ARTICLE: Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline AUTHORS: David J. Feller-Kopman, Chakravarthy B. Reddy, Malcolm M. DeCamp, Rebecca L. Diekemper, Michael K. Gould, Travis Henry, Narayan P. Iyer, Y. C. Gary Lee, Sandra Z. Lewis, Nick A. Maskell, Najib M. Rahman, Daniel H. Sterman, Momen M. Wahidi, and Alex A. Balekian JOURNAL: Am J Respir Crit Care Med. 2018 Oct 1;198(7):839-849. doi: 10.1164/rccm.201807-1415ST. Abstract BACKGROUND: This Guideline, a collaborative effort from the American Thoracic(...)
Article of the Week
Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity
Posted by | Article of the WeekARTICLE: Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity AUTHORS: Pardeep Kumar, F. Matthew Kuhlmann, Subhra Chakraborty, A. Louis Bourgeois, Jennifer Foulke-Abel, Brunda Tumala, Tim J. Vickers, David A. Sack, Barbara DeNearing, Clayton D. Harro, W. Shea Wright, Jeffrey C. Gildersleeve, Matthew A. Ciorba, Srikanth Santhanam, Chad K. Porter, Ramiro L. Gutierrez, Michael G.(...)
BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer
Posted by | Article of the WeekARTICLE: BRAF V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer AUTHORS: Fei Wang, Shihua Zhao, Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu,Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K. Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J. O’Neill, Mark S. Sywak,Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, Yangang Wang, and Mingzhao Xing JOURNAL: J Clin Oncol. 2018 Sep 20;36(27):2787-2795. doi: 10.1200/JCO.2018.78.5097. Epub(...)
Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia
Posted by | Article of the WeekARTICLE: Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia AUTHORS: Adityo Prakosa, Hermenegild J. Arevalo, Dongdong Deng, Patrick M. Boyle, Plamen P. Nikolov, Hiroshi Ashikaga, Joshua J. E. Blauer, Elyar Ghafoori, Carolyn J. Park, Robert C. Blake III, Frederick T. Han, Rob S. MacLeod, Henry R. Halperin, David J. Callans, Ravi Ranjan, Jonathan Chrispin, Saman Nazarian and Natalia A. Trayanova JOURNAL: Nat Biomed Eng. 2018 Sep 3. Doi: 10.1038/s41551-018-0282-2 Abstract(...)
Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance
Posted by | Article of the WeekARTICLE: Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance AUTHORS: Marcia Irene Canto, Jose Alejandro Almario, Richard D. Schulick, Charles J. Yeo, Alison Klein, Amanda Blackford, Eun Ji Shin, Abanti Sanyal, Gayane Yenokyan, Anne Marie Lennon, Ihab R. Kamel, Elliot K. Fishman, Christopher Wolfgang, Matthew Weiss, Ralph H. Hruban and Michael Goggins JOURNAL: Gastroenterology. 2018 Sep;155(3):740-751.e2. doi: 10.1053/j.gastro.2018.05.035. Epub 2018 May 24.(...)
Precardiac organoids form two heart fields via Bmp/Wnt signaling
Posted by | Article of the WeekARTICLE: Precardiac organoids form two heart fields via Bmp/Wnt signaling AUTHORS: Peter Andersen, Emmanouil Tampakakis, Dennisse V. Jimenez, Suraj Kannan, Matthew Miyamoto, Hye Kyung Shin, Amir Saberi, Sean Murphy, Edrick Sulistio, Stephen P. Chelko and Chulan Kwon JOURNAL: Nat Commun. 2018 Aug 7;9(1):3140. doi: 10.1038/s41467-018-05604-8. Abstract The discovery of the first heart field (FHF) and the second heart field (SHF) led us to understand how cardiac(...)
CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans
Posted by | Article of the WeekARTICLE: CMPK2 and BCL-G are associated with type 1 interferon–induced HIV restriction in humans AUTHORS: Ramy El-Diwany, Mary Soliman, Sho Sugawara, Florian Breitwieser, Alyza Skaist, Candelaria Coggiano, Neel Sangal, Michael Chattergoon, Justin R. Bailey, Robert F. Siliciano, Joel N. Blankson, Stuart C. Ray, Sarah J. Wheelan, David L. Thomas and Ashwin Balagopal JOURNAL: Sci Adv. 2018 Aug 1;4(8):eaat0843. doi: 10.1126/sciadv.aat0843. eCollection 2018 Aug. Abstract Type 1 interferons (IFN) are critical for host control(...)
Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine
Posted by | Article of the WeekARTICLE: Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine AUTHORS: Kavita Sharma, Joban Vaishnav, Rohan Kalathiya, Jiun-Ruey Hu, John Miller, Nishant Shah, Terence Hill, Michelle Sharp, Allison Tsao, Kevin M. Alexander, Richa Gupta, Kristina Montemayor, Lara Kovell, Jessica E. Chasler, Yizhen J. Lee, Derek M. Fine, David A. Kass, Robert G. Weiss, David R. Thiemann, Chiadi E. Ndumele, Steven P. Schulman, Stuart D. Russell and on behalf of Osler Medical House Staff JOURNAL: JACC Heart Fail. 2018 Aug(...)
Relation between alcohol consumption in midlife and dementia in late life
Posted by | Article of the WeekARTICLE: Relation between alcohol consumption in midlife and dementia in late life AUTHOR: Sevil Yasar JOURNAL: BMJ. 2018 Aug 1;362:k3164. doi: 10.1136/bmj.k3164. Alzheimer’s disease is a rapidly growing clinical and public health problem with currently no disease modifying therapies to treat or prevent the disease.1 Research suggests that pathological changes precede clinical symptoms by decades,2 resulting in an(...)
Which way does the axis tip? IBD increases the risk of Parkinson’s disease
Posted by | Article of the WeekARTICLE: Which way does the axis tip? IBD increases the risk of Parkinson’s disease AUTHORS: Susan Hutfless and Gregor K Wenning JOURNAL: Gut. 2018 Jun 1. pii: gutjnl-2018-316537. doi: 10.1136/gutjnl-2018-316537. [Epub ahead of print] In Gut, Villumsen et al1 report a statistically significant association between UC and the risk of parkinsonism in a Danish nested case–control study. Patients with Crohn’s(...)