ARTICLE: Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients
AUTHORS: Trevor S Johnston, Camille Hage, Aura T Abedon, Snigdha Panda, Jennifer L Alejo, Yolanda Eby, Dorry L Segev, Aaron A R Tobian, Andrea L Cox, William A Werbel, Andrew H Karaba
JOURNAL: Clin Infect Dis. 2024 Jul 2:ciae279. doi: 10.1093/cid/ciae279. Online ahead of print.
Abstract
Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.
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