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Medicine Matters Home › Article of the Week › Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients

Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients

ARTICLE: Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients

AUTHORS: Bezawit A Woldemeskel, Caroline C Garliss, Tihitina Y Aytenfisu, Trevor S Johnston, Andrea L Cox, Andrew H Karaba, Joel N Blankson

JOURNAL: Clin Infect Dis. 2022 Oct 29;75(9):1652-1654. doi: 10.1093/cid/ciac305.

Abstract

We compared antibody and T-cell responses against the severe acute respiratory syndrome coronavirus 2 vaccine strain spike protein to responses against the Omicron variant in 15 messenger RNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T-cell responses.

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Kelsey Bennett