ARTICLE: Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA AUTHORS: Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E. Ndumele, Eliseo Guallar, Kavita Sharma, Sanjiv J. Shah, David A. Kass, Ron C. Hoogeveen, Joao A. Lima, Susan R. Heckbert, Christopher R. deFilippi, Wendy S. Post and Erin D. Michos JOURNAL: […]
Article of the Week
Ending the Human Immunodeficiency Virus Epidemic: Towards an Evidence-Based Approach
Posted by | Article of the WeekARTICLE: Ending the Human Immunodeficiency Virus Epidemic: Towards an Evidence-Based Approach AUTHORS: Anthony Fojo and David Dowdy JOURNAL: Clin Infect Dis. 2019 Nov 27;69(12):2199-2200. doi: 10.1093/cid/ciz1018. Abstract The newly announced Ending the HIV Epidemic (EtHE) initiative aims to reduce the human immunodeficiency virus (HIV) incidence in the United States by 90% within 10 years. The initiative […]
Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV
Posted by | Article of the WeekARTICLE: Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV AUTHORS: Robert C Bollinger, Chloe L Thio, Mark S Sulkowski, Jane McKenzie-White, David L Thomas and Charles Flexner JOURNAL: Lancet HIV. 2019 Dec 20. pii: S2352-3018(19)30342-X. doi: 10.1016/S2352-3018(19)30342-X. [Epub ahead of print] Abstract The first long-acting formulations of HIV drugs are undergoing regulatory review for use […]
Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association
Posted by | Article of the WeekARTICLE: Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association AUTHORS: Abdulla A. Damluji, Daniel E. Forman, Sean van Diepen, Karen P. Alexander, Robert L. Page II, Scott L. Hummel, Venu Menon, Jason N. Katz, Nancy M. Albert, Jonathan Afilalo, Mauricio G. Cohen JOURNAL: Circulation. 2019 Dec 9:CIR0000000000000741. doi: 10.1161/CIR.0000000000000741. [Epub ahead of print] Abstract Longevity is increasing, and more adults are living to […]
Association Between Treatment by Fraud and Abuse Perpetrators and Health Outcomes Among Medicare Beneficiaries
Posted by | Article of the WeekARTICLE: Association Between Treatment by Fraud and Abuse Perpetrators and Health Outcomes Among Medicare Beneficiaries AUTHORS: Lauren Hersch Nicholas, Caroline Hanson, Jodi B. Segal, Matthew D. Eisenberg JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4771. [Epub ahead of print] Abstract IMPORTANCE: Fraud and abuse contribute to unnecessary spending in the Medicare program, and federal agencies have prioritized fund recovery and the exclusion of health care […]
Association of Long-term Ambient Ozone Exposure with Respiratory Morbidity in Smokers
Posted by | Article of the WeekARTICLE: Association of Long-term Ambient Ozone Exposure with Respiratory Morbidity in Smokers AUTHORS: Laura M. Paulin, Amanda J. Gassett, Neil E. Alexis, Kipruto Kirwa, Richard E. Kanner, Stephen Peters, Jerry A. Krishnan, Robert Paine III, Mark Dransfield, Prescott G. Woodruff, Christopher B. Cooper, R. Graham Barr, Alejandro P. Comellas, Cheryl S. Pirozzi, MeiLan Han, Eric A. Hoffman, Fernando J. Martinez, Han Woo, Roger D. Peng, Ashraf Fawzy, Nirupama Putcha, Patrick N. Breysse, Joel D. Kaufman, Nadia N. Hansel, for SPIROMICS investigators JOURNAL: JAMA Intern Med. 2019 Dec 9. […]
Time From Submission of Johns Hopkins University Trial Results to Posting on ClinicalTrials.gov
Posted by | Article of the WeekARTICLE: Time From Submission of Johns Hopkins University Trial Results to Posting on ClinicalTrials.gov AUTHORS: Anthony Keyes, Evan Mayo-Wilson, Nidhi Atri, Aliya Lalji, Prince S. Nuamah, Oswald Tetteh and Daniel E. Ford JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4710. [Epub ahead of print] The US Food and Drug Administration Amendments Act of 2007 (FDAAA)1 requires that applicable clinical trials (ACTs) […]
Confronting Bias and Discrimination in Health Care–When Silence Is Not Golden
Posted by | Article of the WeekARTICLE: Confronting Bias and Discrimination in Health Care-When Silence Is Not Golden AUTHORS: Lisa Cooper, Mary Catherine Beach and David Williams JOURNAL: JAMA Intern Med. 2019 Oct 28. doi: 10.1001/jamainternmed.2019.4100. [Epub ahead of print] In this issue of JAMA Internal Medicine, Wheeler et al1 report results from a novel qualitative study in which the investigators examined how physicians and trainees perceive, react, and respond to incidents of […]
Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity
Posted by | Article of the WeekARTICLE: Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity AUTHORS: Ling Li, Hildur Knutsdottir, Ken Hui, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Joel S. Bader and Florin M. Selaru JOURNAL: JCI Insight. 2019 Jan 24;4(2). […]
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Posted by | Article of the WeekARTICLE: A quantitative approach for measuring the reservoir of latent HIV-1 proviruses AUTHORS: Katherine M. Bruner, Zheng Wang, Francesco R. Simonetti, Alexandra M. Bender, Kyungyoon J. Kwon, Srona Sengupta, Emily J. Fray, Subul A. Beg, Annukka A. R. Antar, Katharine M. Jenike, Lynn N. Bertagnolli, Adam A. Capoferri, Joshua T. Kufera, Andrew Timmons, Christopher Nobles, John Gregg, Nikolas Wada, Ya-Chi Ho, Hao Zhang, Joseph B. Margolick, Joel N. Blankson, Steven G. Deeks, Frederic D. Bushman, Janet D. Siliciano, Gregory […]