Article of the Week

Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use

Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use

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ARTICLE: Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use AUTHORS: Piggott DA, Varadhan R, Mehta SH, Brown TT, Li H, Walston JD, Leng SX, Kirk GD JOURNAL: J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1542-1547. Epub 2015 Sep 18. Abstract BACKGROUND: Serum markers of inflammation increase with age and have been strongly associated with adverse(...)

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Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?

Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?

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ARTICLE: Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?: The Coronary Artery Risk Development in Young Adults (CARDIA) Study and the Multi-Ethnic Study of Atherosclerosis (MESA) AUTHORS: Liu K, Colangelo LA, Daviglus ML, Goff DC, Pletcher M, Schreiner PJ, Sibley CT, Burke GL, Post WS, Michos ED, Lloyd-Jones DM JOURNAL: J Am Heart Assoc. 2015 Sep 21;4(9). pii: e002275. doi: 10.1161/JAHA.115.002275.(...)

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Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

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ARTICLE: Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment AUTHORS: Chan AT, Karakas MF, Vakrou S, Afzal J, Rittenbach A, Lin X, Wahl RL, Pomper MG, Steenbergen CJ, Tsui BM, Elisseeff JH, Abraham MR JOURNAL: Biomaterials. 2015 Dec;73:1-11. doi: 10.1016/j.biomaterials.2015.09.001. Epub 2015 Sep 4. Abstract BACKGROUND: Cell death due to anoikis, necrosis and cell egress from transplantation sites limits functional benefits(...)

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Genomics: The interloper

Genomics: The interloper

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ARTICLE: Genomics: The interloper AUTHORS: M. Teresa Villanueva JOURNAL: Nat Rev Genet. 2015 Sep 18;16(10):564-5. doi: 10.1038/nrg4009 Article The retrotransposon long interspersed element-1 (LINE-1) is a mobile genetic sequence that can lead to mutagenesis and genetic instability by copying and inserting itself into the genome. LINE-1 insertions have been reported in tumour suppressor genes in several(...)

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Economic and Epidemiological Impact of Early Antiretroviral Therapy Initiation in India

Economic and Epidemiological Impact of Early Antiretroviral Therapy Initiation in India

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ARTICLE: Economic and Epidemiological Impact of Early Antiretroviral Therapy Initiation in India AUTHORS: Manoj V Maddali, David W Dowdy, Amita Gupta, Maunank Shah JOURNAL: J Int AIDS Soc. 2015, 18:20217 Abstract INTRODUCTION: Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies(...)

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Ambrisentan and Tadalafil Upfront Combination Therapy in Scleroderma-Associated PAH

Ambrisentan and Tadalafil Upfront Combination Therapy in Scleroderma-Associated PAH

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ARTICLE: Ambrisentan and Tadalafil Upfront Combination Therapy in Scleroderma-Associated PAH AUTHORS: Paul M Hassoun, Roham T Zamanian, Rachel Damico, Noah Lechtzin, Rubina Khair, Todd M Kolb, Ryan J Tedford, Olivia L Hulme, Traci Housten, Chiara Pisanello, Takahiro Sato, Erica H Pullins, Celia P Corona-Villalobos, Stefan L Zimmerman, Mohamed A Gashouta, Omar A Minai, Fernando Torres, Reda E Girgis, Kelly Chin, and Stephen C Mathai JOURNAL: Am J Respir Crit Care Med. 2015 Sep 11. [Epub(...)

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Satisfaction with primary care provider involvement is associated with greater weight loss: Results from the practice-based POWER trial

Satisfaction with primary care provider involvement is associated with greater weight loss: Results from the practice-based POWER trial

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ARTICLE: Satisfaction with primary care provider involvement is associated with greater weight loss: Results from the practice-based POWER trial AUTHORS: Wendy L. Bennett, Nae-Yuh Wang, Kimberly A. Gudzune, Arlene T. Dalcin, Sara N. Bleich, Lawrence J. Appel, Jeanne M. Clark JOURNAL: Patient Educ Couns. 2015 Sep;98(9):1099-105. doi: 10.1016/j.pec.2015.05.006. Epub 2015 May 27 Abstract OBJECTIVE: To evaluate(...)

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Contraceptive Use and Factors Associated With Postpartum Surgical Sterilization Among HIV-Infected Women in Pune, India

Contraceptive Use and Factors Associated With Postpartum Surgical Sterilization Among HIV-Infected Women in Pune, India

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ARTICLE: Contraceptive Use and Factors Associated With Postpartum Surgical Sterilization Among HIV-Infected Women in Pune, India AUTHORS: Nishi Suryavanshi, Vidya Mave, Nikhil Gupte, Ramesh Bhosale, Pradeep Sambarey, Sandesh Patil, Jayagowri Sastry, Robert Bollinger, Amita Gupta, Anita Shankar & The SWEN India Study Team JOURNAL: Journal of HIV/AIDS & Social Services, Volume 14, Issue 3, 2015(...)

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LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma

LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma

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ARTICLE: LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma AUTHORS: Tara T. Doucet-O’Hare, Nemanja Rodic, Reema Sharma, Isha Darbari, Gabriela Abril, Jungbin A. Choi, Ji Young Ahn, Yulan Cheng, Robert A. Anders, Kathleen H. Burns, Stephen J. Meltzer and Haig H. Kazazian, Jr. JOURNAL: Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4894-900. doi: 10.1073/pnas.1502474112. Epub 2015 Aug 17 Abstract Barrett's esophagus (BE) is(...)

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Invisible Colleagues

Invisible Colleagues

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ARTICLE: Invisible Colleagues AUTHORS: Benjamin J. Oldfield JOURNAL: N Engl J Med. 2015 Aug 27;373(9):792-3. doi: 10.1056/NEJMp1506873. At least twice monthly, I see Ms. F. in the hospital where I'm training. Tall, with olive skin, freckles, and short curly hair, she walks with perfect posture in immaculate sneakers. She's in her late 20s and has moderate(...)

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