Article of the Week

Myeloproliferative Neoplasms

Myeloproliferative Neoplasms

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ARTICLE: Myeloproliferative Neoplasms AUTHORS: Jerry L. Spivak JOURNAL: N Engl J Med. 2017 Jun 1; 376:2168-2181. doi: 10.1056/NEJMra1406186 The myeloproliferative neoplasms — polycythemia vera, essential thrombocytosis, and primary myelofibrosis — are unique hematopoietic stem-cell disorders that share mutations that constitutively activate the physiologic signal-transduction pathways responsible for hematopoiesis. Consequently, these disorders engage in phenotypic mimicry(...)

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Older Adults’ Views and Communication Preferences About Cancer Screening Cessation

Older Adults’ Views and Communication Preferences About Cancer Screening Cessation

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ARTICLE: Older Adults' Views and Communication Preferences About Cancer Screening Cessation AUTHORS: Nancy L. Schoenborn, Kimberley Lee, Craig E. Pollack, Karen Armacost, Sydney M. Dy, John F. P. Bridges, Qian-Li Xue, Antonio C. Wolff, Cynthia Boyd JOURNAL: JAMA Intern Med. 2017 Jun 12. doi: 10.1001/jamainternmed.2017.1778. [Epub ahead of print] Abstract IMPORTANCE: Older adults with limited life expectancy are frequently screened for cancer even though it exposes them to risks of screeningwith minimal benefit. Patient preferences may be an important contributor to continued screening. OBJECTIVE: To examine older adults' views on the(...)

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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

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ARTICLE: Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes AUTHORS: Annika S. Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A. Nenonen, Yunzhao Tang, Jed W. Fahey, Jonathan M. J. Derry, Claes B. Wollheim, Nils Wierup, Morey W. Haymond, Stephen H. Friend, Hindrik Mulder and Anders H. Rosengren JOURNAL: Sci Transl Med. 2017 Jun 14;9(394). pii: eaah4477. doi: 10.1126/scitranslmed.aah4477. Abstract A potentially useful(...)

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Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs

Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs

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ARTICLE: Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs AUTHORS: Abraham J. Kandathil, Florian P. Breitwieser, Jaiprasath Sachithanandham, Matthew Robinson, Shruti H. Mehta, Winston Timp, Steven L. Salzberg, David L. Thomas, Ashwin Balagopal JOURNAL: Ann Intern Med. 2017 Jun 6. doi: 10.7326/M17-0085. [Epub ahead of print] Abstract Background: Next-generation metagenomic sequencing (NGMS)(...)

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Looking Beyond the Tip of a Tusk: Balancing the Evidence in Prognosis-related Communication

Looking Beyond the Tip of a Tusk: Balancing the Evidence in Prognosis-related Communication

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ARTICLE: Looking Beyond the Tip of a Tusk: Balancing the Evidence in Prognosis-related Communication. AUTHORS: Rebecca A Aslakson and Mary Catherine Beach JOURNAL: Am J Respir Crit Care Med. 2017 May 16. doi: 10.1164/rccm.201704-0851ED. [Epub ahead of print] Evidence supports a poor prognosis for patients with chronic critical illness; 30- 40% die prior to hospital discharge, and another(...)

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A microbiome variable in the HIV-prevention equation

A microbiome variable in the HIV-prevention equation

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ARTICLE: A microbiome variable in the HIV-prevention equation AUTHORS: Susan Tuddenham and Khalil G. Ghanem JOURNAL: Science. 2017 Jun 2;356(6341):907-908. doi: 10.1126/science.aan6103. Summary The healthy vaginal microbiota is typically characterized by the predominance of Lactobacillus species (including L. crispatus, L. jensenii, L. gasseri, and L. iners). These bacteria are thought to protect against pathogens through a variety of mechanisms, including(...)

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Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review

Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review

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ARTICLE: Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review AUTHORS: Oluwaseun Falade-Nwulia, Catalina Suarez-Cuervo, David R. Nelson, Michael W. Fried, Jodi B. Segal, Mark S. Sulkowski JOURNAL: Ann Intern Med. 2017 May 2;166(9):637-648. doi: 10.7326/M16-2575. Epub 2017 Mar 21. Abstract BACKGROUND: Rapid improvements in hepatitis C virus (HCV) therapy have led to(...)

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Emergency Department Query for Patient-Centered Approaches to Sexual Orientation and Gender Identity: The EQUALITY Study

Emergency Department Query for Patient-Centered Approaches to Sexual Orientation and Gender Identity: The EQUALITY Study

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ARTICLE: Emergency Department Query for Patient-Centered Approaches to Sexual Orientation and Gender Identity: The EQUALITY Study AUTHORS: Adil H. Haider, Eric B. Schneider, Lisa M. Kodadek, Rachel R. Adler, Anju Ranjit, Maya Torain, Ryan Y. Shields, Claire Snyder, Jeremiah D. Schuur, Laura Vail, Danielle German, Susan Peterson, Brandyn D. Lau JOURNAL: JAMA Intern Med. 2017 Jun 1;177(6):819-828. doi: 10.1001/jamainternmed.2017.0906. Abstract IMPORTANCE: The Institute of Medicine and The Joint Commission recommend routine documentation of patients'(...)

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A Year at the Bedside With Osler

A Year at the Bedside With Osler

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ARTICLE: A Year at the Bedside With Osler AUTHORS: Jason Liebowitz JOURNAL: JAMA Intern Med. 2017 May 1. doi: 10.1001/jamainternmed.2017.1080. [Epub ahead of print] He who studies medicine without books sails an uncharted sea, but he who studies medicine without patients does not go to sea at all. Sir William Osler1 Ask any resident, and he or(...)

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Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis

Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis

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ARTICLE: Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis. AUTHORS: Lisa M. Wilson, Casey M. Rebholz, Ermias Jirru, Marisa Chi Liu, Allen Zhang, Jessica Gayleard, Karen A. Robinson JOURNAL: Ann Intern Med. 2017 May 2;166(9):649-658. doi: 10.7326/M16-2752. Epub 2017 Apr 11. Abstract BACKGROUND: Complications of chronic kidney(...)

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