ARTICLE: Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing AUTHORS: Kevin P. Eaton, Kathryn Levy, Christine Soong, Amit K. Pahwa, Christopher Petrilli, Justin B. Ziemba, Hyung J. Cho, Rodrigo Alban, Jaime F. Blanck, Andrew S. Parsons JOURNAL: JAMA Intern Med. 2017 Oct 16. doi: 10.1001/jamainternmed.2017.5152. [Epub ahead of print] Abstract Routine daily laboratory testing of hospitalized patients reflects a wasteful clinical practice that threatens the value of health care. Choosing Wisely initiatives from numerous professional societies have identified repetitive laboratory testing in the(...)

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ARTICLE: Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans AUTHORS: Joshua J. Joseph, Justin B. Echouffo-Tcheugui, Rita R. Kalyani, Hsin-Chieh Yeh, Alain G. Bertoni, Valery S. Effoe,  Ramon Casanova, Mario Sims, Wen-Chih Wu, Gary S. Wand, Adolfo Correa, Sherita H. Golden JOURNAL: JACC Heart Fail. 2017 Sep;5(9):642-651. doi: 10.1016/j.jchf.2017.05.012. Epub 2017 Aug 16. Abstract(...)

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ARTICLE: Is There Merit in Merit Aid? AUTHORS: Roy C. Ziegelstein, Charles G. Prober, Lloyd B. Minor, George Q. Daley, Paul B. Rothman, and Edward M. Hundert JOURNAL: N Engl J Med. 2017 Oct 25. doi: 10.1056/NEJMp1713146. [Epub ahead of print] In 2016, the average cost of attending medical school (including tuition and fees) in the(...)

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ARTICLE: Association of Mitochondrial DNA Copy Number With Cardiovascular Disease AUTHORS: Foram N. Ashar, Yiyi Zhang, Ryan J. Longchamps, John Lane, Anna Moes, Megan L. Grove, Josyf C. Mychaleckyj, Kent D. Taylor, Josef Coresh, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Eliseo Guallar, Dan E. Arking JOURNAL: JAMA Cardiol. 2017 Oct 11. doi: 10.1001/jamacardio.2017.3683. [Epub ahead of print] Abstract IMPORTANCE: Mitochondrial dysfunction is a core component of the aging process and may play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number (mtDNA-CN), which represents the number of mitochondria(...)

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ARTICLE: Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults AUTHORS: Stephen P. Juraschek, Natalie Daya, Andreea M. Rawlings, Lawrence J. Appel, Edgar R. Miller III, B. Gwen Windham, Michael E. Griswold, Gerardo Heiss, Elizabeth Selvin JOURNAL: JAMA Intern Med. 2017 Sep 1;177(9):1316-1323. doi: 10.1001/jamainternmed.2017.2937. Abstract IMPORTANCE: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after rising from supine to(...)

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ARTICLE: Delirium in Older Persons: Advances in Diagnosis and Treatment. AUTHORS: Esther S. Oh, Tamara G. Fong, Tammy T. Hshieh, Sharon K. Inouye JOURNAL: JAMA. 2017 Sep 26;318(12):1161-1174. doi: 10.1001/jama.2017.12067. Abstract IMPORTANCE: Delirium is defined as an acute disorder of attention and cognition. It is a common, serious, and often fatal condition among older patients. Although often underrecognized, delirium has serious adverse effects on the individual's function and quality of life, as well as broad societal(...)

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ARTICLE: A Research Agenda for Communication Between Health Care Professionals and Patients Living With Serious Illness. AUTHORS: James A. Tulsky, Mary Catherine Beach, Phyllis N. Butow, Susan E. Hickman, Jennifer W. Mack, R. Sean Morrison, Richard L. Street Jr, Rebecca L. Sudore, Douglas B. White, Kathryn I. Pollak JOURNAL: JAMA Intern Med. 2017 Sep 1;177(9):1361-1366. doi: 10.1001/jamainternmed.2017.2005. Abstract IMPORTANCE: Poor communication by health care professionals contributes to physical and(...)

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ARTICLE: Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy AUTHORS: Meera C. Viswanathan, William Schmidt, Michael J. Rynkiewicz, Karuna Agarwal, Jian Gao, Joseph Katz, William Lehman, Anthony Cammarato JOURNAL: Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070. Abstract Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which(...)

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ARTICLE: The Association of Sleep Duration and Quality with CKD Progression AUTHORS: Ana C. Ricardo, Kristen Knutson, Jinsong Chen, Lawrence J. Appel, Lydia Bazzano, Eunice Carmona-Powell, Janet Cohan,Manjula Kurella Tamura, Susan Steigerwalt, John Daryl Thornton,Matthew Weir, Nicolas F. Turek, Mahboob Rahman, Eve Van Cauter, James P. Lash, the Chronic Renal Insufficiency Cohort (CRIC) JOURNAL: J Am Soc Nephrol. 2017 Sep 14. pii: ASN.2016121288. doi: 10.1681/ASN.2016121288. [Epub ahead(...)

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ARTICLE: Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease. AUTHORS: Casey M. Rebholz, Elizabeth Selvin, Menglu Liang, Christie M. Ballantyne, Ron C. Hoogeveen, David Aguilar, John W. McEvoy, Morgan E. Grams, Josef Coresh JOURNAL: Kidney Int. 2017 Aug 30. pii: S0085-2538(17)30497-0. doi: 10.1016/j.kint.2017.06.028. [Epub ahead of print] Abstract Galectin-3 has been(...)

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