Article of the Week

Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

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ARTICLE: Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules AUTHORS: Jeffrey H. Silber, Lisa M. Bellini, Judy A. Shea, Sanjay V. Desai, David F. Dinges, Mathias Basner, Orit Even-Shoshan, Alexander S. Hill, Lauren L. Hochman, Joel T. Katz, Richard N. Ross, David M. Shade, Dylan S. Small, Alice L. Sternberg, James Tonascia, Kevin G. Volpp, and David A. Asch for the iCOMPARE Research Group JOURNAL:(...)

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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

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ARTICLE: Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity AUTHORS: Ling Li*, Hildur Knutsdottir, Ken Hui*, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Joel S. Bader and Florin M. Selaru JOURNAL: JCI Insight. 2019 Jan 24;4(2). pii: 121490. doi: 10.1172/jci.insight.121490. [Epub ahead of print] Abstract Liver cancer is the fourth leading cause of cancer-related mortality and(...)

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Caring for Patients With Multiple Chronic Conditions

Caring for Patients With Multiple Chronic Conditions

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ARTICLE: Caring for Patients With Multiple Chronic Conditions AUTHORS: Mary E. Tinetti, Ariel R. Green, Jennifer Ouellet, Michael W. Rich, Cynthia Boyd JOURNAL: Ann Intern Med. 2019 Jan 22. doi: 10.7326/M18-3269. [Epub ahead of print] Multimorbidity, the coexistence of multiple chronic conditions, is common among all adults receiving health care and the norm among older adults.(...)

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Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

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ARTICLE: Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability AUTHORS: Lindsay F. Rizzardi, Peter F. Hickey, Varenka Rodriguez DiBlasi, Rakel Tryggvadóttir, Colin M. Callahan, Adrian Idrizi, Kasper D. Hansen & Andrew P. Feinberg  JOURNAL: Nat Neurosci. 2019 Feb;22(2):307-316. doi: 10.1038/s41593-018-0297-8. Epub 2019 Jan 14. Abstract Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain(...)

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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

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ARTICLE: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress AUTHORS: Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee & David A. Kass JOURNAL: Nature. 2019 Jan 30. doi: 10.1038/s41586-019-0895-y. [Epub ahead of print] Brief Summary Protein kinase G has long been considered to provide protection against(...)

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Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study

Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study

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ARTICLE: Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study AUTHORS: Zhixiong Wang, Swetha Kambhampati, Yulan Cheng, Ke Ma, Cem Simsek, Alan H Tieu, John M Abraham, Xi Liu, Vishnu Prasath, Mark D Duncan, Alejandro Stark, Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He, Mouen A Khashab, Saowanee Ngamruengphong, Eun J Shin, Tza-Huei Wang and Stephen J. Meltzer JOURNAL: Clin Cancer Res. 2019 Jan 22. pii: clincanres.3696.2018. doi: 10.1158/1078-0432.CCR-18-3696. [Epub ahead of print] Abstract PURPOSE: Barrett's esophagus (BE) is the only known precursor of esophageal adenocarcinoma (EAC). Although endoscopy and biopsy(...)

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Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use

Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use

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ARTICLE: Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use AUTHORS: Alexandra T. Strauss, Theodore W. James and Simon C. Mathews JOURNAL: Gastroenterology. 2018 Dec;155(6):2014-2015. doi: 10.1053/j.gastro.2018.08.034. Epub 2018 Aug 27. The number and complexity of procedures performed by gastroenterologists are increasing in the United States. In addition, the(...)

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Substance-Use Disorders in Later Life

Substance-Use Disorders in Later Life

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ARTICLE: Substance-Use Disorders in Later Life AUTHORS: Susan W. Lehmann and Michael Fingerhood JOURNAL: NEJM. 2018 Dec 13.doi: 10.1056/NEJMra1805981 Substance-use disorders have been declared a national public health emergency.1 Although the rates of substance use are generally lower among older adults than among younger people, this review focuses on older adults.2 Physiological changes in hepatic metabolism that occur(...)

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Rural Residence and Poverty are Independent Risk Factors for COPD in the United States

Rural Residence and Poverty are Independent Risk Factors for COPD in the United States

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ARTICLE: Rural Residence and Poverty are Independent Risk Factors for COPD in the United States AUTHORS: Sarath Raju, Corinne A Keet, Laura M Paulin, Elizabeth C Matsui, Roger D Peng, Nadia N Hansel and Meredith C McCormack JOURNAL: Am J Respir Crit Care Med. 2018 Nov 2. doi: 10.1164/rccm.201807-1374OC. [Epub ahead of print] Abstract RATIONALE: In developing countries, poor and rural areas have a(...)

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Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?

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ARTICLE: Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner? AUTHORS: Thomaz Fleury Curado, Slava Berger and Vsevolod Y Polotsky JOURNAL: Am J Respir Crit Care Med. 2018 Dec 6. doi: 10.1164/rccm.201811-2135ED. [Epub ahead of print] Obstructive sleep apnea (OSA) is recurrent upper airway obstruction caused by a loss of upper airway muscle tone during sleep, which(...)

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