Sharing successes, challenges and daily happenings in the Department of Medicine
ARTICLE: Trends in Use of High-Dose Vitamin D Supplements Exceeding 1000 or 4000 International Units Daily, 1999-2014 AUTHORS: Mary R. Rooney, Lisa Harnack, Erin D. Michos, Rachel P. Ogilvie, Christopher T. Sempos, Pamela L. Lutsey JOURNAL: JAMA. 2017 Jun 20;317(23):2448-2450. doi: 10.1001/jama.2017.4392. Since 2000, there has been an increase in research on possible health benefits of vitamin D. However, a 2011 Institute of Medicine (IOM; now the(...)
ARTICLE: Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol during Sleep. AUTHORS: Swati Chopra, Aman Rathore, Haris Younas, Luu V. Pham, Chenjuan Gu, Aleksandra Beselman, Il-Young Kim, Robert R. Wolfe, Jamie Perin, Vsevolod Y. Polotsky, Jonathan C. Jun JOURNAL: J Clin Endocrinol Metab. 2017 Jun 8. doi: 10.1210/jc.2017-00619. [Epub ahead of print] Abstract CONTEXT: Obstructive sleep apnea (OSA) is associated with diabetes and cardiovascular disease. This association(...)
ARTICLE: Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. AUTHORS: Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn JOURNAL: Circulation. 2017 Jun 15. pii: CIR.0000000000000510. doi: 10.1161/CIR.0000000000000510. Abstract Cardiovascular disease (CVD) is the leading(...)
ARTICLE: Using Trial Eligibility to Personalize Statin Therapy Appears No More Accurate Than a Coin Flip in Determining High-Risk Status* AUTHORS: Roger S. Blumenthal, M. Imran Aslam, William McEvoy JOURNAL: JACC Cardiovasc Imaging. 2017 Jun 9. pii: S1936-878X(17)30403-5. doi: 10.1016/j.jcmg.2017.02.019. [Epub ahead of print] Is it possible that around one-half of middle-aged adults estimated to be(...)
ARTICLE: How we treat central venous access device-related upper extremity DVT AUTHORS: Anita Rajasekhar and Michael B. Streiff JOURNAL: Blood 2017 :blood-2016-08-693671; doi: https://doi.org/10.1182/blood-2016-08-693671 Abstract Central venous access device (CVAD)-related thrombosis (CRT) is a common complication among patients requiring central venous access as part of their medical care. Complications of CRT include pulmonary embolism, recurrent deep venous thrombosis, loss of central venous(...)
ARTICLE: Myeloproliferative Neoplasms AUTHORS: Jerry L. Spivak JOURNAL: N Engl J Med. 2017 Jun 1; 376:2168-2181. doi: 10.1056/NEJMra1406186 The myeloproliferative neoplasms — polycythemia vera, essential thrombocytosis, and primary myelofibrosis — are unique hematopoietic stem-cell disorders that share mutations that constitutively activate the physiologic signal-transduction pathways responsible for hematopoiesis. Consequently, these disorders engage in phenotypic mimicry(...)
ARTICLE: Older Adults' Views and Communication Preferences About Cancer Screening Cessation AUTHORS: Nancy L. Schoenborn, Kimberley Lee, Craig E. Pollack, Karen Armacost, Sydney M. Dy, John F. P. Bridges, Qian-Li Xue, Antonio C. Wolff, Cynthia Boyd JOURNAL: JAMA Intern Med. 2017 Jun 12. doi: 10.1001/jamainternmed.2017.1778. [Epub ahead of print] Abstract IMPORTANCE: Older adults with limited life expectancy are frequently screened for cancer even though it exposes them to risks of screeningwith minimal benefit. Patient preferences may be an important contributor to continued screening. OBJECTIVE: To examine older adults' views on the(...)
ARTICLE: Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes AUTHORS: Annika S. Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A. Nenonen, Yunzhao Tang, Jed W. Fahey, Jonathan M. J. Derry, Claes B. Wollheim, Nils Wierup, Morey W. Haymond, Stephen H. Friend, Hindrik Mulder and Anders H. Rosengren JOURNAL: Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477. Abstract A potentially useful(...)
ARTICLE: Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs AUTHORS: Abraham J. Kandathil, Florian P. Breitwieser, Jaiprasath Sachithanandham, Matthew Robinson, Shruti H. Mehta, Winston Timp, Steven L. Salzberg, David L. Thomas, Ashwin Balagopal JOURNAL: Ann Intern Med. 2017 Jun 6. doi: 10.7326/M17-0085. [Epub ahead of print] Abstract Background: Next-generation metagenomic sequencing (NGMS)(...)
ARTICLE: Looking Beyond the Tip of a Tusk: Balancing the Evidence in Prognosis-related Communication. AUTHORS: Rebecca A Aslakson and Mary Catherine Beach JOURNAL: Am J Respir Crit Care Med. 2017 May 16. doi: 10.1164/rccm.201704-0851ED. [Epub ahead of print] Evidence supports a poor prognosis for patients with chronic critical illness; 30- 40% die prior to hospital discharge, and another(...)