Article of the Week

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

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ARTICLE: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis AUTHORS: Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale,(...)

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FDA Regulation of Prescription Drugs

FDA Regulation of Prescription Drugs

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ARTICLE: FDA Regulation of Prescription Drugs AUTHORS: Audrey L. Gassman, Christine P. Nguyen and Hylton V. Joffe JOURNAL: N Engl J Med. 2017 Feb 16;376(7):674-682. doi: 10.1056/NEJMra1602972. In 2015, approximately 4 billion prescriptions were filled at retail pharmacies in the United States.1 The Center for Drug Evaluation and Research (CDER) within the Food and Drug Administration (FDA)(...)

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International Exchange and American Medicine

International Exchange and American Medicine

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ARTICLE: International Exchange and American Medicine AUTHORS: Katrina Armstrong, Mark E. Anderson, John M. Carethers, Joseph Loscalzo, Michael S. Parmacek, Robert M. Wachter and Mark L. Zeidel JOURNAL: N Engl J Med. 2017 Feb 1. doi: 10.1056/NEJMp1701339. [Epub ahead of print] On January 27, 2017, President Donald Trump issued an executive order suspending “entry into the(...)

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A View from the Front Line — Physicians’ Perspectives on ACA Repeal

A View from the Front Line — Physicians’ Perspectives on ACA Repeal

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ARTICLE: A View from the Front Line — Physicians’ Perspectives on ACA Repeal AUTHORS: Craig Evan Pollack, Katrina Armstrong and David Grande JOURNAL: N Engl J Med. 2017 Feb 9;376(6):e8. doi: 10.1056/NEJMp1700144. Epub 2017 Jan 25. The recent election of Donald Trump as President of the United States has created substantial uncertainty about the future of(...)

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Wearable Technology and Long-term Weight Loss

Wearable Technology and Long-term Weight Loss

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ARTICLE: Wearable Technology and Long-term Weight Loss AUTHORS: Timothy Plante and Seth Martin JOURNAL: JAMA. 2017 Jan 17;317(3):318-319. doi: 10.1001/jama.2016.19265. To the Editor After successful weight loss with weekly group sessions over the initial 6 months of the IDEA trial, individuals randomized to an enhanced intervention group using a physical activity tracking device regained more weight over(...)

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Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

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ARTICLE: Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes AUTHORS: Peter M. Abadir, Alka Jain, Laura J. Powell, Qian-Li Xue, Jing Tian, Robert G. Hamilton, David A. Bennett, Thomas Finucane, Jeremy D. Walston, Neal S. Fedarko JOURNAL: Circulation. 2017 Jan 31;135(5):449-459. doi: 10.1161/CIRCULATIONAHA.116.022385. Epub 2016 Nov 30. Abstract BACKGROUND: Agonistic angiotensin II type 1 receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or(...)

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Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

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ARTICLE: Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy AUTHORS: Thomas P. Mast, Cynthia A. James, Hugh Calkins, Arco J. Teske, Crystal Tichnell, Brittney Murray, Peter Loh, Stuart D. Russell, Birgitta K. Velthuis, Daniel P. Judge, Dennis Dooijes, Ryan J. Tedford, Jeroen F. van der Heijden, Harikrishna Tandri, Richard N. Hauer, Theodore P. Abraham, Pieter A. Doevendans, Anneline S. J. M. te Riele, Maarten J. Cramer JOURNAL: JAMA Cardiol. 2017 Jan 11. doi: 10.1001/jamacardio.2016.5034. [Epub ahead of print] Abstract IMPORTANCE: Considerable research has described the arrhythmic course of arrhythmogenic right ventricular dysplasia/cardiomyopathy(...)

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Oxidized CaMKII promotes asthma through the activation of mast cells

Oxidized CaMKII promotes asthma through the activation of mast cells

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ARTICLE: Oxidized CaMKII promotes asthma through the activation of mast cells AUTHORS: Jingjing Qu, Danh C. Do, Yufeng Zhou, Elizabeth Luczak, Wayne Mitzner, Mark E. Anderson and Peisong Gao JOURNAL: JCI Insight. 2017 Jan 12;2(1):e90139. doi: 10.1172/jci.insight.90139. Abstract Oxidation of calmodulin-dependent protein kinase II (ox-CaMKII) by ROS has been associated with asthma. However, the contribution of ox-CaMKII to(...)

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Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis

Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis

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ARTICLE: Expected effects of adopting a 9 month regimen for multidrug-resistant tuberculosis: a population modelling analysis. AUTHORS: Emily A Kendall, Anthony T Fojo, David W Dowdy JOURNAL: Lancet Respir Med. 2016 Dec 16. pii: S2213-2600(16)30423-4. doi: 10.1016/S2213-2600(16)30423-4. [Epub ahead of print] Abstract BACKGROUND: In May, 2016, WHO endorsed a 9 month regimen for multidrug-resistant tuberculosis that is cheaper(...)

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Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients

Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients

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ARTICLE: Dementia and Alzheimer's Disease among Older Kidney Transplant Recipients AUTHORS: Mara A. McAdams-DeMarco, Sunjae Bae, Nadia Chu, Alden L. Gross, Charles H. Brown IV, Esther Oh, Paul Rosenberg, Karin J. Neufeld, Ravi Varadhan, Marilyn Albert, Jeremy Walston and Dorry L. Segev JOURNAL: J Am Soc Nephrol. 2016 Dec 15. pii: ASN.2016080816. [Epub ahead of print] Abstract Older patients with ESRD who receive a kidney transplant (KT) may develop(...)

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