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Long-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses

ARTICLE: Long-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses

AUTHORS: Man-Fung Yuen 1, Scott Fung 2, Xiaoli Ma 3, Tuan T Nguyen 4, Tarek Hassanein 5, Hie-Won Hann 6, Magdy Elkhashab 7, Ronald G Nahass 8, James S Park 9, Ira M Jacobson 10, Walid S Ayoub 11, Steven-Huy Han 12, Edward J Gane 13, Katie Zomorodi 14, Ran Yan 14, Julie Ma 14, Steven J Knox 14, Luisa M Stamm 14, Maurizio Bonacini 15, Frank Weilert 16, Alnoor Ramji 17, Michael Bennett 18, Natarajan Ravendhran 19, Sing Chan 20, Douglas T Dieterich 21, Paul Yien Kwo 22, Eugene R Schiff 23, Ho S Bae 24, Jacob Lalezari 25, Kosh Agarwal, Mark S Sulkowski

JOURNAL: JHEP Rep. 2024 Jan 18;6(4):100999. doi: 10.1016/j.jhepr.2023.100999. eCollection 2024 Apr.


Background & aims: The investigational first-generation core inhibitor vebicorvir (VBR) demonstrated safety and antiviral activity over 24 weeks in two phase IIa studies in patients with chronic HBV infection. In this long-term extension study, patients received open-label VBR with nucleos(t)ide reverse transcriptase inhibitors (NrtIs).

Methods: Patients in this study (NCT03780543) previously received VBR + NrtI or placebo + NrtI in parent studies 201 (NCT03576066) or 202 (NCT03577171). After receiving VBR + NrtI for ≥52 weeks, stopping criteria (based on the treatment history and hepatitis B e antigen status in the parent studies) were applied, and patients either discontinued both VBR + NrtI, discontinued VBR only, or continued both VBR + NrtI. The primary efficacy endpoint was the proportion of patients with HBV DNA <20 IU/ml at 24 weeks off treatment.

Results: Ninety-two patients entered the extension study and received VBR + NrtI. Long-term VBR + NrtI treatment led to continued suppression of HBV nucleic acids and, to a lesser extent, HBV antigens. Forty-three patients met criteria to discontinue VBR + NrtI, with no patients achieving the primary endpoint; the majority of virologic rebound occurred ≥4 weeks off treatment. Treatment was generally well tolerated, with few discontinuations due to adverse events (AEs). There were no deaths. Most AEs and laboratory abnormalities were related to elevations in alanine aminotransferase and occurred during the off-treatment or NrtI-restart phases. No drug-drug interactions between VBR + NrtI and no cases of treatment-emergent resistance among patients who adhered to treatment were observed.

Conclusions: Long-term VBR + NrtI was safe and resulted in continued reductions in HBV nucleic acids following completion of the 24-week parent studies. Following treatment discontinuation, virologic relapse was observed in all patients. This first-generation core inhibitor administered with NrtI for at least 52 weeks was not sufficient for HBV cure.

Clinical trial number: NCT03780543.

Impact and implications: Approved treatments for chronic hepatitis B virus infection (cHBV) suppress viral replication, but viral rebound is almost always observed after treatment discontinuation, highlighting an unmet need for improved therapies with finite treatment duration producing greater therapeutic responses that can be sustained off treatment. First-generation core inhibitors, such as vebicorvir, have mechanisms of action orthogonal to standard-of-care therapies that deeply suppress HBV viral replication during treatment; however, to date, durable virologic responses have not been observed after treatment discontinuation. The results reported here will help researchers with the design and interpretation of future studies investigating core inhibitors as possible components of finite treatment regimens for patients with cHBV. It is possible that next-generation core inhibitors with enhanced potency may produce deeper and more durable antiviral activity than first-generation agents, including vebicorvir.

For the full article, click here.

For a link to the abstract, click here.


Kelsey Bennett

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