Article of the Week

Relation between alcohol consumption in midlife and dementia in late life

Relation between alcohol consumption in midlife and dementia in late life

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ARTICLE: Relation between alcohol consumption in midlife and dementia in late life AUTHOR: Sevil Yasar JOURNAL: BMJ. 2018 Aug 1;362:k3164. doi: 10.1136/bmj.k3164. Alzheimer’s disease is a rapidly growing clinical and public health problem with currently no disease modifying therapies to treat or prevent the disease.1 Research suggests that pathological changes precede clinical symptoms by decades,2 resulting in an(...)

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Which way does the axis tip? IBD increases the risk of Parkinson’s disease

Which way does the axis tip? IBD increases the risk of Parkinson’s disease

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ARTICLE: Which way does the axis tip? IBD increases the risk of Parkinson’s disease AUTHORS: Susan Hutfless and Gregor K Wenning JOURNAL: Gut. 2018 Jun 1. pii: gutjnl-2018-316537. doi: 10.1136/gutjnl-2018-316537. [Epub ahead of print] In Gut, Villumsen et al1 report a statistically significant association between UC and the risk of parkinsonism in a Danish nested case–control study. Patients with Crohn’s(...)

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Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latin American immigrants in deportation proceedings

Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latin American immigrants in deportation proceedings

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ARTICLE: Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latin American immigrants in deportation proceedings AUTHORS: Kathleen R Page, Suzanne Dolwick Grieb, Karen Nieves-Lugo, Thespina Yamanis, Holly Taylor, Omar Martinez, Yoshiaki Yamasaki, Rupali Limaye, Wendy Davis, Chris Beyrer, María Cecilia Zea JOURNAL: Lancet HIV. 2018 Jul 6. pii: S2352-3018(18)30074-2. doi: 10.1016/S2352-3018(18)30074-2.(...)

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Acute Cardiac Effects of Severe Pre-Eclampsia

Acute Cardiac Effects of Severe Pre-Eclampsia

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ARTICLE: Acute Cardiac Effects of Severe Pre-Eclampsia AUTHORS: Arthur Jason Vaught, Lara C. Kovell, Linda M. Szymanski, Susan A. Mayer, Sara M. Seifert, Dhananjay Vaidya, Jamie D. Murphy, Cynthia Argani, Anna O’Kelly, Sarah York, Pamela Ouyang, Monica Mukherjee, Sammy Zakaria JOURNAL: J Am Coll Cardiol. 2018 Jul 3;72(1):1-11. doi: 10.1016/j.jacc.2018.04.048. Abstract BACKGROUND: Pre-eclampsia with severe features (PEC) is a(...)

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Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

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ARTICLE: Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure AUTHORS: Swati Dey, Deeptankar DeMazumder, Agnieszka Sidor, D. Brian Foster, Brian O’Rourke JOURNAL: Circ Res. 2018 Jun 13. pii: CIRCRESAHA.118.312708. doi: 10.1161/CIRCRESAHA.118.312708. [Epub ahead of print] Abstract Rationale: Despite increasing prevalence and incidence of heart failure (HF), therapeutic options remain limited. In early stages of HF, sudden cardiac death (SCD)(...)

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Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

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ARTICLE: Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease AUTHORS: Emmanouil Tampakakis, Sanjiv J. Shah, Barry A. Borlaug, Peter J. Leary, Harnish H. Patel, Wayne L. Miller, Benjamin W. Kelemen, Brian A. Houston, Todd M. Kolb, Rachel Damico, Stephen C. Mathai, Edward K. Kasper, Paul M. Hassoun, David A. Kass, Ryan J. Tedford JOURNAL: Circ Heart Fail. 2018 Apr;11(4):e004436. doi: 10.1161/CIRCHEARTFAILURE.117.004436. Abstract BACKGROUND: Patients with combined post- and precapillary pulmonary hypertension due to left heart disease have a worse prognosis compared with isolated(...)

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Cumulative blood pressure from early adulthood to middle age is associate with left atrial remodelling and subclinical dysfunction assessed by three-dimensional echocardiography: a prospective post hoc analysis from the coronary artery risk development in young adults study

Cumulative blood pressure from early adulthood to middle age is associate with left atrial remodelling and subclinical dysfunction assessed by three-dimensional echocardiography: a prospective post hoc analysis from the coronary artery risk development in young adults study

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ARTICLE: Cumulative blood pressure from early adulthood to middle age is associated with left atrial remodelling and subclinical dysfunction assessed by three-dimensional echocardiography: a prospective post hoc analysis from the coronary artery risk development in young adults study AUTHORS: Henrique D Vasconcellos, Henrique T Moreira, Luisa Ciuffo, Chike C Nwabuo, Guilherme S Yared, Bharath Ambale-Venkatesh, Anderson C Armstrong, Satoru Kishi, Jared P Reis, Kiang Liu, Donald M Lloyd-Jones, Laura A Colangelo, Pamela J Schreiner, Stephen Sidney, Samuel S Gidding(...)

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Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences

Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences

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ARTICLE: Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences AUTHORS: Alex D. Federman, Tacara Soones, Linda V. DeCherrie, Bruce Leff, Albert L. Siu JOURNAL: JAMA Intern Med. 2018 Jun 25. doi:10.1001/jamainternmed.2018.2562 Abstract Importance: Hospital-at-home (HaH) care provides acute hospital-level care in a patient’s home as a substitute(...)

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Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation

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ARTICLE: Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation Insights From the FOURIER Trial AUTHORS: Seth S. Martin, Robert P. Giugliano, Sabina A. Murphy, Scott M. Wasserman, Evan A. Stein, Richard Češka, José López-Miranda, Borislav Georgiev, Alberto J. Lorenzatti, Matti J. Tikkanen, Peter S. Sever, Anthony C. Keech, Terje R. Pedersen, Marc S. Sabatine JOURNAL: JAMA Cardiol. 2018 Jun 13. doi: 10.1001/jamacardio.2018.1533. [Epub ahead of print] Abstract IMPORTANCE: Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which(...)

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Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA

Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA

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ARTICLE: Rates of infection after colonoscopy and osophagogastroduodenoscopy in ambulatory surgery centres in the USA AUTHORS: Peiqi Wang, Tim Xu, Saowanee Ngamruengphong, Martin Makary, Anthony Kalloo, Susan Hutfless JOURNAL: Gut. 2018 May 18. pii: gutjnl-2017-315308. doi: 10.1136/gutjnl-2017-315308. [Epub ahead of print] Abstract OBJECTIVE: Over 15 million colonoscopies and 7 million osophagogastroduodenoscopies (OGDs) are performed annually in the USA. We aimed to estimate the(...)

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