Article of the Week

From Bench to Bedside: Animal Model Leads to Novel, 1-month TB Preventive Therapy Identification and treatment of individuals with latent tuberculosis (TB) infection to prevent… Read More »One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis

ARTICLE: Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules AUTHORS: Jeffrey H. Silber, Lisa M. Bellini, Judy A. Shea, Sanjay V. Desai, David F. Dinges, Mathias Basner, Orit Even-Shoshan, Alexander S. Hill, Lauren L.… Read More »Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

ARTICLE: Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity AUTHORS: Ling Li*, Hildur Knutsdottir, Ken Hui*, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban… Read More »Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

ARTICLE: Caring for Patients With Multiple Chronic Conditions AUTHORS: Mary E. Tinetti, Ariel R. Green, Jennifer Ouellet, Michael W. Rich, Cynthia Boyd JOURNAL: Ann Intern… Read More »Caring for Patients With Multiple Chronic Conditions

ARTICLE: Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability AUTHORS: Lindsay F. Rizzardi, Peter F. Hickey, Varenka Rodriguez DiBlasi, Rakel Tryggvadóttir, Colin M. Callahan, Adrian Idrizi, Kasper… Read More »Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

ARTICLE: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress AUTHORS: Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van… Read More »PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

ARTICLE: Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study AUTHORS: Zhixiong Wang, Swetha Kambhampati, Yulan Cheng, Ke Ma, Cem Simsek, Alan H Tieu, John M Abraham, Xi Liu, Vishnu Prasath, Mark D Duncan, Alejandro Stark, Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He, Mouen A Khashab, Saowanee Ngamruengphong, Eun J Shin, Tza-Huei Wang and Stephen J. Meltzer… Read More »Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study

ARTICLE: Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use AUTHORS: Alexandra T. Strauss, Theodore W. James… Read More »Fellow Education Improved Through Mobile Clinical Decision Support Application: A Multi Center Approach Involving Peri-Procedural Antithrombotic Use

ARTICLE: Substance-Use Disorders in Later Life AUTHORS: Susan W. Lehmann and Michael Fingerhood JOURNAL: NEJM. 2018 Dec 13.doi: 10.1056/NEJMra1805981 Substance-use disorders have been declared a national… Read More »Substance-Use Disorders in Later Life

ARTICLE: Rural Residence and Poverty are Independent Risk Factors for COPD in the United States AUTHORS: Sarath Raju, Corinne A Keet, Laura M Paulin, Elizabeth C Matsui, Roger D… Read More »Rural Residence and Poverty are Independent Risk Factors for COPD in the United States