Article of the Week

Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes

Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes

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ARTICLE: Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes. AUTHORS: James J. Chamberlain, William H. Herman, Sandra Leal, Andrew S. Rhinehart, Jay H. Shubrook, Neil Skolnik, Rita Rastogi Kalyani JOURNAL: Ann Intern Med. 2017 Mar 14. doi: 10.7326/M16-2937. [Epub ahead of print] Abstract DESCRIPTION: The American Diabetes Association (ADA) annually updates the Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the(...)

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Association of a Community Campaign for Better Beverage Choices With Beverage Purchases From Supermarkets

Association of a Community Campaign for Better Beverage Choices With Beverage Purchases From Supermarkets

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ARTICLE: Association of a Community Campaign for Better Beverage Choices With Beverage Purchases From Supermarkets AUTHORS: Marlene B. Schwartz, Glenn E. Schneider, Yoon-Young Choi, Xun Li, Jennifer Harris, Tatiana Andreyeva, Maia Hyary, Nicolette Highsmith Vernick, Lawrence J. Appel JOURNAL: JAMA Intern Med. 2017 Mar 6. doi: 10.1001/jamainternmed.2016.9650. [Epub ahead of print] Abstract IMPORTANCE: Data are needed to evaluate community interventions to reduce consumption of sugary drinks. Supermarket sales data can be used for(...)

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Chilling Effect? Post-Election Health Care Use by Undocumented and Mixed-Status Families

Chilling Effect? Post-Election Health Care Use by Undocumented and Mixed-Status Families

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ARTICLE: Chilling Effect? Post-Election Health Care Use by Undocumented and Mixed-Status Families AUTHORS: Kathleen R. Page and Sarah Polk JOURNAL: N Engl J Med. 2017 Mar 23;376(12):e20. doi: 10.1056/NEJMp1700829. Epub 2017 Mar 8. A pregnant woman from Central America was diagnosed with syphilis at the Baltimore City Health Department in 2007. The outreach team contacted her(...)

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Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

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ARTICLE: Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis AUTHORS: Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale,(...)

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FDA Regulation of Prescription Drugs

FDA Regulation of Prescription Drugs

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ARTICLE: FDA Regulation of Prescription Drugs AUTHORS: Audrey L. Gassman, Christine P. Nguyen and Hylton V. Joffe JOURNAL: N Engl J Med. 2017 Feb 16;376(7):674-682. doi: 10.1056/NEJMra1602972. In 2015, approximately 4 billion prescriptions were filled at retail pharmacies in the United States.1 The Center for Drug Evaluation and Research (CDER) within the Food and Drug Administration (FDA)(...)

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International Exchange and American Medicine

International Exchange and American Medicine

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ARTICLE: International Exchange and American Medicine AUTHORS: Katrina Armstrong, Mark E. Anderson, John M. Carethers, Joseph Loscalzo, Michael S. Parmacek, Robert M. Wachter and Mark L. Zeidel JOURNAL: N Engl J Med. 2017 Feb 1. doi: 10.1056/NEJMp1701339. [Epub ahead of print] On January 27, 2017, President Donald Trump issued an executive order suspending “entry into the(...)

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A View from the Front Line — Physicians’ Perspectives on ACA Repeal

A View from the Front Line — Physicians’ Perspectives on ACA Repeal

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ARTICLE: A View from the Front Line — Physicians’ Perspectives on ACA Repeal AUTHORS: Craig Evan Pollack, Katrina Armstrong and David Grande JOURNAL: N Engl J Med. 2017 Feb 9;376(6):e8. doi: 10.1056/NEJMp1700144. Epub 2017 Jan 25. The recent election of Donald Trump as President of the United States has created substantial uncertainty about the future of(...)

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Wearable Technology and Long-term Weight Loss

Wearable Technology and Long-term Weight Loss

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ARTICLE: Wearable Technology and Long-term Weight Loss AUTHORS: Timothy Plante and Seth Martin JOURNAL: JAMA. 2017 Jan 17;317(3):318-319. doi: 10.1001/jama.2016.19265. To the Editor After successful weight loss with weekly group sessions over the initial 6 months of the IDEA trial, individuals randomized to an enhanced intervention group using a physical activity tracking device regained more weight over(...)

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Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes

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ARTICLE: Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes AUTHORS: Peter M. Abadir, Alka Jain, Laura J. Powell, Qian-Li Xue, Jing Tian, Robert G. Hamilton, David A. Bennett, Thomas Finucane, Jeremy D. Walston, Neal S. Fedarko JOURNAL: Circulation. 2017 Jan 31;135(5):449-459. doi: 10.1161/CIRCULATIONAHA.116.022385. Epub 2016 Nov 30. Abstract BACKGROUND: Agonistic angiotensin II type 1 receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or(...)

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Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

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ARTICLE: Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy AUTHORS: Thomas P. Mast, Cynthia A. James, Hugh Calkins, Arco J. Teske, Crystal Tichnell, Brittney Murray, Peter Loh, Stuart D. Russell, Birgitta K. Velthuis, Daniel P. Judge, Dennis Dooijes, Ryan J. Tedford, Jeroen F. van der Heijden, Harikrishna Tandri, Richard N. Hauer, Theodore P. Abraham, Pieter A. Doevendans, Anneline S. J. M. te Riele, Maarten J. Cramer JOURNAL: JAMA Cardiol. 2017 Jan 11. doi: 10.1001/jamacardio.2016.5034. [Epub ahead of print] Abstract IMPORTANCE: Considerable research has described the arrhythmic course of arrhythmogenic right ventricular dysplasia/cardiomyopathy(...)

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