of choice for many patients with end-stage diseases, but the supply of organs that are considered acceptable according to current criteria is(...)

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Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data

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ARTICLE: Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data AUTHORS: Dalin Rifat, Brendan Prideaux, Radojka M. Savic, Michael E. Urbanowski, Teresa L. Parsons, Brian Luna, Mark A. Marzinke, Alvaro A. Ordonez, Vincent P. DeMarco, Sanjay K. Jain, Veronique Dartois, William R. Bishai and Kelly E. Dooley JOURNAL: Sci Transl Med. 2018 Apr 4;10(435). pii: eaai7786. doi: 10.1126/scitranslmed.aai7786. Abstract In clinical trials of two rifamycin antibiotics(...)

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Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests

Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests

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ARTICLE: Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests AUTHORS: Ross A. Pollack, Siobhan P. Brown, Thomas Rea, Tom Aufderheide, David Barbic, Jason E. Buick, Jim Christenson, Ahamed H. Idris, Jamie Jasti, Michael Kampp, Peter Kudenchuk, Susanne May, Marc Muhr, Graham Nichol, Joseph P. Ornato, George Sopko, Christian Vaillancourt, Laurie Morrison, Myron Weisfeldt JOURNAL: Circulation. 2018 May 15;137(20):2104-2113. doi: 10.1161/CIRCULATIONAHA.117.030700. Epub 2018 Feb 26.(...)

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Methods for Evaluating Natural Experiments in Obesity: A Systematic Review

Methods for Evaluating Natural Experiments in Obesity: A Systematic Review

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ARTICLE: Methods for Evaluating Natural Experiments in Obesity: A Systematic Review AUTHORS: Wendy L. Bennett, Renee F. Wilson, Allen Zhang, Eva Tseng, Emily A. Knapp, Hadi Kharrazi, Elizabeth A. Stuart, Oluwaseun Shogbesan, Eric B. Bass, Lawrence J. Cheskin JOURNAL: Ann Intern Med. 2018 May 1:1-10. doi: 10.7326/M18-0309. [Epub ahead of print] Abstract BACKGROUND: Given the obesity pandemic, rigorous methodological approaches, including natural experiments,(...)

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Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

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ARTICLE: Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure AUTHORS: Peter P. Rainer, Peihong Dong, Matteo Sorge, Justyna Fert-Bober, Ronald J. Holewinski, Yuchuan Wang, Catherine A. Foss, Steven S. An, Alessandra Baracca, Giancarlo Solaini, Charles G. Glabe, Martin G. Pomper, Jennifer E. Van Eyk, Gordon F. Tomaselli, Nazareno Paolocci, Giulio Agnetti JOURNAL: Circ Res. 2018 May 11;122(10):e75-e83. doi: 10.1161/CIRCRESAHA.117.312082. Epub 2018 Feb 26. Abstract RATIONALE: Disrupted(...)

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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ARTICLE: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 AUTHORS: Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.(...)

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How to Incorporate Quality Improvement and Patient Safety Projects in Your Training

How to Incorporate Quality Improvement and Patient Safety Projects in Your Training

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ARTICLE: How to Incorporate Quality Improvement and Patient Safety Projects in Your Training AUTHORS: Shazia Mehmood Siddique, Gyanprakash Ketwaroo, Carolyn Newberry, Simon Mathews, Vandana Khungar, Shivan J. Mehta JOURNAL: Gastroenterology. 2018 May;154(6):1564-1568. doi: 10.1053/j.gastro.2018.03.044. Epub 2018 Mar 28. Abstract Engaging physicians in quality improvement (QI) and patient safety (PS) efforts has become increasingly central to creating(...)

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The Key Role of Epigenetics in Human Disease Prevention and Mitigation

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

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ARTICLE: The Key Role of Epigenetics in Human Disease Prevention and Mitigation AUTHOR: Andrew P. Feinberg JOURNAL: N Engl J Med. 2018 Apr 5;378(14):1323-1334. doi: 10.1056/NEJMra1402513. The epigenome consists of nuclear information, heritable during cell division, that controls development, tissue differentiation, and cellular responsiveness. Epigenetic information is controlled by genome sequence, environmental exposure, and stochasticity, or random chance. As(...)

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