ARTICLE: Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers AUTHORS: Joshua D. Cohen, Ammar A. Javed, Christopher Thoburn, Fay Wong, Jeanne Tie, Peter Gibbs, Max Schmidt, Michele T. Yip-Schneider, Peter J. Allen, Mark Schattner, Randall E. Brand, Aatur D. Singhi, Gloria M. Petersen, Seung-Mo Hong, Song Cheol Kim, Massimo Falconi, Claudio Doglioni, Matthew J. Weiss, Nita Ahuja, Jin He, Martin A. Makary, Anirban Maitra, Samir M. Hanash, Marco Dal Molin, Yuxuan(...)
Article of the Week
Going from A to Z
Posted by | Article of the WeekARTICLE: Going from A to Z AUTHORS: Deepak Atri, David Furfaro, Gurpreet Dhaliwal, Kenneth R. Feingold and Reza Manesh JOURNAL: N Engl J Med. 2018 Jan 4;378(1):73-79. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the(...)
Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014
Posted by | Article of the WeekARTICLE: Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014 AUTHORS: Tanjala S. Purnell, Xun Luo, Lisa A. Cooper, Allan B. Massie, Lauren M. Kucirka, Macey L. Henderson, Elisa J. Gordon, Deidra C. Crews, L. Ebony Boulware, Dorry L. Segev JOURNAL: JAMA. 2018 Jan 2;319(1):49-61. doi: 10.1001/jama.2017.19152. Abstract IMPORTANCE: Over the past 2 decades, there has been increased attention and effort to reduce disparities in live donor kidneytransplantation (LDKT) for black, Hispanic, and(...)
Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independentmechanisms
Posted by | Article of the WeekARTICLE: Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independentmechanisms AUTHORS: Madeleine C. Mankowski, Valerie J. Kinchen, Lisa N. Wasilewski, Andrew I. Flyak, Stuart C. Ray, James E. Crowe, Jr. and Justin R. Bailey JOURNAL: Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E82-E91. doi: 10.1073/pnas.1718441115. Epub 2017 Dec 18. Abstract There is an urgent need for a vaccine to combat the hepatitis C(...)
HIV Prevention Efforts and Incidence of HIV in Uganda
Posted by | Article of the WeekARTICLE: HIV Prevention Efforts and Incidence of HIV in Uganda AUTHORS: M. Kate Grabowski, David M. Serwadda, Ronald H. Gray, Gertrude Nakigozi, Godfrey Kigozi, Joseph Kagaayi, Robert Ssekubugu, Fred Nalugoda, Justin Lessler, Thomas Lutalo, Ronald M. Galiwango, Fred Makumbi, Xiangrong Kong, Donna Kabatesi, Stella T. Alamo, Steven Wiersma, Nelson K. Sewankambo, Aaron A.R. Tobian, Oliver(...)
Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure
Posted by | Article of the WeekARTICLE: Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure AUTHORS: Stephen P. Juraschek, Edgar R. Miller III, Connie M. Weaver, Lawrence J. Appel JOURNAL: J Am Coll Cardiol. 2017 Dec 12;70(23):2841-2848. doi: 10.1016/j.jacc.2017.10.011. Epub 2017 Nov 12. Abstract BACKGROUND: Both sodium reduction and the DASH (Dietary Approaches to Stop Hypertension) diet, a diet rich in fruits, vegetables, and low-fat dairy products, and reduced in saturated fat and cholesterol, lower blood pressure. The separate and(...)
Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies
Posted by | Article of the WeekARTICLE: Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies AUTHORS: Abdulla A. Damluji, Daniel W. Nelson, Marco Valgimigli, Stephan Windecker, Robert A. Byrne, Fernando Cohen, Tejas Patel, Emmanouil S. Brilakis, Subhash Banerjee, Jorge Mayol, Warren J. Cantor, Carlos E. Alfonso, Sunil V. Rao, Mauro Moscucci and Mauricio G. Cohen JOURNAL: JACC Cardiovasc Interv. 2017 Nov 27;10(22):2269-2279. doi: 10.1016/j.jcin.2017.08.035. Abstract OBJECTIVES: The aim of this study was to examine the current practice and(...)
Treatment concentration of high-sensitivity C-reactive protein
Posted by | Article of the WeekARTICLE: Treatment concentration of high-sensitivity C-reactive protein AUTHORS: Erin D. Michos, Roger S. Blumenthal JOURNAL: Lancet. 2017 Nov 13. pii: S0140-6736(17)32865-9. doi: 10.1016/S0140-6736(17)32865-9. [Epub ahead of print] The landmark CANTOS trial evaluated the use of canakinumab, a monoclonal antibodytargeting interleukin 1β, in 10 061 patients with previous myocardial infarction who had high-sensitivity C-reactive protein (hsCRP) concentrations of 2 mg/L or higher.1 Interleukin 1β has multiple(...)
A tripartite complex of suPAR, APOL1 risk variants and integrin on podocytes mediates chronic kidney disease
Posted by | Article of the WeekARTICLE: A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease AUTHORS: Salim S Hayek, Kwi Hye Koh, Morgan E Grams, Changli Wei, Yi-An Ko, Jing Li, Beata Samelko, Hyun Lee, Ranadheer R Dande, Ha Won Lee, Eunsil Hahm, Vasil Peev, Melissa Tracy, Nicholas J Tardi, Vineet Gupta(...)
Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study
Posted by | Article of the WeekARTICLE: Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition: A Cross-sectional Study AUTHORS: Elizabeth Selvin, Dan Wang, Alexandra K. Lee, Richard M. Bergenstal, Josef Coresh JOURNAL: Ann Intern Med. 2017 Oct 24. doi: 10.7326/M17-1272. [Epub ahead of print] Abstract Background: A common belief is that one quarter to one third of all(...)