Article of the Week

Antimicrobial Access in the 21st Century: Delays and Critical Shortages

Antimicrobial Access in the 21st Century: Delays and Critical Shortages

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ARTICLE: Antimicrobial Access in the 21st Century: Delays and Critical Shortages AUTHORS: Shmuel Shoham, Annukka Antar, Paul Auwaerter, Christine Durand, Mark Sulkowski and Deborah Cotton JOURNAL: Ann Intern Med. 2016 Mar 22. doi: 10.7326/M15-3076. [Epub ahead of print] A young woman with a bone marrow transplant and relapsed leukemia is placed on a regimen of the antibiotic(...)

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Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

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ARTICLE: Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial AUTHORS: Mina C Hosseinipour, Gregory P Bisson, Sachiko Miyahara, Xin Sun, Agnes Moses, Cynthia Riviere, Fredrick K Kirui, Sharlaa Badal-Faesen, David Lagat, Mulinda Nyirenda, Kogieleum Naidoo, James Hakim, Peter Mugyenyi, German Henostroza, Paul(...)

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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

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ARTICLE: Epigenetic modulators, modifiers and mediators in cancer aetiology and progression AUTHORS: Andrew P. Feinberg, Michael A. Koldobskiy, Anita Göndör JOURNAL: Nat Rev Genet. 2016 Mar 14. doi: 10.1038/nrg.2016.13. [Epub ahead of print] Abstract This year is the tenth anniversary of the publication in this journal of a model suggesting the existence of 'tumour progenitor genes'.(...)

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Misanalysis of Urinalysis: A Teachable Moment

Misanalysis of Urinalysis: A Teachable Moment

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ARTICLE: Misanalysis of Urinalysis: A Teachable Moment AUTHORS: Kathryn B. Holroyd, Alexander Rittenberg and Amit Pahwa JOURNAL: JAMA Intern Med. 2016 Mar 7. doi: 10.1001/jamainternmed.2016.0067. [Epub ahead of print] A 64-year-old woman with a history of Bertolotti syndrome causing chronic low back pain presented to the emergency department because she was experiencing medication withdrawal symptoms. She had recently stopped her home(...)

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Validation of the Instant Blood Pressure Smartphone App

Validation of the Instant Blood Pressure Smartphone App

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ARTICLE: Validation of the Instant Blood Pressure Smartphone App AUTHORS: Timothy B. Plante, Bruno Urrea, Zane T. MacFarlane, Roger S. Blumenthal, Edgar R. Miller III, Lawrence J. Appel and Seth S. Martin JOURNAL: JAMA Intern Med. 2016 Mar 2. doi: 10.1001/jamainternmed.2016.0157. [Epub ahead of print] Abstract Mobile health (mHealth) technologies include unregulated consumer smartphone apps.1 The Instant Blood Pressure app (IBP; AuraLife) estimates blood pressure (BP) using a technique in which(...)

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Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

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ARTICLE: Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women AUTHORS: Jared M. Baeten, Thesla Palanee-Phillips, Elizabeth R. Brown, Katie Schwartz, Lydia E. Soto-Torres, Vaneshree Govender, Nyaradzo M. Mgodi, Flavia Matovu Kiweewa, Gonasagrie Nair, Felix Mhlanga, Samantha Siva, Linda-Gail Bekker, Nitesha Jeenarain, Zakir Gaffoor, Francis Martinson, Bonus Makanani, Arendevi Pather, Logashvari Naidoo, Marla Husnik, Barbra A. Richardson, Urvi M. Parikh,(...)

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Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

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ARTICLE: Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease AUTHORS: Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, Grams ME JOURNAL: JAMA Intern Med. 2016 Feb 1;176(2):238-46. doi: 10.1001/jamainternmed.2015.7193 Abstract IMPORTANCE: Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI(...)

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HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial

HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial

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ARTICLE: HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial AUTHORS: Karen T. Tashima, Laura M. Smeaton, Carl J. Fichtenbaum, Adriana Andrade, Joseph J. Eron, Rajesh T. Gandhi, Victoria A. Johnson, Karin L. Klingman, Justin Ritz, Sally Hodder, Jorge L. Santana, Timothy Wilkin and Richard H. Haubrich, on behalf of the A5241(...)

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From Dancing to Debilitated

From Dancing to Debilitated

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ARTICLE: From Dancing to Debilitated AUTHORS: Brian A. Houston, P. Elliott Miller, Lisa M. Rooper, Paul J. Scheel, Jr. and Allan C. Gelber JOURNAL: N Engl J Med. 2016 Feb 4;374(5):470-7. doi: 10.1056/NEJMcps1311794 A 69-year-old man sought care from his primary care physician for fatigue and an unintentional weight loss of 14 kg over the preceding(...)

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Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women

Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women

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ARTICLE: Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women AUTHORS: Jyoti S Mathad, Ramesh Bhosale, Usha Balasubramanian, Savita Kanade, Vidya Mave, Nishi Suryavanshi, Nikhil Gupte, Samir Joshi, Ajay Chandanwale, Kathryn M Dupnik, Vandana Kulkarni, Prasad Deshpande, Daniel W Fitzgerald and Amita Gupta JOURNAL: Am J Respir Crit Care Med. 2016 Jan 14. [Epub ahead of print] Abstract RATIONALE: Pregnant women with latent TB infection (LTBI) are at high risk(...)

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