ARTICLE: Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data AUTHORS: Dalin Rifat, Brendan Prideaux, Radojka M. Savic, Michael E. Urbanowski, Teresa L. Parsons, Brian Luna, Mark A. Marzinke, Alvaro A. Ordonez, Vincent P. DeMarco, Sanjay K. Jain, Veronique Dartois, William R. Bishai and Kelly E. Dooley JOURNAL: Sci Transl Med. 2018 Apr 4;10(435). pii: eaai7786. doi: 10.1126/scitranslmed.aai7786. Abstract In clinical trials of two rifamycin antibiotics(...)
Article of the Week
Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests
Posted by | Article of the WeekARTICLE: Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests AUTHORS: Ross A. Pollack, Siobhan P. Brown, Thomas Rea, Tom Aufderheide, David Barbic, Jason E. Buick, Jim Christenson, Ahamed H. Idris, Jamie Jasti, Michael Kampp, Peter Kudenchuk, Susanne May, Marc Muhr, Graham Nichol, Joseph P. Ornato, George Sopko, Christian Vaillancourt, Laurie Morrison, Myron Weisfeldt JOURNAL: Circulation. 2018 May 15;137(20):2104-2113. doi: 10.1161/CIRCULATIONAHA.117.030700. Epub 2018 Feb 26.(...)
Methods for Evaluating Natural Experiments in Obesity: A Systematic Review
Posted by | Article of the WeekARTICLE: Methods for Evaluating Natural Experiments in Obesity: A Systematic Review AUTHORS: Wendy L. Bennett, Renee F. Wilson, Allen Zhang, Eva Tseng, Emily A. Knapp, Hadi Kharrazi, Elizabeth A. Stuart, Oluwaseun Shogbesan, Eric B. Bass, Lawrence J. Cheskin JOURNAL: Ann Intern Med. 2018 May 1:1-10. doi: 10.7326/M18-0309. [Epub ahead of print] Abstract BACKGROUND: Given the obesity pandemic, rigorous methodological approaches, including natural experiments,(...)
Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure
Posted by | Article of the WeekARTICLE: Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure AUTHORS: Peter P. Rainer, Peihong Dong, Matteo Sorge, Justyna Fert-Bober, Ronald J. Holewinski, Yuchuan Wang, Catherine A. Foss, Steven S. An, Alessandra Baracca, Giancarlo Solaini, Charles G. Glabe, Martin G. Pomper, Jennifer E. Van Eyk, Gordon F. Tomaselli, Nazareno Paolocci, Giulio Agnetti JOURNAL: Circ Res. 2018 May 11;122(10):e75-e83. doi: 10.1161/CIRCRESAHA.117.312082. Epub 2018 Feb 26. Abstract RATIONALE: Disrupted(...)
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Posted by | Article of the WeekARTICLE: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 AUTHORS: Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Roman Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark M. Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L. J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.(...)
How to Incorporate Quality Improvement and Patient Safety Projects in Your Training
Posted by | Article of the WeekARTICLE: How to Incorporate Quality Improvement and Patient Safety Projects in Your Training AUTHORS: Shazia Mehmood Siddique, Gyanprakash Ketwaroo, Carolyn Newberry, Simon Mathews, Vandana Khungar, Shivan J. Mehta JOURNAL: Gastroenterology. 2018 May;154(6):1564-1568. doi: 10.1053/j.gastro.2018.03.044. Epub 2018 Mar 28. Abstract Engaging physicians in quality improvement (QI) and patient safety (PS) efforts has become increasingly central to creating(...)
The Key Role of Epigenetics in Human Disease Prevention and Mitigation
Posted by | Article of the WeekARTICLE: The Key Role of Epigenetics in Human Disease Prevention and Mitigation AUTHOR: Andrew P. Feinberg JOURNAL: N Engl J Med. 2018 Apr 5;378(14):1323-1334. doi: 10.1056/NEJMra1402513. The epigenome consists of nuclear information, heritable during cell division, that controls development, tissue differentiation, and cellular responsiveness. Epigenetic information is controlled by genome sequence, environmental exposure, and stochasticity, or random chance. As(...)
The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study
Posted by | Article of the WeekARTICLE: The Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States: A National Registry Study AUTHORS: Christine M. Durand, Mary G. Bowring, Alvin G. Thomas, Lauren M. Kucirka, Allan B. Massie, Andrew Cameron, Niraj M. Desai, Mark Sulkowski, Dorry L. Segev JOURNAL: Ann Intern Med. 2018 Apr 17; DOI: 10.7326/M17-2451 Abstract Background: The epidemic of drug(...)
Affordability and availability of off-patent drugs in the United States—the case for importing from abroad: observational study
Posted by | Article of the WeekARTICLE: Affordability and availability of off-patent drugs in the United States—the case for importing from abroad: observational study AUTHORS: Ravi Gupta, Thomas J Bollyky, Matthew Cohen, Joseph S Ross, Aaron S Kesselheim JOURNAL: BMJ. 2018 Mar 19;360:k831. doi: 10.1136/bmj.k831. Abstract OBJECTIVES: To evaluate whether off-patent prescription drugs at risk of sudden price increases or shortages in the United States are available from(...)
Germline mutations in the alternative pathway of complement predispose to HELLP syndrome
Posted by | Article of the WeekARTICLE: Germline mutations in the alternative pathway of complement predispose to HELLP syndrome AUTHORS: Arthur J. Vaught, Evan M. Braunstein, Jagar Jasem, Xuan Yuan, Igor Makhlin, Solange Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, Karin Blakemore, C. John Sperati and Robert A. Brodsky JOURNAL: JCI Insight. 2018 Mar 22;3(6). pii: 99128. doi: 10.1172/jci.insight.99128. [Epub ahead of print] Abstract BACKGROUND: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant(...)