ARTICLE: Cardiopulmonary Hemodynamics in Pulmonary Hypertension and Heart Failure: JACC Review Topic of the Week AUTHORS: Bradley A Maron, Gabor Kovacs, Anjali Vaidya, Deepak L Bhatt, Rick A Nishimura, Susanna Mak, Marco Guazzi, Ryan J Tedford JOURNAL: J Am Coll Cardiol. 2020 Dec 1;76(22):2671-2681. doi: 10.1016/j.jacc.2020.10.007. Abstract Pulmonary hypertension (PH) is an independent risk factor for adverse clinical outcome, particularly in left heart disease […]
Article of the Week
Mitigating Health-Care Worker Distress From Scarce Medical Resource Allocation During a Public Health Crisis
Posted by | Article of the WeekARTICLE: Mitigating Health-Care Worker Distress From Scarce Medical Resource Allocation During a Public Health Crisis AUTHORS: Lauren E Benishek, Allen Kachalia, Lee Daugherty Biddison, Albert W Wu JOURNAL: Chest. 2020 Aug 6;158(6):2285-2287. doi: 10.1016/j.chest.2020.07.073. Online ahead of print. The coronavirus disease 2019 (COVID-19) pandemic has exposed a significant vulnerability of the US health-care system: the limited supply of life-saving medical resources, […]
Reduced Right Ventricular Sarcomere Contractility in HFpEF with Severe Obesity
Posted by | Article of the WeekARTICLE: Reduced Right Ventricular Sarcomere Contractility in HFpEF with Severe Obesity AUTHORS: M. Imran Aslam, Virginia S. Hahn, Vivek Jani, Steven Hsu, Kavita Sharma, and David A. Kass JOURNAL: Circulation. 2020 Dec 2. doi:10.1161/CIRCULATIONAHA.120.052414 Half of heart failure patients have a preserved ejection fraction (HFpEF), a highly morbid syndrome with very few effective treatments. HFpEF is historically associated with hypertension […]
Right Atrial Pacing to Improve Acute Hemodynamics in Pulmonary Arterial Hypertension
Posted by | Article of the WeekARTICLE: Right Atrial Pacing to Improve Acute Hemodynamics in Pulmonary Arterial Hypertension AUTHORS: Jasjeet S Khural, Brian A Houston, Peter J Leary, Stephen C Mathai, Todd M Kolb, Rachel Damico, Paul M Hassoun, David A Kass, Steven Hsu, Ryan J Tedford JOURNAL: Am J Respir Crit Care Med. 2020 Oct 7. doi: 10.1164/rccm.202006-2278LE. Online ahead of print. Right atrial (RA) pacing to increase heart rate is […]
Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review
Posted by | Article of the WeekARTICLE: Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review AUTHORS: Richard Ferraro, Jacqueline M. Latina, Abdulhamied Alfaddagh, Erin D. Michos, Michael J. Blaha, Steven R. Jones, Garima Sharma, Jeffrey C. Trost, William E. Boden, William S. Weintraub, João A.C. Lima, Roger S. Blumenthal, Valentin Fuster, Armin Arbab-Zadeh JOURNAL: J Am Coll […]
Survivorship after COVID-19 ICU stay
Posted by | Article of the WeekARTICLE: Survivorship after COVID-19 ICU stay AUTHORS: Megan M. Hosey and Dale M. Needham JOURNAL: Nat Rev Dis Primers. 2020; 6(1): 60. Abstract Our understanding of the epidemiology of the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection and associated COVID-19 illness continues to evolve. Statistics from early in the pandemic indicate that ~1 in 5 […]
Neoadjuvant checkpoint blockade for cancer immunotherapy
Posted by | Article of the WeekARTICLE: Neoadjuvant checkpoint blockade for cancer immunotherapy AUTHORS: Suzanne L Topalian, Janis M Taube, Drew M Pardoll JOURNAL: Science. 2020 Jan 31;367(6477):eaax0182. doi: 10.1126/science.aax0182. Abstract BACKGROUND: Immunotherapies that target the interaction of programmed death 1 (PD-1) with its ligands, PD-L1 and PD-L2, have ushered in the modern oncology era. The PD-1 pathway is a key mediator of local […]
Social Determinants of Health and Diabetes: A Scientific Review
Posted by | Article of the WeekARTICLE: Social Determinants of Health and Diabetes: A Scientific Review AUTHORS: Felicia Hill-Briggs, Nancy E Adler, Seth A Berkowitz, Marshall H Chin, Tiffany L Gary-Webb, Ana Navas-Acien, Pamela L Thornton, Debra Haire-Joshu JOURNAL: Diabetes Care. 2020 Nov 2;dci200053. doi: 10.2337/dci20-0053. Online ahead of print. Decades of research have demonstrated that diabetes affects racial and ethnic minority and low-income adult populations in the U.S. disproportionately, […]
Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm
Posted by | Article of the WeekARTICLE: Evaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm AUTHORS: Richard Ferraro, Jacqueline M. Latina, Abdulhamied Alfaddagh, Erin D. Michos, Michael J. Blaha, Steven R. Jones, Garima Sharma, Jeffrey C. Trost, William E. Boden, William S. Weintraub, João A.C. Lima, Roger S. Blumenthal, Valentin Fuster, Armin Arbab-Zadeh JOURNAL: J Am Coll […]
Myocardial Gene Expression Signatures in Human Heart Failure with Preserved Ejection Fraction
Posted by | Article of the WeekARTICLE: Myocardial Gene Expression Signatures in Human Heart Failure with Preserved Ejection Fraction AUTHORS: Virginia S. Hahn, Hildur Knutsdottir, Xin Luo, Kenneth Bedi, Kenneth B. Margulies, Saptarsi M. Haldar, Maria Stolina, Jun Yin, Aarif Y. Khakoo, Joban Vaishnav, Joel S. Bader, David A. Kass, and Kavita Sharma JOURNAL: Circulation. 2020 Oct 29. doi: 10.1161/CIRCULATIONAHA.120.050498. Online ahead of print. Abstract Background: Heart failure with preserved ejection fraction (HFpEF) constitutes […]