Article of the Week

Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies

Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies

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ARTICLE: Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies AUTHORS: Abdulla A. Damluji, Daniel W. Nelson, Marco Valgimigli, Stephan Windecker, Robert A. Byrne, Fernando Cohen, Tejas Patel, Emmanouil S. Brilakis, Subhash Banerjee, Jorge Mayol, Warren J. Cantor, Carlos E. Alfonso, Sunil V. Rao, Mauro Moscucci and Mauricio G. Cohen JOURNAL: JACC Cardiovasc Interv. 2017 Nov 27;10(22):2269-2279. doi: 10.1016/j.jcin.2017.08.035. Abstract OBJECTIVES: The aim of this study was to examine the current practice and(...)

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Treatment concentration of high-sensitivity C-reactive protein

Treatment concentration of high-sensitivity C-reactive protein

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ARTICLE: Treatment concentration of high-sensitivity C-reactive protein AUTHORS: Erin D. Michos, Roger S. Blumenthal JOURNAL: Lancet. 2017 Nov 13. pii: S0140-6736(17)32865-9. doi: 10.1016/S0140-6736(17)32865-9. [Epub ahead of print] The landmark CANTOS trial evaluated the use of canakinumab, a monoclonal antibodytargeting interleukin 1β, in 10 061 patients with previous myocardial infarction who had high-sensitivity C-reactive protein (hsCRP) concentrations of 2 mg/L or higher.1 Interleukin 1β has multiple(...)

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A tripartite complex of suPAR, APOL1 risk variants and integrin on podocytes mediates chronic kidney disease

A tripartite complex of suPAR, APOL1 risk variants and integrin on podocytes mediates chronic kidney disease

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ARTICLE: A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease AUTHORS: Salim S Hayek, Kwi Hye Koh, Morgan E Grams, Changli Wei, Yi-An Ko, Jing Li, Beata Samelko, Hyun Lee, Ranadheer R Dande, Ha Won Lee, Eunsil Hahm, Vasil Peev, Melissa Tracy, Nicholas J Tardi, Vineet Gupta(...)

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Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study

Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study

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ARTICLE: Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study AUTHORS: Elizabeth Selvin, Dan Wang, Alexandra K. Lee, Richard M. Bergenstal, Josef Coresh JOURNAL: Ann Intern Med. 2017 Oct 24. doi: 10.7326/M17-1272. [Epub ahead of print] Abstract Background: A common belief is that one quarter to one third of all(...)

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Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial

Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial

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ARTICLE: Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial  AUTHORS: John W. McEvoy, Khalil Ibrahim, Thomas S. Kickler, William A. Clarke, Rani K. Hasan, Matthew J. Czarny, Ali R. Keramati, Rakesh R. Goli, Travis P. Gratton, Jeffrey A. Brinker, Matthews Chacko, Chao-Wei Hwang, Peter V. Johnston, Julie M. Miller, Jeffrey C. Trost, William R. Herzog, Roger S. Blumenthal, David(...)

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Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing

Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing

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ARTICLE: Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing AUTHORS: Kevin P. Eaton, Kathryn Levy, Christine Soong, Amit K. Pahwa, Christopher Petrilli, Justin B. Ziemba, Hyung J. Cho, Rodrigo Alban, Jaime F. Blanck, Andrew S. Parsons JOURNAL: JAMA Intern Med. 2017 Oct 16. doi: 10.1001/jamainternmed.2017.5152. [Epub ahead of print] Abstract Routine daily laboratory testing of hospitalized patients reflects a wasteful clinical practice that threatens the value of health care. Choosing Wisely initiatives from numerous professional societies have identified repetitive laboratory testing in the(...)

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Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans

Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans

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ARTICLE: Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans AUTHORS: Joshua J. Joseph, Justin B. Echouffo-Tcheugui, Rita R. Kalyani, Hsin-Chieh Yeh, Alain G. Bertoni, Valery S. Effoe,  Ramon Casanova, Mario Sims, Wen-Chih Wu, Gary S. Wand, Adolfo Correa, Sherita H. Golden JOURNAL: JACC Heart Fail. 2017 Sep;5(9):642-651. doi: 10.1016/j.jchf.2017.05.012. Epub 2017 Aug 16. Abstract(...)

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Is There Merit in Merit Aid?

Is There Merit in Merit Aid?

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ARTICLE: Is There Merit in Merit Aid? AUTHORS: Roy C. Ziegelstein, Charles G. Prober, Lloyd B. Minor, George Q. Daley, Paul B. Rothman, and Edward M. Hundert JOURNAL: N Engl J Med. 2017 Oct 25. doi: 10.1056/NEJMp1713146. [Epub ahead of print] In 2016, the average cost of attending medical school (including tuition and fees) in the(...)

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Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

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ARTICLE: Association of Mitochondrial DNA Copy Number With Cardiovascular Disease AUTHORS: Foram N. Ashar, Yiyi Zhang, Ryan J. Longchamps, John Lane, Anna Moes, Megan L. Grove, Josyf C. Mychaleckyj, Kent D. Taylor, Josef Coresh, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Eliseo Guallar, Dan E. Arking JOURNAL: JAMA Cardiol. 2017 Oct 11. doi: 10.1001/jamacardio.2017.3683. [Epub ahead of print] Abstract IMPORTANCE: Mitochondrial dysfunction is a core component of the aging process and may play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number (mtDNA-CN), which represents the number of mitochondria(...)

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Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

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ARTICLE: Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults AUTHORS: Stephen P. Juraschek, Natalie Daya, Andreea M. Rawlings, Lawrence J. Appel, Edgar R. Miller III, B. Gwen Windham, Michael E. Griswold, Gerardo Heiss, Elizabeth Selvin JOURNAL: JAMA Intern Med. 2017 Sep 1;177(9):1316-1323. doi: 10.1001/jamainternmed.2017.2937. Abstract IMPORTANCE: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after rising from supine to(...)

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