Article of the Week

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults

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ARTICLE: Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults. AUTHORS: Stephen P. Juraschek, Natalie Daya, Andreea M. Rawlings, Lawrence J. Appel, Edgar R. Miller III, B. Gwen Windham, Michael E. Griswold, Gerardo Heiss, Elizabeth Selvin JOURNAL: JAMA Intern Med. 2017 Jul 24. doi: 10.1001/jamainternmed.2017.2937. [Epub ahead of print] Abstract IMPORTANCE: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after(...)

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

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ARTICLE: Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice AUTHORS: Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal, Peter P. Rainer, Julia G. Bindman, Elizabeth E. Gerber, Djahida Bedja, Christopher Schiefer, Karen L. Miller, Guangshuo Zhu, Loretha Myers, Nuria Amat-Alarcon, Dong I. Lee, Norimichi Koitabashi, Daniel P. Judge, David A. Kass and Harry C. Dietz JOURNAL: JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. [Epub(...)

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Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

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ARTICLE: Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration AUTHORS: E. Fabian Cardozo, Adriana Andrade, John W. Mellors, Daniel R. Kuritzkes, Alan S. Perelson, Ruy M. Ribeiro JOURNAL: PLoS Pathog. 2017 Jul 5;13(7):e1006478. doi: 10.1371/journal.ppat.1006478. eCollection 2017 Jul. Abstract The kinetics of HIV-1 decay under treatment depends(...)

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Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review

Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review

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ARTICLE: Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy: A Narrative Review AUTHORS: Carl G. Streed Jr., Omar Harfouch, Francoise Marvel, Roger S. Blumenthal, Seth S. Martin, Monica Mukherjee JOURNAL: Ann Intern Med. 2017 Jul 25. doi: 10.7326/M17-0577. [Epub ahead of print] Abstract Recent reports estimate that 0.6% of adults in the United States, or approximately 1.4 million persons, identify(...)

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Biophysical and biomolecular determination of cellular age in humans

Biophysical and biomolecular determination of cellular age in humans

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ARTICLE: Biophysical and biomolecular determination of cellular age in humans AUTHORS: Jude M. Phillip, Pei-Hsun Wu, Daniele M. Gilkes, Wadsworth Williams, Shaun McGovern, Jena Daya, Jonathan Chen, Ivie Aifuwa, Jerry S. H. Lee, Rong Fan, Jeremy Walston, Denis Wirtz JOURNAL: Nature Biomedical Engineering. 2017 Jul 11; 10.1038 Abstract Ageing research has focused either on assessing organ- and tissue-based changes, such as lung capacity and cardiac(...)

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Trends in Use of High-Dose Vitamin D Supplements Exceeding 1000 or 4000 International Units Daily, 1999-2014

Trends in Use of High-Dose Vitamin D Supplements Exceeding 1000 or 4000 International Units Daily, 1999-2014

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ARTICLE: Trends in Use of High-Dose Vitamin D Supplements Exceeding 1000 or 4000 International Units Daily, 1999-2014 AUTHORS: Mary R. Rooney, Lisa Harnack, Erin D. Michos, Rachel P. Ogilvie, Christopher T. Sempos, Pamela L. Lutsey JOURNAL: JAMA. 2017 Jun 20;317(23):2448-2450. doi: 10.1001/jama.2017.4392. Since 2000, there has been an increase in research on possible health benefits of vitamin D. However, a 2011 Institute of Medicine (IOM; now the(...)

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Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol during Sleep

Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol during Sleep

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ARTICLE: Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol during Sleep. AUTHORS: Swati Chopra, Aman Rathore, Haris Younas, Luu V. Pham, Chenjuan Gu, Aleksandra Beselman, Il-Young Kim, Robert R. Wolfe, Jamie Perin, Vsevolod Y. Polotsky, Jonathan C. Jun JOURNAL: J Clin Endocrinol Metab. 2017 Jun 8. doi: 10.1210/jc.2017-00619. [Epub ahead of print] Abstract CONTEXT: Obstructive sleep apnea (OSA) is associated with diabetes and cardiovascular disease. This association(...)

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Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association

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ARTICLE: Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. AUTHORS: Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn JOURNAL: Circulation. 2017 Jun 15. pii: CIR.0000000000000510. doi: 10.1161/CIR.0000000000000510. Abstract Cardiovascular disease (CVD) is the leading(...)

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Using Trial Eligibility to Personalize Statin Therapy Appears No More Accurate Than a Coin Flip in Determining High-Risk Status*

Using Trial Eligibility to Personalize Statin Therapy Appears No More Accurate Than a Coin Flip in Determining High-Risk Status*

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ARTICLE: Using Trial Eligibility to Personalize Statin Therapy Appears No More Accurate Than a Coin Flip in Determining High-Risk Status* AUTHORS: Roger S. Blumenthal, M. Imran Aslam, William McEvoy JOURNAL: JACC Cardiovasc Imaging. 2017 Jun 9. pii: S1936-878X(17)30403-5. doi: 10.1016/j.jcmg.2017.02.019. [Epub ahead of print] Is it possible that around one-half of middle-aged adults estimated to be(...)

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How we treat central venous access device-related upper extremity DVT

How we treat central venous access device-related upper extremity DVT

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ARTICLE: How we treat central venous access device-related upper extremity DVT AUTHORS: Anita Rajasekhar and Michael B. Streiff JOURNAL: Blood 2017 :blood-2016-08-693671; doi: https://doi.org/10.1182/blood-2016-08-693671 Abstract Central venous access device (CVAD)-related thrombosis (CRT) is a common complication among patients requiring central venous access as part of their medical care. Complications of CRT include pulmonary embolism, recurrent deep venous thrombosis, loss of central venous(...)

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