Article of the Week

Delirium in Older Persons: Advances in Diagnosis and Treatment

Delirium in Older Persons: Advances in Diagnosis and Treatment

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ARTICLE: Delirium in Older Persons: Advances in Diagnosis and Treatment. AUTHORS: Esther S. Oh, Tamara G. Fong, Tammy T. Hshieh, Sharon K. Inouye JOURNAL: JAMA. 2017 Sep 26;318(12):1161-1174. doi: 10.1001/jama.2017.12067. Abstract IMPORTANCE: Delirium is defined as an acute disorder of attention and cognition. It is a common, serious, and often fatal condition among older patients. Although often underrecognized, delirium has serious adverse effects on the individual's function and quality of life, as well as broad societal(...)

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A Research Agenda for Communication Between Health Care Professionals and Patients Living With Serious Illness

A Research Agenda for Communication Between Health Care Professionals and Patients Living With Serious Illness

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ARTICLE: A Research Agenda for Communication Between Health Care Professionals and Patients Living With Serious Illness. AUTHORS: James A. Tulsky, Mary Catherine Beach, Phyllis N. Butow, Susan E. Hickman, Jennifer W. Mack, R. Sean Morrison, Richard L. Street Jr, Rebecca L. Sudore, Douglas B. White, Kathryn I. Pollak JOURNAL: JAMA Intern Med. 2017 Sep 1;177(9):1361-1366. doi: 10.1001/jamainternmed.2017.2005. Abstract IMPORTANCE: Poor communication by health care professionals contributes to physical and(...)

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Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

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ARTICLE: Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy AUTHORS: Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman, Anthony Cammarato JOURNAL: Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070. Abstract Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which(...)

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The Association of Sleep Duration and Quality with CKD Progression

The Association of Sleep Duration and Quality with CKD Progression

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ARTICLE: The Association of Sleep Duration and Quality with CKD Progression AUTHORS: Ana C. Ricardo, Kristen Knutson, Jinsong Chen, Lawrence J. Appel, Lydia Bazzano, Eunice Carmona-Powell, Janet Cohan,Manjula Kurella Tamura, Susan Steigerwalt, John Daryl Thornton,Matthew Weir, Nicolas F. Turek, Mahboob Rahman, Eve Van Cauter, James P. Lash, the Chronic Renal Insufficiency Cohort (CRIC) JOURNAL: J Am Soc Nephrol. 2017 Sep 14. pii: ASN.2016121288. doi: 10.1681/ASN.2016121288. [Epub ahead(...)

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Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease

Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease

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ARTICLE: Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease. AUTHORS: Casey M. Rebholz, Elizabeth Selvin, Menglu Liang, Christie M. Ballantyne, Ron C. Hoogeveen, David Aguilar, John W. McEvoy, Morgan E. Grams, Josef Coresh JOURNAL: Kidney Int. 2017 Aug 30. pii: S0085-2538(17)30497-0. doi: 10.1016/j.kint.2017.06.028. [Epub ahead of print] Abstract Galectin-3 has been(...)

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Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

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ARTICLE: Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy AUTHORS: Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman and Anthony Cammarato JOURNAL: Cell Repots. 2017 Sep. Abstract Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks(...)

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Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

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ARTICLE: Response to Comments on Young-Hyman et al. Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association AUTHORS: Deborah Young-Hyman, Mary de Groot, Felicia Hill-Briggs, Jeffrey Gonzalez, Korey Hood and Mark Peyrot JOURNAL: Diabetes Care. 2017 Sep;40(9):e131-e132. doi: 10.2337/dci16-0051. Thanks to Drs. Kalra, Balhara, Mezuk, Pouwer, and Campbell and Ms. Macdonald for(...)

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Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women

Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women

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ARTICLE: Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women AUTHORS: Roy M. Gulick, Timothy J. Wilkin, Ying Q. Chen, Raphael J. Landovitz, K. Rivet Amico, Alicia M. Young, Paul Richardson, Mark A. Marzinke, Craig W. Hendrix, Susan H. Eshleman, Ian McGowan, Leslie M. Cottle, Adriana Andrade, Cheryl Marcus, Karin L. Klingman,(...)

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

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ARTICLE: Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice. AUTHORS: Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal, Peter P. Rainer, Julia G. Bindman, Elizabeth E. Gerber, Djahida Bedja, Christopher Schiefer, Karen L. Miller, Guangshuo Zhu, Loretha Myers, Nuria Amat-Alarcon, Dong I. Lee, Norimichi Koitabashi, Daniel P. Judge, David A. Kass and Harry C. Dietz JOURNAL: JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588.(...)

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A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure

A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure

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ARTICLE: A Survey of Unregulated Direct-to-Consumer Treatment Centers Providing Stem Cells for Patients With Heart Failure AUTHORS: Zackary D. Goff, Andrew B. Kichura, John T. Chibnall, Paul J. Hauptman JOURNAL: JAMA Intern Med. 2017 Jul 24. doi: 10.1001/jamainternmed.2017.2988. [Epub ahead of print] Abstract Stem cell therapy for the treatment of heart failure (HF) is under investigation but not approved by the US(...)

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