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Medicine Matters Home Article of the Week SPIROMICS Protocol for Multicenter Quantitative CT to Phenotype the Lungs

SPIROMICS Protocol for Multicenter Quantitative CT to Phenotype the Lungs

ARTICLE: SPIROMICS Protocol for Multicenter Quantitative CT to Phenotype the Lungs

AUTHORS: Jered P Sieren, John D Newell, Jr., R. Graham Barr, Eugene R Bleecker, Nathan Burnette, Elizabeth E Carretta, David Couper, Jonathan Goldin, Junfeng Guo, MeiLan K Han, Nadia N Hansel, Richard E. Kanner, Ella A Kazerooni, Fernando J Martinez, Stephen Rennard, Prescott G Woodruff, Eric A. Hoffman and for the SPIROMICS Research Group

JOURNAL: Am J Respir Crit Care Med. 2016 Aug 2. [Epub ahead of print]


Multi-detector row computed tomography (MDCT) is increasingly taking a central role in identifying sub-phenotypes within chronic obstructive pulmonary disease (COPD), asthma and other lung-related disease populations, allowing for the quantification of the amount and distribution of altered parenchyma along with the characterization of airway and vascular anatomy. The embedding of quantitative CT (QCT) into a multi-center trial with a variety of scanner makes and models along with the variety of pressures within a clinical radiology setting have proven challenging, especially in the context of a longitudinal study. The national institute of health sponsored Sub-Populations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) has established a QCT lung assessment system (QCT-LAS) which includes scanner specific imaging protocols for lung assessment at total lung capacity and residual volume. Also included are monthly scanning of a standardized test object, and web-based tools for subject registration, protocol assignment, and data transmission coupled with automated image interrogation to assure protocol adherence. TheSPIROMICS QCT-LAS has been adopted and contributed to by a growing number of other multi-center studies in which imaging is embedded. The key components of the SPIROMICS QCT-LAS along with evidence of implementation success are described herein. While imaging technologies continue to evolve, the required components of a QCT-LAS provide the framework for future studies and the QCT results emanating fromSPIROMICS and the growing number of other studies utilizing the SPIROMICS QCT-LAS will provide a shared resource of image-derived pulmonary metrics.

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Kelsey Bennett