ARTICLE: Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018 AUTHORS: Alejandra Ellison-Barnes, Sara Johnson, Kimberly Gudzune JOURNAL: JAMA. 2021 Nov 23;326(20):2073-2074. doi: 10.1001/jama.2021.16685. Abstract Methods: We used nationally representative data from the National Health and Nutrition Examination Survey (NHANES), a series of cross-sectional surveys including interviews and physical examinations with a stratified, multistage […]
Article of the Week
Use of Hydroxychloroquine, Remdesivir, and Dexamethasone Among Adults Hospitalized With COVID-19 in the United States
Posted by | Article of the WeekARTICLE: Use of Hydroxychloroquine, Remdesivir, and Dexamethasone Among Adults Hospitalized With COVID-19 in the United States AUTHORS: Hemalkumar B Mehta, Huijun An, Kathleen M Andersen, Omar Mansour, Vithal Madhira, Emaan S Rashidi, Benjamin Bates, Soko Setoguchi, Corey Joseph, Paul T Kocis, Richard Moffitt, Tellen D Bennett, Christopher G Chute, Brian T Garibaldi, G Caleb Alexander, National COVID Cohort Collaborative (N3C) JOURNAL: Ann Intern Med. 2021 Oct;174(10):1395-1403. doi: 10.7326/M21-0857. Epub 2021 […]
Lessons from SGLT-2 inhibitors: rethinking endpoints for heart failure studies
Posted by | Article of the WeekARTICLE: Lessons from SGLT-2 inhibitors: rethinking endpoints for heart failure studies AUTHORS: Sheng Fu, Sheldon E Litwin, Ryan J Tedford JOURNAL: Nat Med. 2021 Nov 11. doi: 10.1038/s41591-021-01565-6. Online ahead of print. SGLT-2 inhibitors show promise for treatment of heart failure with preserved ejection fraction, but clinical data are nuanced. Appropriate endpoint selection will be key to deciphering their benefits. […]
Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels
Posted by | Article of the WeekARTICLE: Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels AUTHORS: Aparna Sajja, Jihwan Park, Vasanth Sathiyakumar, Bibin Varghese, Vincent A Pallazola, Francoise A Marvel, Krishnaji Kulkarni, Alagarraju Muthukumar, Parag H Joshi, Eugenia Gianos, Benjamin Hirsh, Guy Mintz, Anne Goldberg, Pamela B Morris, Garima Sharma, Roger S Blumenthal, Erin D Michos, Wendy S Post, Mohamed B Elshazly, Steven R. Jones, Seth S. Martin JOURNAL: JAMA Netw Open. 2021 Oct 1;4(10):e2128817. doi: 10.1001/jamanetworkopen.2021.28817. […]
Clinical Effectiveness of Integrase Strand Transfer Inhibitor-Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Posted by | Article of the WeekARTICLE: Clinical Effectiveness of Integrase Strand Transfer Inhibitor-Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada AUTHORS: Haidong Lu, Stephen R Cole, Daniel Westreich, Michael G Hudgens, Adaora A Adimora, Keri N Althoff, Michael J Silverberg, Kate Buchacz, Jun Li, Jessie K Edwards, Peter F Rebeiro, Viviane D Lima, Vincent C Marconi, Timothy R Sterlin, Michael A Horberg, M […]
Effects of Different Rest Period Durations Prior to Blood Pressure Measurement: The Best Rest Trial
Posted by | Article of the WeekARTICLE: Effects of Different Rest Period Durations Prior to Blood Pressure Measurement: The Best Rest Trial AUTHORS: Tammy M Brady, Jeanne Charleston, Junichi Ishigami, Edgar R Miller 3rd, Kunihiro Matsushita, Lawrence J Appel JOURNAL: Hypertension. 2021 Nov;78(5):1511-1519. doi: 10.1161/HYPERTENSIONAHA.121.17496. Epub 2021 Oct 4. Abstract A rest period of 3 to 5 minutes before blood pressure (BP) measurement is recommended in hypertension guidelines […]
Addressing the post-acute sequelae of SARS-CoV-2 infection: a multidisciplinary model of care
Posted by | Article of the WeekARTICLE: Addressing the post-acute sequelae of SARS-CoV-2 infection: a multidisciplinary model of care AUTHORS: Ann M Parker, Emily Brigham, Bronwen Connolly, Joanne McPeake, Anna V Agranovich, Michael T Kenes, Kelly Casey, Cynthia Reynolds, Konrad F R Schmidt, Soo Yeon Kim, Adam Kaplin, Carla M Sevin, Martin B Brodsky, Alison E Turnbull JOURNAL: Lancet Respir Med. 2021 Oct 19;9(11):1328-1341. Abstract As of July 31, 2021, SARS-CoV-2 had infected almost 200 […]
PDE1 Inhibition Modulates Ca v 1.2 Channel to Stimulate Cardiomyocyte Contraction
Posted by | Article of the WeekARTICLE: PDE1 Inhibition Modulates Ca v 1.2 Channel to Stimulate Cardiomyocyte Contraction AUTHORS: Grace K Muller, Joy Song, Vivek Jani, Yuejin Wu, Ting Liu, William P D Jeffreys, Brian O'Rourke, Mark E Anderson, David A Kass JOURNAL: Circ Res. 2021 Oct 15;129(9):872-886. doi: 10.1161/CIRCRESAHA.121.319828. Epub 2021 Sep 15. Abstract Rationale: cAMP activation of PKA (protein kinase A) stimulates excitation-contraction (EC) coupling, increasing cardiac contractility. This is clinically achieved […]
Early Uptake of the Acute Hospital Care at Home Waiver
Posted by | Article of the WeekARTICLE: Early Uptake of the Acute Hospital Care at Home Waiver AUTHORS: David M. Levine, Linda V. DeCherrie, Albert L. Siu, Bruce Leff JOURNAL: Ann Intern Med. 2021 Oct 26. doi: 10.7326/M21-2516. Online ahead of print. Abstract Background: Hospital at home (HaH) provides acute hospital-level care in a patient's home as a substitute for traditional inpatient hospital care. The HaH model has […]
Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice
Posted by | Article of the WeekARTICLE: Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice AUTHORS: Sumita Mishra, Nandhini Sadagopan, Brittany Dunkerly-Eyring, Susana Rodriguez, Dylan C Sarver, Ryan P Ceddia, Sean A Murphy, Hildur Knutsdottir, Vivek P Jani, Deepthi Ashok, Christian U Oeing, Brian O'Rourke, Jon A Gangoiti, Dorothy D Sears, G William Wong, Sheila Collins, David Kass JOURNAL: J Clin Invest. 2021 Oct 7;e148798. doi: 10.1172/JCI148798. Online ahead of print. Abstract […]