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Medicine Matters

Sharing successes, challenges and daily happenings in the Department of Medicine

Article of the Week

Impact of recipient age on mortality among Cytomegalovirus (CMV)-seronegative lung transplant recipients with CMV-seropositive donors

ARTICLE: Impact of recipient age on mortality among Cytomegalovirus (CMV)-seronegative lung transplant recipients with CMV-seropositive donors AUTHORS: Sara Belga, Sarah Hussain, Robin K Avery, Zeba Nauroz, Christine M Durand, Elizabeth… Read More »Impact of recipient age on mortality among Cytomegalovirus (CMV)-seronegative lung transplant recipients with CMV-seropositive donors

Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection

ARTICLE: Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection AUTHORS: Nicole Frumento, Ariadne Sinnis-Bourozikas, Harry T… Read More »Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II)

ARTICLE: Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II) AUTHORS: Michelle Petri, Ian N Bruce, Thomas Dörner, Yoshiya Tanaka, Eric… Read More »Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II)

Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones

ARTICLE: Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones AUTHORS: Filippo Dragoni, Abena K Kwaa, Caroline C Traut, Rebecca T Veenhuis, Bezawit… Read More »Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones

MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

ARTICLE: MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival AUTHORS: C Korin Bullen, Alok K Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William… Read More »MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

ARTICLE: Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury AUTHORS: Yumeng Wen, Emily Su, Leyuan Xu, Steven Menez, Dennis G… Read More »Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

ARTICLE: Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis AUTHORS: Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D Leone, Rana Rais, Jonathan D… Read More »Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir

ARTICLE: Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir AUTHORS: Mithra R Kumar, Emily J Fray, Alexandra… Read More »Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir