ARTICLE: Kynurenines link chronic inflammation to functional decline and physical frailty AUTHORS: Reyhan Westbrook, Tae Chung, Jacqueline Lovett, Chris Ward, Humberto Joca, Huanle Yang, Mohammed Khadeer, Jing Tian, Qian-Li Xue, Anne Le, Luigi Ferrucci, Ruin Moaddel, Rafa de Cabo, Ahmet Hoke, Jeremy Walston, Peter M Abadir JOURNAL: JCI Insight. 2020 Aug 20;5(16):e136091. doi: 10.1172/jci.insight.136091. Abstract Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms […]
Article of the Week
Outcomes of Acute Myocardial Infarction Hospitalizations During the COVID-19 Pandemic
Posted by | Article of the WeekARTICLE: Outcomes of Acute Myocardial Infarction Hospitalizations During the COVID-19 Pandemic AUTHORS: Margaret Krasne, Tyler J. Gluckman, Joseph Edward Marine, Roger S. Blumenthal, Garima Sharma JOURNAL: JACC. 2020 Aug 24. Introduction The 2019 novel coronavirus (COVID-19) pandemic is the greatest public health crisis of this century, with both the case rate and death toll continuing to rise.1 The pandemic […]
A deliberate path toward diversity, equity, and inclusion within the ASCI
Posted by | Article of the WeekARTICLE: A deliberate path toward diversity, equity, and inclusion within the ASCI AUTHORS: Lorraine B Ware, Kathleen L Collins, John B Hawley, Rexford S Ahima JOURNAL: J Clin Invest. 2020 Aug 24;142423. doi: 10.1172/JCI142423. Online ahead of print. Throughout the spring and summer of 2020, systemic racism and inequality have been brought into sharp focus across the United States. While much […]
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
Posted by | Article of the WeekARTICLE: Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy AUTHORS: Elizabeth D. Luczak, Yuejin Wu, Jonathan M. Granger, Mei-ling A. Joiner, Nicholas R. Wilson, Ashish Gupta, Priya Umapathi, Kevin R. Murphy, Oscar E. Reyes Gaido, Amin Sabet, Eleonora Corradini, Wen-Wei Tseng, Yibin Wang, Albert J. R. Heck, An-Chi Wei, Robert G. Weiss & Mark […]
Comparison of Dietary and Exercise Recommendations on Both Sides of the Atlantic
Posted by | Article of the WeekARTICLE: Comparison of Dietary and Exercise Recommendations on Both Sides of the Atlantic AUTHORS: Richard A Ferraro, Dorothy M Davis, Roger S. Blumenthal, Seth Shay Martin JOURNAL: J Am Coll Cardiol. 2020 Aug 24. Though pharmaceutical approaches for treating atherosclerotic cardiovascular disease (ASCVD) have experienced rapid growth, rightfully garnering a great deal of attention and publicity, lifestyle intervention […]
Endomyocardial Biopsy Characterization of Heart Failure With Preserved Ejection Fraction and Prevalence of Cardiac Amyloidosis
Posted by | Article of the WeekARTICLE: Endomyocardial Biopsy Characterization of Heart Failure With Preserved Ejection Fraction and Prevalence of Cardiac Amyloidosis AUTHORS: Virginia S. Hahn, Lisa R. Yanek, Joban Vaishnav, Wendy Ying, Dhananjay Vaidya, Yi Zhen Joan Lee, Sarah J. Riley, Vinita Subramanya, Emily E. Brown, C. Danielle Hopkins, Sandra Ononogbu, Kira Perzel Mandell, Marc K. Halushka, Charles Steenbergen Jr., Avi Z. Rosenberg, Ryan J. Tedford, Daniel P. Judge, Sanjiv J. Shah, Stuart D. Russell, David A. Kass and Kavita Sharma JOURNAL: […]
Effect of a Comprehensive Cardiovascular Risk Reduction Intervention in Persons With Serious Mental Illness: A Randomized Clinical Trial
Posted by | Article of the WeekARTICLE: Effect of a Comprehensive Cardiovascular Risk Reduction Intervention in Persons With Serious Mental Illness: A Randomized Clinical Trial AUTHORS: Gail L Daumit, Arlene T Dalcin, Faith B Dickerson, Edgar R Miller, A Eden Evins, Corinne Cather, Gerald J Jerome, Deborah R Young, Jeanne B Charleston, Joseph V Gennusa III, Stacy Goldsholl, Courtney Cook, Ann Heller, Emma E McGinty, Rosa M Crum, Lawrence J Appel, Nae-Yuh Wang JOURNAL: JAMA Netw Open. 2020 […]
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
Posted by | Article of the WeekARTICLE: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII AUTHORS: Klitos Konstantinidis, Vassilios J. Bezzerides, Lo Lai, Holly M. Isbell, An-Chi Wei, Yuejin Wu, Meera C. Viswanathan, Ian D. Blum, Jonathan M. Granger, Danielle Heims-Waldron, Donghui Zhang, Elizabeth D. Luczak, Kevin R. Murphy, Fujian Lu, Daniel H. Gratz, Bruno Manta, Qiang Wang, […]
Health equity and distributive justice considerations in critical care resource allocation
Posted by | Article of the WeekARTICLE: Health equity and distributive justice considerations in critical care resource allocation AUTHORS: Panagis Galiatsatos, Allen Kachalia, Harolyn M E Belcher, Mark T Hughes, Jeffrey Kahn, Cynda H Rushton, Jose I Suarez, Lee Daugherty Biddison and Sherita H Golden JOURNAL: Lancet Respir Med. 2020 Jun 22. doi: 10.1016/S2213-2600(20)30277-0 [Epub ahead of print] Amid the possibility of resource shortages in health care during a public […]
Empirical Antituberculosis Therapy in Advanced HIV Disease – Too Much, Too Late
Posted by | Article of the WeekARTICLE: Empirical Antituberculosis Therapy in Advanced HIV Disease - Too Much, Too Late AUTHORS: Richard E Chaisson JOURNAL: N Engl J Med. 2020 Jun 18;382(25):2459-2460. doi: 10.1056/NEJMe2009679. Despite the extraordinary advances in treating human immunodeficiency virus (HIV) infection during the past two decades, mortality, especially in resource-limited areas, remains unacceptably high. The leading killer of […]