Article of the Week

Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests

Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests

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ARTICLE: Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests AUTHORS: Ross A. Pollack, Siobhan P. Brown, Thomas Rea, Tom Aufderheide, David Barbic, Jason E. Buick, Jim Christenson, Ahamed H. Idris, Jamie Jasti, Michael Kampp, Peter Kudenchuk, Susanne May, Marc Muhr, Graham Nichol, Joseph P. Ornato, George Sopko, Christian Vaillancourt, Laurie Morrison, Myron Weisfeldt JOURNAL: Circulation. 2018 May 15;137(20):2104-2113. doi: 10.1161/CIRCULATIONAHA.117.030700. Epub 2018 Feb 26.(...)

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Methods for Evaluating Natural Experiments in Obesity: A Systematic Review

Methods for Evaluating Natural Experiments in Obesity: A Systematic Review

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ARTICLE: Methods for Evaluating Natural Experiments in Obesity: A Systematic Review AUTHORS: Wendy L. Bennett, Renee F. Wilson, Allen Zhang, Eva Tseng, Emily A. Knapp, Hadi Kharrazi, Elizabeth A. Stuart, Oluwaseun Shogbesan, Eric B. Bass, Lawrence J. Cheskin JOURNAL: Ann Intern Med. 2018 May 1:1-10. doi: 10.7326/M18-0309. [Epub ahead of print] Abstract BACKGROUND: Given the obesity pandemic, rigorous methodological approaches, including natural experiments,(...)

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Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

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ARTICLE: Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure AUTHORS: Peter P. Rainer, Peihong Dong, Matteo Sorge, Justyna Fert-Bober, Ronald J. Holewinski, Yuchuan Wang, Catherine A. Foss, Steven S. An, Alessandra Baracca, Giancarlo Solaini, Charles G. Glabe, Martin G. Pomper, Jennifer E. Van Eyk, Gordon F. Tomaselli, Nazareno Paolocci, Giulio Agnetti JOURNAL: Circ Res. 2018 May 11;122(10):e75-e83. doi: 10.1161/CIRCRESAHA.117.312082. Epub 2018 Feb 26. Abstract RATIONALE: Disrupted(...)

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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ARTICLE: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 AUTHORS: Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.(...)

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How to Incorporate Quality Improvement and Patient Safety Projects in Your Training

How to Incorporate Quality Improvement and Patient Safety Projects in Your Training

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ARTICLE: How to Incorporate Quality Improvement and Patient Safety Projects in Your Training AUTHORS: Shazia Mehmood Siddique, Gyanprakash Ketwaroo, Carolyn Newberry, Simon Mathews, Vandana Khungar, Shivan J. Mehta JOURNAL: Gastroenterology. 2018 May;154(6):1564-1568. doi: 10.1053/j.gastro.2018.03.044. Epub 2018 Mar 28. Abstract Engaging physicians in quality improvement (QI) and patient safety (PS) efforts has become increasingly central to creating(...)

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The Key Role of Epigenetics in Human Disease Prevention and Mitigation

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

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ARTICLE: The Key Role of Epigenetics in Human Disease Prevention and Mitigation AUTHOR: Andrew P. Feinberg JOURNAL: N Engl J Med. 2018 Apr 5;378(14):1323-1334. doi: 10.1056/NEJMra1402513. The epigenome consists of nuclear information, heritable during cell division, that controls development, tissue differentiation, and cellular responsiveness. Epigenetic information is controlled by genome sequence, environmental exposure, and stochasticity, or random chance. As(...)

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The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study

The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study

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ARTICLE: The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study AUTHORS: Christine M. Durand, Mary G. Bowring, Alvin G. Thomas, Lauren M. Kucirka, Allan B. Massie, Andrew Cameron, Niraj M. Desai, Mark Sulkowski, Dorry L. Segev JOURNAL: Ann Intern Med. 2018 Apr 17; DOI: 10.7326/M17-2451 Abstract Background: The epidemic of drug(...)

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Affordability and availability of off-patent drugs in the United States—the case for importing from abroad: observational study

Affordability and availability of off-patent drugs in the United States—the case for importing from abroad: observational study

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ARTICLE: Affordability and availability of off-patent drugs in the United States—the case for importing from abroad: observational study AUTHORS: Ravi Gupta, Thomas J Bollyky, Matthew Cohen, Joseph S Ross, Aaron S Kesselheim JOURNAL: BMJ. 2018 Mar 19;360:k831. doi: 10.1136/bmj.k831. Abstract OBJECTIVES: To evaluate whether off-patent prescription drugs at risk of sudden price increases or shortages in the United States are available from(...)

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Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome

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ARTICLE: Germline mutations in the alternative pathway of complement predispose to HELLP syndrome  AUTHORS: Arthur J. Vaught, Evan M. Braunstein, Jagar Jasem, Xuan Yuan, Igor Makhlin, Solange Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, Karin Blakemore, C. John Sperati and Robert A. Brodsky JOURNAL: JCI Insight. 2018 Mar 22;3(6). pii: 99128. doi: 10.1172/jci.insight.99128. [Epub ahead of print] Abstract BACKGROUND: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant(...)

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Detection and localization of surgically resectable cancers with a multi-analyte blood test

Detection and localization of surgically resectable cancers with a multi-analyte blood test

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ARTICLE: Detection and localization of surgically resectable cancers with a multi-analyte blood test AUTHORS: Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph H. Hruban, Christopher L. Wolfgang, Michael G. Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P. Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne(...)

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