Article of the Week

Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension

Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension

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ARTICLE: Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension AUTHORS: Valentina Mercurio, Monica Mukherjee, Ryan J. Tedford, Roham T. Zamanian, Rubina M. Khair, Takahiro Sato, Omar A. Minai, Fernando Torres, Reda E. Girgis, Kelly Chin, Rachel Damico, Todd M. Kolb, Stephen C. Mathai and Paul M. Hassoun JOURNAL: Am J Respir Crit Care Med. 2018 Feb 1;197(3):388-391. doi: 10.1164/rccm.201704-0789LE. To the Editor: Scleroderma-associated pulmonary arterial hypertension (SSc-PAH) is characterized by poor survival,(...)

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Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension

Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension

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ARTICLE: Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension AUTHORS: Steven Hsu, Kristen M. Kokkonen-Simon, Jonathan A. Kirk, Todd M. Kolb, Rachel L. Damico, Stephen C. Mathai, Monica Mukherjee, Ami A. Shah, Fredrick M. Wigley, Kenneth B. Margulies, Paul M. Hassoun, Marc K. Halushka, Ryan J. Tedford, David A Kass JOURNAL: Circulation. 2018 Jan 19. pii: CIRCULATIONAHA.117.033147. doi: 10.1161/CIRCULATIONAHA.117.033147. [Epub ahead of(...)

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Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg

Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg

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ARTICLE: Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg AUTHORS: Jason M Elinoff, Richa Agarwal, Christopher F Barnett, Raymond L Benza, Michael J Cuttica, Ahmed M. Gharib, Michael P Gray, Paul M Hassoun, Anna R Hemnes, Marc Humbert, Todd M Kolb, Tim Lahm, Jane A Leopold, Stephen C Mathai, Vallerie V McLaughlin, Ioana R Preston, Erika B Rosenzweig, Oksana A Shlobin, Virginia D Steen, Roham T Zamanian and Michael A. Solomon JOURNAL: Am J Respir Crit Care Med. 2018 Feb(...)

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Association between Household Air Pollution Exposure and Chronic Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-Income Country Settings

Association between Household Air Pollution Exposure and Chronic Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-Income Country Settings

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ARTICLE: Association between Household Air Pollution Exposure and Chronic Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-Income Country Settings AUTHORS: Trishul Siddharthan, Matthew R. Grigsby, Dina Goodman, Muhammad Chowdhury, Adolfo Rubinstein, Vilma Irazola, Laura Gutierrez, J. Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert Jones, Frederick van Gemert, Robert A. Wise, and William Checkley JOURNAL: Am J Respir Crit Care Med. 2018 Mar 1;197(5):611-620. doi: 10.1164/rccm.201709-1861OC. Abstract RATIONALE:(...)

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Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine

Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine

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The educational outcomes from the iCOMPARE trial were published last week in the New England Journal of Medicine. iCOMPARE tested flexibility in duty hour policies in internal medicine residency. Sixty-three programs were randomized to 2011 rules or more flexible rules that had no limits in continuous hours of work and no mandatory minimums for time(...)

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Long-acting injectable atovaquone nanomedicines for malaria prophylaxis

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis

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ARTICLE: Long-acting injectable atovaquone nanomedicines for malaria prophylaxis AUTHORS: Rahul P. Bakshi, Lee M. Tatham, Alison C. Savage, Abhai K. Tripathi, Godfree Mlambo, Matthew M. Ippolito, Elizabeth Nenortas, Steve P. Rannard, Andrew Owen and Theresa A. Shapiro JOURNAL: Nat Commun. 2018 Jan 22;9(1):315. doi: 10.1038/s41467-017-02603-z. Abstract Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles(...)

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Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer

Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer

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ARTICLE: Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer AUTHORS: Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K. Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J. O’Neill, Mark S. Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, and Mingzhao Xing JOURNAL: J Clin Oncol. 2018 Feb 10;36(5):438-445. doi: 10.1200/JCO.2017.74.5497. Epub 2017 Dec 14. Abstract Purpose(...)

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Single-board hematology fellowship track: a 10-year institutional experience

Single-board hematology fellowship track: a 10-year institutional experience

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ARTICLE: Single-board hematology fellowship track: a 10-year institutional experience AUTHORS: Rakhi P. Naik, Kristen Marrone, Samuel Merrill, Ross Donehower and Robert Brodsky JOURNAL: Blood. 2018 Jan 25;131(4):462-464. doi: 10.1182/blood-2017-11-816207. Epub 2017 Dec 11. TO THE EDITOR: In the United States, internal medicine subspecialty training is dictated primarily by the Accreditation Council for Graduate Medical Education (ACGME), which sets standards for clinical and education program requirements for recognized fellowships. For adult hematology and(...)

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An Implementation Guide to Reducing Overtreatment of Asymptomatic Bacteriuria

An Implementation Guide to Reducing Overtreatment of Asymptomatic Bacteriuria

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ARTICLE: An Implementation Guide to Reducing Overtreatment of Asymptomatic Bacteriuria AUTHORS: Michael Daniel, Sara Keller, Mohammad Mozafarihashjin, Amit Pahwa, Christine Soong JOURNAL: JAMA Intern Med. 2018 Feb 1;178(2):271-276. doi: 10.1001/jamainternmed.2017.7290. Abstract Treatment of asymptomatic bacteriuria (ASB) frequently lacks appropriate indication, yet remains prevalent across settings. Numerous guidelines, professional societies, and campaigns such as Choosing Wisely advocate against this low-value practice. Efforts aimed at reducing unnecessary treatment of ASB demonstrate improved(...)

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Impact of Novel LDL-C Assessment on the Utility of Secondary Non-HDL-C and ApoB Targets in Selected Worldwide Dyslipidemia Guidelines

Impact of Novel LDL-C Assessment on the Utility of Secondary Non-HDL-C and ApoB Targets in Selected Worldwide Dyslipidemia Guidelines

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ARTICLE: Impact of Novel LDL-C Assessment on the Utility of Secondary Non-HDL-C and ApoB Targets in Selected Worldwide Dyslipidemia Guidelines AUTHORS: Vasanth Sathiyakumar, Jihwan Park, Renato Quispe, Mohamed B. Elshazly, Erin D. Michos, Maciej Banach, Peter P. Toth, Seamus P. Whelton, Roger S. Blumenthal, Steven R. Jones, Seth S. Martin JOURNAL: Circulation. 2018 Mar 5. pii: CIRCULATIONAHA.117.032463. doi: 10.1161/CIRCULATIONAHA.117.032463. [Epub ahead of print] Abstract BACKGROUND: Selected(...)

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