Trends in the procurement and discard of kidneys from deceased donors with acute kidney injury

ARTICLE: Trends in the procurement and discard of kidneys from deceased donors with acute kidney injury

AUTHORS: Caroline Liu, Sami Alasfar, Peter P Reese, Sumit Mohan, Mona D Doshi, Isaac E Hall, Heather Thiessen PhilbrookYaqi Jia, Darren Stewart, Chirag R Parikh

JOURNAL: Am J Transplant. 2021 Dec 12. doi: 10.1111/ajt.16920. Online ahead of print.

Abstract

Kidney allocation trends from deceased donors with acute kidney injury (AKI) have not been characterized since initial Kidney Donor Profile Index reporting in 2012 and its use under the revised Kidney Allocation System (KAS) in 2014. We conducted a retrospective analysis of US registry data to characterize kidney procurement and discard trends in deceased donors with AKI, defined by ≥50% or ≥0.3 mg/dl (≥4.0 mg/dl or ≥200% for stage 3) increase in terminal serum creatinine from admission. From 2010 to 2020, 172 410 kidneys were procured from 93 341 deceased donors 16 years or older; 34 984 kidneys were discarded (17 559 from AKI donors). The proportion of stage 3 AKI donors doubled from 6% (412/6841) in 2010 to 12% (1365/11493) in 2020. Procurement of stage 3 AKI kidneys increased from 51% (423/824) to 80% (2183/2730). While discard of stage 3 AKI kidneys increased from 41% (175/423) in 2010 to 44% (960/2183) in 2020, this increase was not statistically significant in interrupted time-series analysis following KAS implementation (slope difference -0.41 [-3.22, 2.4], and level change 3.09 [-6.4, 12.6]). In conclusion, the absolute number of stage 3 AKI kidneys transplanted has increased. Ongoing high discard rates of these kidneys suggest opportunities for improved utilization.

For the full article, click here.

For a link to the abstract, click here.

Medscape: Kidneys From Donors With Acute Kidney Injury Often Unnecessarily Discarded