Medicine Matters

ARTICLE: Phase 2 Study of Danicopan in Paroxysmal Nocturnal Hemoglobinuria Patients with an Inadequate Response to Eculizumab AUTHORS: Austin Kulesekararaj, Antonio Maria Risitano, Jaroslaw P Maciejewski, Rosario Notaro, Peter J Browett, Jong Wook Lee, Mingjun Huang, Michael Geffner, Robert A Brodsky JOURNAL: Blood. 2021 Jul 27;blood.2021011388. doi: 10.1182/blood.2021011388. Online ahead of print. Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is characterised by uncontrolled terminal complement activation and […]

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ARTICLE: Race/Ethnicity and Prevalence of Aortic Stenosis by Echocardiography in the Multi-Ethnic Study of Atherosclerosis AUTHORS: Matthew J Czarny, Sanjiv J Shah, Seamus P Whelton, Michael J Blaha, Michael Y Tsai, Rimsky Denis, Alain Bertoni, Wendy S Post JOURNAL: J Am Coll Cardiol. 2021 Jul 13;78(2):195-197. doi: 10.1016/j.jacc.2021.04.078. Epub 2021 May 11. Although long present, racial/ethnic disparities in cardiovascular care are increasingly recognized. A study […]

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ARTICLE: Characteristics of Copayment Offsets for Prescription Drugs in the United States AUTHORS: Aditi P Sen, So-Yeon Kang, Emaan Rashidi, Devoja Ganguli, Gerard Anderson, G Caleb Alexander JOURNAL: JAMA Intern Med. 2021 Jun 1;181(6):758-764. doi: 10.1001/jamainternmed.2021.0733. Abstract Importance: Despite ongoing debate regarding the high prices that patients pay for prescription drugs, to our knowledge, little is known regarding the use of coupons, vouchers, […]

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ARTICLE: Recommendations for including or reviewing patient reported outcome endpoints in grant applications AUTHORS: Claire Snyder, Alexandra Gilbert, David Moher, Derek Kyte, Ellie Daniels, Madeleine King, Melanie Calvert, Ronald C Chen, Michael Brundage, PROTEUS consortium JOURNAL: BMJ. 2021 Jun 30;373:n1367. doi: 10.1136/bmj.n1367. Abstract Patient reported outcomes are increasingly included in research studies to provide the patient perspective. Grant applicants and grant reviewers require guidance on the […]

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ARTICLE: Trends in Diabetes Treatment and Control in U.S. Adults, 1999-2018 AUTHORS: Michael Fang, Dan Wang, Josef Coresh, Elizabeth Selvin JOURNAL: N Engl J Med. 2021 Jun 10;384(23):2219-2228. doi: 10.1056/NEJMsa2032271. Abstract Background: Documenting current trends in diabetes treatment and risk-factor control may inform public health policy and planning. Methods: We conducted a cross-sectional analysis of data from adults with diabetes in the […]

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ARTICLE: Treatment of Acute Pain in Adults With Sickle Cell Disease in an Infusion Center Versus the Emergency Department : A Multicenter Prospective Cohort Study AUTHORS: Sophie Lanzkron, Jane Little, Hang Wang, Joshua J Field, J Ryan Shows, Carlton Haywood Jr, Mustapha Saheed, Marc Proudford, Derek Robertson, Adrienne Kincaid, Lorri Burgess, Charles Green, Rebecca Seufert, Jasmine Brooks, Allie Piehet, Brandi Griffin, Nicole Arnold, Steven Frymark, Marcus Wallace, Nebras Abu Al Hamayel, Chiung-Yu Huang, Jodi B Segal, Ravi […]

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ARTICLE: Racial Disparities in Cardiovascular Complications With Pregnancy-Induced Hypertension in the United States AUTHORS: Anum S Minhas, S Michelle Ogunwole, Arthur Jason Vaught, Pensee Wu, Mamas A Mamas, Martha Gulati, Di Zhao, Allison G Hays, Erin D Michos JOURNAL: Hypertension. 2021 Jun 8;HYPERTENSIONAHA12117104. doi: 10.1161/HYPERTENSIONAHA.121.17104. Online ahead of print. Abstract Women with pregnancy-induced hypertension, defined as gestational hypertension and preeclampsia/eclampsia, are at increased risk of long-term […]

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ARTICLE: Genome sequencing unveils a regulatory landscape of platelet reactivity AUTHORS: Ali R Keramati, Ming-Huei Chen, Benjamin A T Rodriguez, Lisa R Yanek, Arunoday Bhan, Brady J Gaynor, Kathleen Ryan, Jennifer A Brody, Xue Zhong, Qiang Wei, NHLBI Trans-Omics for Precision (TOPMed) Consortium; Kai Kammers, Kanika Kanchan, Kruthika Iyer, Madeline H Kowalski, Achilleas N Pitsillides, L Adrienne Cupples, Bingshan Li, Thorsten M Schlaeger, Alan R Shuldiner, Jeffrey R O'Connell, Ingo Ruczinski, Braxton D Mitchell, Nauder Faraday, Margaret A Taub, Lewis […]

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ARTICLE: Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association AUTHORS: Abdulla A Damluji, Daniel E Forman, Sean van Diepen, Karen P Alexander, Robert L Page 2nd, Scott L Hummel, Venu Menon, Jason N Katz, Nancy M Albert, Jonathan Afilalo, Mauricio G Cohen, American Heart Association Council on […]

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ARTICLE: Emphysema progression and lung function decline among angiotensin converting enzyme inhibitors (ACEi) and angiotensin-receptor blockade (ARB) users in the COPDGene® Cohort AUTHORS: Vickram Tejwani, Ashraf Fawzy, Nirupama Putcha, Peter Castaldi, Michael H Cho, Katherine A Pratte, Surya P Bhatt, David A Lynch, Stephen M Humphries, Gregory L Kinney, Franco R D'Alessio, Nadia N Hansel JOURNAL: Chest. 2021 May 21;S0012-3692(21)00898-9. doi: 10.1016/j.chest.2021.05.007. Online ahead of print. Abstract Background: Attenuation of […]

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