Dr. Shruti Chaturvedi, associate professor in the Division of Hematology, and Dr. Robert Brodsky, professor and director of the Division of Hematology, are principal investigators on a $7.8 million grant sponsored by the National Institutes of Health to study thrombotic microangiopathies over five years.
Thrombotic microangiopathies (TMA) including thrombotic thrombocytopenic purpura (TTP) and complement-mediated TMA (CM-TMA) are a group of rare disorders characterized by life-threatening acute episodes of systemic microvascular thrombosis. Despite advances in therapy for acute TMA episodes, long-term sequelae of TMAs including relapse, neurocognitive impairment, and cardiovascular disease contribute significantly to morbidity. This study will establish a well-phenotyped multicenter, prospective cohort and biological sample repository of individuals with TMA to study short and long-term outcomes of TMA, evaluate the impact of novel therapies on these outcomes, and to establish the infrastructure for future clinical trials in these rare diseases.
