Article of the Week

Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease

Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease

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ARTICLE: Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease. AUTHORS: Casey M. Rebholz, Elizabeth Selvin, Menglu Liang, Christie M. Ballantyne, Ron C. Hoogeveen, David Aguilar, John W. McEvoy, Morgan E. Grams, Josef Coresh JOURNAL: Kidney Int. 2017 Aug 30. pii: S0085-2538(17)30497-0. doi: 10.1016/j.kint.2017.06.028. [Epub ahead of print] Abstract Galectin-3 has been(...)

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Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

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ARTICLE: Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy AUTHORS: Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman and Anthony Cammarato JOURNAL: Cell Repots. 2017 Sep. Abstract Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks(...)

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Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

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ARTICLE: Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association AUTHORS: Deborah Young-Hyman, Mary de Groot, Felicia Hill-Briggs, Jeffrey Gonzalez, Korey Hood and Mark Peyrot JOURNAL: Diabetes Care. 2017 Sep;40(9):e131-e132. doi: 10.2337/dci16-0051. Thanks to Drs. Kalra, Balhara, Mezuk, Pouwer, and Campbell and Ms. Macdonald for(...)

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Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women

Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women

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ARTICLE: Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women AUTHORS: Roy M. Gulick, Timothy J. Wilkin, Ying Q. Chen, Raphael J. Landovitz, K. Rivet Amico, Alicia M. Young, Paul Richardson, Mark A. Marzinke, Craig W. Hendrix, Susan H. Eshleman, Ian McGowan, Leslie M. Cottle, Adriana Andrade, Cheryl Marcus, Karin L. Klingman,(...)

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

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ARTICLE: Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice. AUTHORS: Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal, Peter P. Rainer, Julia G. Bindman, Elizabeth E. Gerber, Djahida Bedja, Christopher Schiefer, Karen L. Miller, Guangshuo Zhu, Loretha Myers, Nuria Amat-Alarcon, Dong I. Lee, Norimichi Koitabashi, Daniel P. Judge, David A. Kass and Harry C. Dietz JOURNAL: JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588.(...)

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A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure

A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure

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ARTICLE: A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure AUTHORS: Zackary D. Goff, Andrew B. Kichura, John T. Chibnall, Paul J. Hauptman JOURNAL: JAMA Intern Med. 2017 Jul 24. doi: 10.1001/jamainternmed.2017.2988. [Epub ahead of print] Abstract Stem cell therapy for the treatment of heart failure (HF) is under investigation but not approved by the US(...)

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Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

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ARTICLE: Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults. AUTHORS: Stephen P. Juraschek, Natalie Daya, Andreea M. Rawlings, Lawrence J. Appel, Edgar R. Miller III, B. Gwen Windham, Michael E. Griswold, Gerardo Heiss, Elizabeth Selvin JOURNAL: JAMA Intern Med. 2017 Jul 24. doi: 10.1001/jamainternmed.2017.2937. [Epub ahead of print] Abstract IMPORTANCE: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after(...)

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

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ARTICLE: Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice AUTHORS: Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal, Peter P. Rainer, Julia G. Bindman, Elizabeth E. Gerber, Djahida Bedja, Christopher Schiefer, Karen L. Miller, Guangshuo Zhu, Loretha Myers, Nuria Amat-Alarcon, Dong I. Lee, Norimichi Koitabashi, Daniel P. Judge, David A. Kass and Harry C. Dietz JOURNAL: JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. [Epub(...)

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Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

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ARTICLE: Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration AUTHORS: E. Fabian Cardozo, Adriana Andrade, John W. Mellors, Daniel R. Kuritzkes, Alan S. Perelson, Ruy M. Ribeiro JOURNAL: PLoS Pathog. 2017 Jul 5;13(7):e1006478. doi: 10.1371/journal.ppat.1006478. eCollection 2017 Jul. Abstract The kinetics of HIV-1 decay under treatment depends(...)

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Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review

Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review

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ARTICLE: Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review AUTHORS: Carl G. Streed Jr., Omar Harfouch, Francoise Marvel, Roger S. Blumenthal, Seth S. Martin, Monica Mukherjee JOURNAL: Ann Intern Med. 2017 Jul 25. doi: 10.7326/M17-0577. [Epub ahead of print] Abstract Recent reports estimate that 0.6% of adults in the United States, or approximately 1.4 million persons, identify(...)

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