ARTICLE: Eliminating Creatine Kinase-Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement AUTHORS: Matthew D. Alvin, Allan S. Jaffe, Roy C. Ziegelstein, Jeffrey C. Trost JOURNAL: JAMA Intern Med. 2017 Oct 1;177(10):1508-1512. doi: 10.1001/jamainternmed.2017.3597. Abstract Cardiac biomarker testing is estimated to occur in nearly 30 million emergency department visits nationwide each year in the United States. The American College of Cardiology/European Society of Cardiology indicate that cardiac troponin is the biomarker(...)
Article of the Week
Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer
Posted by | Article of the WeekARTICLE: Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer AUTHORS: Rengyun Liu, Tao Zhang, Guangwu Zhu, Mingzhao Xing JOURNAL: Nat Commun. 2018 Feb 8;9(1):579. doi: 10.1038/s41467-018-03033-1. Abstract The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are widely found to be a robust genetic background promoting human cancer aggressiveness, but the mechanism is unclear. Here, we demonstrate that the BRAF V600E/MAP kinase pathwayphosphorylates and(...)
The Colonic Mucosa of Patients with Familial Adenomatous Polyposis Harbor Biofilms Containing Tumorigenic Bacteria
Posted by | Article of the WeekARTICLE: The Colonic Mucosa of Patients with Familial Adenomatous Polyposis Harbor Biofilms Containing Tumorigenic Bacteria AUTHORS: Christine M. Dejea, Payam Fathi, John M. Craig, Annemarie Boleij, Rahwa Taddese, Abby L. Geis, Xinqun Wu, Christina E. DeStefano Shields, Elizabeth M. Hechenbleikner, David L. Huso, Robert A. Anders, Francis M. Giardiello, Elizabeth C. Wick, Hao Wang, Shaoguang Wu,(...)
Fasting vs Non-Fasting and Low-Density Lipoprotein-Cholesterol Accuracy
Posted by | Article of the WeekARTICLE: Fasting vs Non-Fasting and Low-Density Lipoprotein-Cholesterol Accuracy AUTHORS: Vasanth Sathiyakumar, Jihwan Park, Asieh Golozar, Mariana Lazo, Renato Quispe, Eliseo Guallar, Roger S. Blumenthal, Steven R. Jones, Seth S. Martin JOURNAL: Circulation. 2017 Oct 16; 117.03067. Abstract Background: Recent recommendations favoring non-fasting lipid assessment may impact low-density lipoprotein-cholesterol (LDL-C) estimation. The novel method of LDL-C estimation (LDL-CN) uses a flexible approach to derive patient-specific(...)
Research Priorities in Pathophysiology for Sleep-disordered Breathing in Patients with Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Research Statement
Posted by | Article of the WeekARTICLE: Research Priorities in Pathophysiology for Sleep-disordered Breathing in Patients with Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Research Statement AUTHORS: Atul Malhotra, Alan R. Schwartz, Hartmut Schneider, Robert L. Owens, Pamela DeYoung, MeiLan K. Han, Jadwiga A. Wedzicha, Nadia N. Hansel, Michelle R. Zeidler, Kevin C. Wilson, and M. Safwan Badr; on behalf of the ATS Assembly on Sleep and Respiratory(...)
Six-year changes in physical activity and the risk of incident heart failure: the atherosclerosis risk in communities (ARIC) study
Posted by | Article of the WeekARTICLE: Six-year changes in physical activity and the risk of incident heart failure: the atherosclerosis risk in communities (ARIC) study AUTHORS: Roberta Florido, Lucia Kwak, Mariana Lazo, Vijay Nambi, Haitham M. Ahmed, Sheila M. Hegde, Gary Gerstenblith, Roger S. Blumenthal, Christie M. Ballantyne, Elizabeth Selvin, Aaron R. Folsom, Josef Coresh, Chiadi E. Ndumele JOURNAL: Circulation. 2018 Jan 31. pii: CIRCULATIONAHA.117.030226. doi: 10.1161/CIRCULATIONAHA.117.030226. [Epub ahead of print] Abstract Background: Higher physical activity(...)
Shedding New Light on the Magnitude of Thrombosis Risk in Patients With Myeloproliferative Neoplasms
Posted by | Article of the WeekARTICLE: Shedding New Light on the Magnitude of Thrombosis Risk in Patients With Myeloproliferative Neoplasms AUTHORS: Alison R. Moliterno and Elizabeth V. Ratchford JOURNAL: Ann Intern Med. 2018 Jan 16. doi: 10.7326/M17-3153. [Epub ahead of print] Myeloproliferative diseases were first described by William Dameshek in 1951. In 2008, the World Health Organization established a new classification(...)
BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment
Posted by | Article of the WeekARTICLE: BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment AUTHORS: Yueye Huang, Shen Qu, Guangwu Zhu, Fei Wang, Rengyun Liu, Xiaopei Shen, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K. Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban,(...)
Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices
Posted by | Article of the WeekARTICLE: Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices AUTHORS: Saman Nazarian, Rozann Hansford, Amir A. Rahsepar, Valeria Weltin, Diana McVeigh, Esra Gucuk Ipek, Alan Kwan, Ronald D. Berger, Hugh Calkins, Albert C. Lardo, Michael A. Kraut, Ihab R. Kamel, Stefan L. Zimmerman and Henry R. Halperin JOURNAL: N Engl J Med. 2017 Dec(...)
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers
Posted by | Article of the WeekARTICLE: Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers AUTHORS: Joshua D. Cohen, Ammar A. Javed, Christopher Thoburn, Fay Wong, Jeanne Tie, Peter Gibbs, Max Schmidt, Michele T. Yip-Schneider, Peter J. Allen, Mark Schattner, Randall E. Brand, Aatur D. Singhi, Gloria M. Petersen, Seung-Mo Hong, Song Cheol Kim, Massimo Falconi, Claudio Doglioni, Matthew J. Weiss, Nita Ahuja, Jin He, Martin A. Makary, Anirban Maitra, Samir M. Hanash, Marco Dal Molin, Yuxuan(...)