Article of the Week

Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis

Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis

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ARTICLE: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis AUTHORS: Nisa M. Maruthur, Eva Tseng, Susan Hutfless, Lisa M. Wilson, Catalina Suarez-Cuervo, Zackary Berger, Yue Chu, Emmanuel Iyoha, Jodi B. Segal and Shari Bolen JOURNAL: Ann Intern Med. 2016 Apr 19. doi: 10.7326/M15-2650. [Epub ahead of print](...)

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Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study

Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study

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ARTICLE: Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study AUTHORS: Carolina Montano, Margaret A. Taub, Andrew Jaffe, Eirikur Briem, Jason I. Feinberg, Rakel Trygvadottir, Adrian Idrizi, Arni Runarsson, Birna Berndsen, Ruben C. Gur, Tyler M. Moore, Rodney T. Perry, Doug Fugman, Sarven Sabunciyan, Robert H. Yolken, Thomas M. Hyde, Joel E. Kleinman, Janet L. Sobell, Carlos N. Pato, Michele T. Pato, Rodney C. Go, Vishwajit Nimgaonkar, Daniel R. Weinberger, David Braff, Raquel E. Gur, Margaret Daniele Fallin, Andrew(...)

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Evaluation of the Centers for Disease Control and Prevention Recommendations for Hepatitis C Virus Testing in an Urban Emergency Department

Evaluation of the Centers for Disease Control and Prevention Recommendations for Hepatitis C Virus Testing in an Urban Emergency Department

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ARTICLE: Evaluation of the Centers for Disease Control and Prevention Recommendations for Hepatitis C Virus Testing in an Urban Emergency Department AUTHORS: Yu-Hsiang Hsieh, Richard E. Rothman, Oliver B. Laeyendecker, Gabor D. Kelen, Ama Avornu, Eshan U. Patel, Jim Kim, Risha Irvin, David L. Thomas and Thomas C. Quinn JOURNAL: Clin Infect Dis. 2016 May 1;62(9):1059-65. doi: 10.1093/cid/ciw074.(...)

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Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy

Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy

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ARTICLE: Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy AUTHORS: Cesar A. Santa-Maria, Amanda Blackford, Anne T. Nguyen, Todd C. Skaar, Santosh Philips, Steffi Oesterreich, James M. Rae, Zeruesenay Desta, Jason Robarge, Norah Lynn Henry, Anna M. Stornioio, Daniel F. Hayes, Roger S.(...)

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Antimicrobial Access in the 21st Century: Delays and Critical Shortages

Antimicrobial Access in the 21st Century: Delays and Critical Shortages

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ARTICLE: Antimicrobial Access in the 21st Century: Delays and Critical Shortages AUTHORS: Shmuel Shoham, Annukka Antar, Paul Auwaerter, Christine Durand, Mark Sulkowski and Deborah Cotton JOURNAL: Ann Intern Med. 2016 Mar 22. doi: 10.7326/M15-3076. [Epub ahead of print] A young woman with a bone marrow transplant and relapsed leukemia is placed on a regimen of the antibiotic(...)

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Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

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ARTICLE: Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial AUTHORS: Mina C Hosseinipour, Gregory P Bisson, Sachiko Miyahara, Xin Sun, Agnes Moses, Cynthia Riviere, Fredrick K Kirui, Sharlaa Badal-Faesen, David Lagat, Mulinda Nyirenda, Kogieleum Naidoo, James Hakim, Peter Mugyenyi, German Henostroza, Paul(...)

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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

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ARTICLE: Epigenetic modulators, modifiers and mediators in cancer aetiology and progression AUTHORS: Andrew P. Feinberg, Michael A. Koldobskiy, Anita Göndör JOURNAL: Nat Rev Genet. 2016 Mar 14. doi: 10.1038/nrg.2016.13. [Epub ahead of print] Abstract This year is the tenth anniversary of the publication in this journal of a model suggesting the existence of 'tumour progenitor genes'.(...)

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Misanalysis of Urinalysis: A Teachable Moment

Misanalysis of Urinalysis: A Teachable Moment

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ARTICLE: Misanalysis of Urinalysis: A Teachable Moment AUTHORS: Kathryn B. Holroyd, Alexander Rittenberg and Amit Pahwa JOURNAL: JAMA Intern Med. 2016 Mar 7. doi: 10.1001/jamainternmed.2016.0067. [Epub ahead of print] A 64-year-old woman with a history of Bertolotti syndrome causing chronic low back pain presented to the emergency department because she was experiencing medication withdrawal symptoms. She had recently stopped her home(...)

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Validation of the Instant Blood Pressure Smartphone App

Validation of the Instant Blood Pressure Smartphone App

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ARTICLE: Validation of the Instant Blood Pressure Smartphone App AUTHORS: Timothy B. Plante, Bruno Urrea, Zane T. MacFarlane, Roger S. Blumenthal, Edgar R. Miller III, Lawrence J. Appel and Seth S. Martin JOURNAL: JAMA Intern Med. 2016 Mar 2. doi: 10.1001/jamainternmed.2016.0157. [Epub ahead of print] Abstract Mobile health (mHealth) technologies include unregulated consumer smartphone apps.1 The Instant Blood Pressure app (IBP; AuraLife) estimates blood pressure (BP) using a technique in which(...)

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Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

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ARTICLE: Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women AUTHORS: Jared M. Baeten, Thesla Palanee-Phillips, Elizabeth R. Brown, Katie Schwartz, Lydia E. Soto-Torres, Vaneshree Govender, Nyaradzo M. Mgodi, Flavia Matovu Kiweewa, Gonasagrie Nair, Felix Mhlanga, Samantha Siva, Linda-Gail Bekker, Nitesha Jeenarain, Zakir Gaffoor, Francis Martinson, Bonus Makanani, Arendevi Pather, Logashvari Naidoo, Marla Husnik, Barbra A. Richardson, Urvi M. Parikh,(...)

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