Medicine Matters

Sharing successes, challenges and daily happenings in the Department of Medicine

AOTW

Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis

July 15, 2015

ARTICLE: Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis AUTHORS: Allison A. Lambert, Jennifer O. Lam, Julie J. Paik, Cesar Ugarte-Gil, M. Bradley Drummond, Trevor A. Crowell JOURNAL: PLoS One. 2015 Jun 4;10(6):e0128004. doi: 10.1371/journal.pone.0128004. eCollection 2015. Abstract BACKGROUND: Proton-pump inhibitors (PPIs) are among the most frequently prescribed medications. […]

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kbennett ⋅ Article of the Week

AOTW

Citrullination of myofilament proteins in heart failure

July 8, 2015

ARTICLE: Citrullination of myofilament proteins in heart failure AUTHORS: J. Fert-Bober, J.T. Giles, R.J. Holewinski, J.A. Kirk, H. Uhrigshardt, E.L. Crowgey, F. Andrade, C.O. Bingham 3rd, J.K. Park, M.K. Halushka, D.A. Kass, J.M. Bathon and J.E. Van Eyk JOURNAL: Cardiovasc Res. 2015 Jun 25. pii: cvv185. [Epub ahead of print] Abstract AIM: Citrullination, the post-translational […]

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kbennett ⋅ Article of the Week

AOTW

Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle

July 1, 2015

ARTICLE: Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle AUTHORS: Genaro A. Ramirez-Correa, Junfeng Ma, Chad Slawson, Quira Zeidan, Nahyr S. Lugo-Fagundo, Mingguo Xu, Xiaoxu Shen, Wei Dong Gao, Viviane Caceres, Khalid Chakir, Lauren DeVine, Robert Cole, Luigi Marchionni, Nazareno Paolocci, Gerald W. Hart and Anne M. Murphy JOURNAL: Diabetes. 2015 Jun […]

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kbennett ⋅ Article of the Week

AOTW

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

June 24, 2015

ARTICLE: Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart AUTHORS: Gaurav Kaushik, Alice Spenlehauer, Ayla O. Sessions, Adriana S. Trujillo, Alexander Fuhrmann, Zongming Fu, Vidya Venkatraman, Danielle Pohl, Jeremy Tuler, Mingyi Wang, Edward G. Lakatta, Karen Ocorr, Rolf Bodmer, Sanford I. Bernstein, Jennifer E. Van Eyk, Anthony Cammarato and Adam J. Engler […]

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kbennett ⋅ Article of the Week

AOTW

Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management

June 17, 2015

ARTICLE: Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management AUTHOR: Gordon F. Tomaselli JOURNAL: Circulation Research. June 5, 2015; Vol. 116, No. 12 Overview of Sudden Cardiac Death and Scope of the Compendium Sudden cardiac death (SCD) is a devastating complication of many forms of heart disease and on occasion presents […]

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kbennett ⋅ Article of the Week

AOTW

Atypical HUS may become a diagnosis of inclusion

June 10, 2015

ARTICLE: Atypical HUS may become a diagnosis of inclusion AUTHORS: J. Evan Sadler JOURNAL: Blood. 2015 Jun 4;125(23):3525-6. doi: 10.1182/blood-2015-04-640656 Patients with aHUS usually have microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. However, these features occur in many diseases, including thrombotic thrombocytopenic purpura (TTP), and the more common form of Shiga toxin–expressing Escherichia coli hemolytic […]

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kbennett ⋅ Article of the Week

AOTW

Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage

June 3, 2015

ARTICLE: Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage AUTHOURS: Yulan Cheng, Ana P. Kiess, Joseph M. Herman, Martin G. Pomper, Stephen J. Meltzer, John M. Abraham JOURNAL: PLoS One. 2015 Jun 1;10(6):e0128152. doi: 10.1371/journal.pone.0128152. eCollection 2015. Abstract Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill […]

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kbennett ⋅ Article of the Week Gastroenterology ⋅

AOTW

Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population

May 27, 2015

ARTICLE: Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population AUTHORS: Waseem Khaliq, Rehan Qayyum Jeffrey Clough, Dhananjay Vaidya, Antonio C. Wolff, Diane M. Becker JOURNAL: Breast Cancer Res Treat. 2015 Jun;151(2):465-74. doi: 10.1007/s10549-015-3412-5. Epub  2015 May 10. Abstract Studies have suggested a decreased breast cancer risk […]

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kbennett ⋅ Article of the Week General Internal Medicine ⋅

AOTW

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

May 20, 2015

ARTICLE: A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury AUTHORS: Matthew T. James, Morgan E. Grams, Mark Woodward, C. Raina Elley, Jamie A. Green, David C. Wheeler, Paul de Jong, Ron T. Gansevoort, Andrew S. Levey, David G. Warnock, Mark J. Sarnak JOURNAL: Am J Kidney […]

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kbennett ⋅ Article of the Week Nephrology ⋅

AOTW

Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort

May 13, 2015

ARTICLE: Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort AUTHORS: Jason I Feinberg, Kelly M Bakulski, Andrew E Jaffe, Rakel Tryggvadottir, Shannon C Brown, Lynn R Goldman, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, M Daniele Fallin, Andrew P Feinberg JOURNAL: Int J Epidemiol. 2015 Apr 14. […]

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kbennett ⋅ Article of the Week

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About the Director

Mark Anderson, M.D., Ph.D - William Osler Professor of Medicine, director of the Department of Medicine in the Johns Hopkins University School of Medicine

Mark Anderson, M.D., Ph.D is the William Osler Professor of Medicine, director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital... read more »

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Medicine Matters is a place to share department news in a way that is accessible to all and discuss issues and challenges important to our faculty, staff and academic medicine overall... read more »

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