Article of the Week

ARTICLE: Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project AUTHORS:… Read More »Fitness and 10-year risk of mortality among adults ≥70 years old at the extremes of cardiovascular disease risk factor burden: the FIT Project

ARTICLE: Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time AUTHORS: Rhanderson Cardoso, Khurram Nasir, Roger… Read More »Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time

ARTICLE: Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial… Read More »Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial

From Bench to Bedside: Animal Model Leads to Novel, 1-month TB Preventive Therapy Identification and treatment of individuals with latent tuberculosis (TB) infection to prevent… Read More »One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis

ARTICLE: Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules AUTHORS: Jeffrey H. Silber, Lisa M. Bellini, Judy A. Shea, Sanjay V. Desai, David F. Dinges, Mathias Basner, Orit Even-Shoshan, Alexander S. Hill, Lauren L.… Read More »Patient Safety Outcomes Under Flexible and Standard Resident Duty-Hour Rules

ARTICLE: Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity AUTHORS: Ling Li*, Hildur Knutsdottir, Ken Hui*, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban… Read More »Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

ARTICLE: Caring for Patients With Multiple Chronic Conditions AUTHORS: Mary E. Tinetti, Ariel R. Green, Jennifer Ouellet, Michael W. Rich, Cynthia Boyd JOURNAL: Ann Intern… Read More »Caring for Patients With Multiple Chronic Conditions

ARTICLE: Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability AUTHORS: Lindsay F. Rizzardi, Peter F. Hickey, Varenka Rodriguez DiBlasi, Rakel Tryggvadóttir, Colin M. Callahan, Adrian Idrizi, Kasper… Read More »Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

ARTICLE: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress AUTHORS: Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van… Read More »PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

ARTICLE: Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study AUTHORS: Zhixiong Wang, Swetha Kambhampati, Yulan Cheng, Ke Ma, Cem Simsek, Alan H Tieu, John M Abraham, Xi Liu, Vishnu Prasath, Mark D Duncan, Alejandro Stark, Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He, Mouen A Khashab, Saowanee Ngamruengphong, Eun J Shin, Tza-Huei Wang and Stephen J. Meltzer… Read More »Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett’s Esophagus: A Prospective Validation Study