ARTICLE: Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review AUTHORS: Rakhi P. Naik, Kim Smith-Whitley, Kathryn L. Hassell, Nkeiruka I. Umeh, Mariane de Montalembert, Puneet Sahota, Carlton Haywood Jr., Jean Jenkins, Michele A. Lloyd-Puryear, Clinton H. Joiner, Vence L. Bonham, Gregory J. Kato JOURNAL: Ann Intern Med. 2018 Oct 30. doi: 10.7326/M18-1161. [Epub ahead of(...)
Article of the Week
How Community Health Workers Can Affect Health Care
Posted by | Article of the WeekARTICLE: How Community Health Workers Can Affect Health Care AUTHORS: Ryan Graddy and Michael Fingerhood JOURNAL: JAMA Intern Med. 2018 Oct 22. doi:10.1001/jamainternmed.2018.4626. Interventions that seek to improve patient health among marginalized populations by addressing the social determinants of health have received increasing emphasis in recent years. The expanding understanding that health is deeply affected by nonmedical aspects(...)
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability
Posted by | Article of the WeekARTICLE: Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability AUTHORS: Andrew J. King1, Matthew Siegel, Ying He, Baoming Nie, Ji Wang, Samantha Koo-McCoy, Natali A. Minassian, Qumber Jafri, Deng Pan, Jill Kohler, Padmapriya Kumaraswamy, Kenji Kozuka, Jason G. Lewis, Dean Dragoli, David P. Rosenbaum, Debbie O’Neill, Allein Plain,(...)
Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline
Posted by | Article of the WeekARTICLE: Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline AUTHORS: David J. Feller-Kopman, Chakravarthy B. Reddy, Malcolm M. DeCamp, Rebecca L. Diekemper, Michael K. Gould, Travis Henry, Narayan P. Iyer, Y. C. Gary Lee, Sandra Z. Lewis, Nick A. Maskell, Najib M. Rahman, Daniel H. Sterman, Momen M. Wahidi, and Alex A. Balekian JOURNAL: Am J Respir Crit Care Med. 2018 Oct 1;198(7):839-849. doi: 10.1164/rccm.201807-1415ST. Abstract BACKGROUND: This Guideline, a collaborative effort from the American Thoracic(...)
Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity
Posted by | Article of the WeekARTICLE: Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity AUTHORS: Pardeep Kumar, F. Matthew Kuhlmann, Subhra Chakraborty, A. Louis Bourgeois, Jennifer Foulke-Abel, Brunda Tumala, Tim J. Vickers, David A. Sack, Barbara DeNearing, Clayton D. Harro, W. Shea Wright, Jeffrey C. Gildersleeve, Matthew A. Ciorba, Srikanth Santhanam, Chad K. Porter, Ramiro L. Gutierrez, Michael G.(...)
BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer
Posted by | Article of the WeekARTICLE: BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer AUTHORS: Fei Wang, Shihua Zhao, Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu,Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K. Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J. O’Neill, Mark S. Sywak,Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, Yangang Wang, and Mingzhao Xing JOURNAL: J Clin Oncol. 2018 Sep 20;36(27):2787-2795. doi: 10.1200/JCO.2018.78.5097. Epub(...)
Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia
Posted by | Article of the WeekARTICLE: Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia AUTHORS: Adityo Prakosa, Hermenegild J. Arevalo, Dongdong Deng, Patrick M. Boyle, Plamen P. Nikolov, Hiroshi Ashikaga, Joshua J. E. Blauer, Elyar Ghafoori, Carolyn J. Park, Robert C. Blake III, Frederick T. Han, Rob S. MacLeod, Henry R. Halperin, David J. Callans, Ravi Ranjan, Jonathan Chrispin, Saman Nazarian and Natalia A. Trayanova JOURNAL: Nat Biomed Eng. 2018 Sep 3. Doi: 10.1038/s41551-018-0282-2 Abstract(...)
Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance
Posted by | Article of the WeekARTICLE: Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance AUTHORS: Marcia Irene Canto, Jose Alejandro Almario, Richard D. Schulick, Charles J. Yeo, Alison Klein, Amanda Blackford, Eun Ji Shin, Abanti Sanyal, Gayane Yenokyan, Anne Marie Lennon, Ihab R. Kamel, Elliot K. Fishman, Christopher Wolfgang, Matthew Weiss, Ralph H. Hruban and Michael Goggins JOURNAL: Gastroenterology. 2018 Sep;155(3):740-751.e2. doi: 10.1053/j.gastro.2018.05.035. Epub 2018 May 24.(...)
Precardiac organoids form two heart fields via Bmp/Wnt signaling
Posted by | Article of the WeekARTICLE: Precardiac organoids form two heart fields via Bmp/Wnt signaling AUTHORS: Peter Andersen, Emmanouil Tampakakis, Dennisse V. Jimenez, Suraj Kannan, Matthew Miyamoto, Hye Kyung Shin, Amir Saberi, Sean Murphy, Edrick Sulistio, Stephen P. Chelko and Chulan Kwon JOURNAL: Nat Commun. 2018 Aug 7;9(1):3140. doi: 10.1038/s41467-018-05604-8. Abstract The discovery of the first heart field (FHF) and the second heart field (SHF) led us to understand how cardiac(...)
CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans
Posted by | Article of the WeekARTICLE: CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans AUTHORS: Ramy El-Diwany, Mary Soliman, Sho Sugawara, Florian Breitwieser, Alyza Skaist, Candelaria Coggiano, Neel Sangal, Michael Chattergoon, Justin R. Bailey, Robert F. Siliciano, Joel N. Blankson, Stuart C. Ray, Sarah J. Wheelan, David L. Thomas and Ashwin Balagopal JOURNAL: Sci Adv. 2018 Aug 1;4(8):eaat0843. doi: 10.1126/sciadv.aat0843. eCollection 2018 Aug. Abstract Type 1 interferons (IFN) are critical for host control(...)