ARTICLE: Germline mutations in the alternative pathway of complement predispose to HELLP syndrome AUTHORS: Arthur J. Vaught, Evan M. Braunstein, Jagar Jasem, Xuan Yuan, Igor Makhlin, Solange Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, Karin Blakemore, C. John Sperati and Robert A. Brodsky JOURNAL: JCI Insight. 2018 Mar 22;3(6). pii: 99128. doi: 10.1172/jci.insight.99128. [Epub ahead of print] Abstract BACKGROUND: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant(...)
Article of the Week
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Posted by | Article of the WeekARTICLE: Detection and localization of surgically resectable cancers with a multi-analyte blood test AUTHORS: Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph H. Hruban, Christopher L. Wolfgang, Michael G. Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P. Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne(...)
Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension
Posted by | Article of the WeekARTICLE: Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension AUTHORS: Valentina Mercurio, Monica Mukherjee, Ryan J. Tedford, Roham T. Zamanian, Rubina M. Khair, Takahiro Sato, Omar A. Minai, Fernando Torres, Reda E. Girgis, Kelly Chin, Rachel Damico, Todd M. Kolb, Stephen C. Mathai and Paul M. Hassoun JOURNAL: Am J Respir Crit Care Med. 2018 Feb 1;197(3):388-391. doi: 10.1164/rccm.201704-0789LE. To the Editor: Scleroderma-associated pulmonary arterial hypertension (SSc-PAH) is characterized by poor survival,(...)
Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension
Posted by | Article of the WeekARTICLE: Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension AUTHORS: Steven Hsu, Kristen M. Kokkonen-Simon, Jonathan A. Kirk, Todd M. Kolb, Rachel L. Damico, Stephen C. Mathai, Monica Mukherjee, Ami A. Shah, Fredrick M. Wigley, Kenneth B. Margulies, Paul M. Hassoun, Marc K. Halushka, Ryan J. Tedford, David A Kass JOURNAL: Circulation. 2018 Jan 19. pii: CIRCULATIONAHA.117.033147. doi: 10.1161/CIRCULATIONAHA.117.033147. [Epub ahead of(...)
Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg
Posted by | Article of the WeekARTICLE: Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg AUTHORS: Jason M Elinoff, Richa Agarwal, Christopher F Barnett, Raymond L Benza, Michael J Cuttica, Ahmed M. Gharib, Michael P Gray, Paul M Hassoun, Anna R Hemnes, Marc Humbert, Todd M Kolb, Tim Lahm, Jane A Leopold, Stephen C Mathai, Vallerie V McLaughlin, Ioana R Preston, Erika B Rosenzweig, Oksana A Shlobin, Virginia D Steen, Roham T Zamanian and Michael A. Solomon JOURNAL: Am J Respir Crit Care Med. 2018 Feb(...)
Association between Household Air Pollution Exposure and Chronic Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-Income Country Settings
Posted by | Article of the WeekARTICLE: Association between Household Air Pollution Exposure and Chronic Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-Income Country Settings AUTHORS: Trishul Siddharthan, Matthew R. Grigsby, Dina Goodman, Muhammad Chowdhury, Adolfo Rubinstein, Vilma Irazola, Laura Gutierrez, J. Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert Jones, Frederick van Gemert, Robert A. Wise, and William Checkley JOURNAL: Am J Respir Crit Care Med. 2018 Mar 1;197(5):611-620. doi: 10.1164/rccm.201709-1861OC. Abstract RATIONALE:(...)
Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine
Posted by | Article of the WeekThe educational outcomes from the iCOMPARE trial were published last week in the New England Journal of Medicine. iCOMPARE tested flexibility in duty hour policies in internal medicine residency. Sixty-three programs were randomized to 2011 rules or more flexible rules that had no limits in continuous hours of work and no mandatory minimums for time(...)
Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
Posted by | Article of the WeekARTICLE: Long-acting injectable atovaquone nanomedicines for malaria prophylaxis AUTHORS: Rahul P. Bakshi, Lee M. Tatham, Alison C. Savage, Abhai K. Tripathi, Godfree Mlambo, Matthew M. Ippolito, Elizabeth Nenortas, Steve P. Rannard, Andrew Owen and Theresa A. Shapiro JOURNAL: Nat Commun. 2018 Jan 22;9(1):315. doi: 10.1038/s41467-017-02603-z. Abstract Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles(...)
Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer
Posted by | Article of the WeekARTICLE: Patient Age–Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer AUTHORS: Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K. Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J. O’Neill, Mark S. Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, and Mingzhao Xing JOURNAL: J Clin Oncol. 2018 Feb 10;36(5):438-445. doi: 10.1200/JCO.2017.74.5497. Epub 2017 Dec 14. Abstract Purpose(...)
Single-board hematology fellowship track: a 10-year institutional experience
Posted by | Article of the WeekARTICLE: Single-board hematology fellowship track: a 10-year institutional experience AUTHORS: Rakhi P. Naik, Kristen Marrone, Samuel Merrill, Ross Donehower and Robert Brodsky JOURNAL: Blood. 2018 Jan 25;131(4):462-464. doi: 10.1182/blood-2017-11-816207. Epub 2017 Dec 11. TO THE EDITOR: In the United States, internal medicine subspecialty training is dictated primarily by the Accreditation Council for Graduate Medical Education (ACGME), which sets standards for clinical and education program requirements for recognized fellowships. For adult hematology and(...)