ARTICLE: Right Atrial Pacing to Improve Acute Hemodynamics in Pulmonary Arterial Hypertension
AUTHORS: Jasjeet S Khural, Brian A Houston, Peter J Leary, Stephen C Mathai, Todd M Kolb, Rachel Damico, Paul M Hassoun, David A Kass, Steven Hsu, Ryan J Tedford
JOURNAL: Am J Respir Crit Care Med. 2020 Oct 7. doi: 10.1164/rccm.202006-2278LE. Online ahead of print.
Right atrial (RA) pacing to increase heart rate is a therapeutic strategy in acute right ventricular (RV) infarction resulting in decrease in right atrial pressure and increases in cardiac output (CO) and systemic blood pressure.(1, 2) Additionally, RA pacing has been shown to increase RV contractility and CO after cardiac surgery.(3) However, the acute hemodynamic impact of RA pacing in patients with pulmonary arterial hypertension (PAH) has not been studied. In the current study, we report the hemodynamic response to RA pacing in a cohort of patients with PAH. Some results of this study were previously reported as an abstract presentation. (4)
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