Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

ARTICLE: Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

AUTHORS: Rebekah M. Dedrick, Krista G. Freeman, Jan A. Nguyen, Asli Bahadirli-Talbott, Bailey E. Smith, Andrew E. Wu, Aaron S. Ong, Cheng Ting Lin, Lisa C. Ruppel, Nicole M. Parrish, Graham F. Hatfull & Keira A. Cohen

JOURNAL: Nat Med. 2021 Aug;27(8):1357-1361. doi: 10.1038/s41591-021-01403-9. Epub 2021 Jul 8.

Abstract

An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month. However, after two months, M. abscessus counts increased as the patient mounted a robust IgM- and IgG-mediated neutralizing antibody response to the phages, which was associated with limited therapeutic efficacy.

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