Article of the Week

Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis

Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis

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ARTICLE: Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis AUTHORS: Allison A. Lambert, Jennifer O. Lam, Julie J. Paik, Cesar Ugarte-Gil, M. Bradley Drummond, Trevor A. Crowell JOURNAL: PLoS One. 2015 Jun 4;10(6):e0128004. doi: 10.1371/journal.pone.0128004. eCollection 2015. Abstract BACKGROUND: Proton-pump inhibitors (PPIs) are among the most frequently prescribed medications.(...)

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Citrullination of myofilament proteins in heart failure

Citrullination of myofilament proteins in heart failure

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ARTICLE: Citrullination of myofilament proteins in heart failure AUTHORS: J. Fert-Bober, J.T. Giles, R.J. Holewinski, J.A. Kirk, H. Uhrigshardt, E.L. Crowgey, F. Andrade, C.O. Bingham 3rd, J.K. Park, M.K. Halushka, D.A. Kass, J.M. Bathon and J.E. Van Eyk JOURNAL: Cardiovasc Res. 2015 Jun 25. pii: cvv185. [Epub ahead of print] Abstract AIM: Citrullination, the post-translational(...)

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Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle

Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle

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ARTICLE: Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle AUTHORS: Genaro A. Ramirez-Correa, Junfeng Ma, Chad Slawson, Quira Zeidan, Nahyr S. Lugo-Fagundo, Mingguo Xu, Xiaoxu Shen, Wei Dong Gao, Viviane Caceres, Khalid Chakir, Lauren DeVine, Robert Cole, Luigi Marchionni, Nazareno Paolocci, Gerald W. Hart and Anne M. Murphy JOURNAL: Diabetes. 2015 Jun(...)

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Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

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ARTICLE: Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart AUTHORS: Gaurav Kaushik, Alice Spenlehauer, Ayla O. Sessions, Adriana S. Trujillo, Alexander Fuhrmann, Zongming Fu, Vidya Venkatraman, Danielle Pohl, Jeremy Tuler, Mingyi Wang, Edward G. Lakatta, Karen Ocorr, Rolf Bodmer, Sanford I. Bernstein, Jennifer E. Van Eyk, Anthony Cammarato and Adam J. Engler(...)

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Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management

Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management

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ARTICLE: Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management AUTHOR: Gordon F. Tomaselli JOURNAL: Circulation Research. June 5, 2015; Vol. 116, No. 12 Overview of Sudden Cardiac Death and Scope of the Compendium Sudden cardiac death (SCD) is a devastating complication of many forms of heart disease and on occasion presents(...)

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Atypical HUS may become a diagnosis of inclusion

Atypical HUS may become a diagnosis of inclusion

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ARTICLE: Atypical HUS may become a diagnosis of inclusion AUTHORS: J. Evan Sadler JOURNAL: Blood. 2015 Jun 4;125(23):3525-6. doi: 10.1182/blood-2015-04-640656 Patients with aHUS usually have microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. However, these features occur in many diseases, including thrombotic thrombocytopenic purpura (TTP), and the more common form of Shiga toxin–expressing Escherichia coli hemolytic(...)

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Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage

Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage

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ARTICLE: Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage AUTHOURS: Yulan Cheng, Ana P. Kiess, Joseph M. Herman, Martin G. Pomper, Stephen J. Meltzer, John M. Abraham JOURNAL: PLoS One. 2015 Jun 1;10(6):e0128152. doi: 10.1371/journal.pone.0128152. eCollection 2015. Abstract Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill(...)

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Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population

Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population

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ARTICLE: Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population AUTHORS: Waseem Khaliq, Rehan Qayyum Jeffrey Clough, Dhananjay Vaidya, Antonio C. Wolff, Diane M. Becker JOURNAL: Breast Cancer Res Treat. 2015 Jun;151(2):465-74. doi: 10.1007/s10549-015-3412-5. Epub  2015 May 10. Abstract Studies have suggested a decreased breast cancer risk(...)

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A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

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ARTICLE: A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury AUTHORS: Matthew T. James, Morgan E. Grams, Mark Woodward, C. Raina Elley, Jamie A. Green, David C. Wheeler, Paul de Jong, Ron T. Gansevoort, Andrew S. Levey, David G. Warnock, Mark J. Sarnak JOURNAL: Am J Kidney(...)

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Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort

Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort

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ARTICLE: Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort AUTHORS: Jason I Feinberg, Kelly M Bakulski, Andrew E Jaffe, Rakel Tryggvadottir, Shannon C Brown, Lynn R Goldman, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, M Daniele Fallin, Andrew P Feinberg JOURNAL: Int J Epidemiol. 2015 Apr 14.(...)

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