ARTICLE: Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?
AUTHORS: Thomaz Fleury Curado, Slava Berger and Vsevolod Y Polotsky
JOURNAL: Am J Respir Crit Care Med. 2018 Dec 6. doi: 10.1164/rccm.201811-2135ED. [Epub ahead of print]
Obstructive sleep apnea (OSA) is recurrent upper airway obstruction caused by a loss of upper airway muscle tone during sleep, which leads to intermittent hypoxia and sleep fragmentation1 . OSA is a common disorder affecting 25-30% of adult population and more than 50% of obese individuals 2 . Continuous positive airway pressure (CPAP) relieves OSA, but poor adherence severely limits its use 3 . Mandibular advancement devices have better compliance, but not as effective as CPAP 4 . There is no effective pharmacotherapy.
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