Article of the Week

Real cost of outrageous drug prices: Column

Real cost of outrageous drug prices: Column

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ARTICLE: Real cost of outrageous drug prices: Column AUTHORS: Leah Dickstein, Rachel Kruzan and Annie Antar JOURNAL: USA Today In 1996, Reva Jones’ daughter, Tonya, gave her the ultimate gift — a kidney that would save her life. Like all transplant recipients, Reva would have to take medications for the rest of her life to protect(...)

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Pacemaker-induced transient asynchrony suppresses heart failure progression

Pacemaker-induced transient asynchrony suppresses heart failure progression

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ARTICLE: Pacemaker-induced transient asynchrony suppresses heart failure progression AUTHORS: Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA JOURNAL: Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899. Abstract Uncoordinated contraction from electromechanical delay worsens heart failure pathophysiology and prognosis, but restoring coordination with biventricular pacing, known as cardiac resynchronization(...)

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Why I Believe in Hospital at Home

Why I Believe in Hospital at Home

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ARTICLE: Why I Believe in Hospital at Home AUTHOR: Bruce Leff JOURNAL: N Engl Med. 2015 Dec 21 As a medical resident in the late 1980s, I made house calls to homebound older adults in Baltimore. I loved seeing patients and their families in their own space, thinking about their medical issues in that context,(...)

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O-GlcNAcomic profiling identifies widespread O-GlcNAcylation in oxidative phosphorylation system regulating cardiac mitochondrial function

O-GlcNAcomic profiling identifies widespread O-GlcNAcylation in oxidative phosphorylation system regulating cardiac mitochondrial function

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For our final Article of the Week of 2015, we feature a collaborative effort between Brian O’Rourke’s and Gerald Hart’s labs that was recently named one of the Journal of Biological Chemisty’s best of 2015. To see all of the 16 papers to receive this distinction, click here: http://www.jbc.org/content/290/49/29141.long ARTICLE: O-GlcNAcomic profiling identifies widespread O-GlcNAcylation(...)

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Trends in National Institutes of Health Funding for Clinical Trials Registered in ClinicalTrials.gov

Trends in National Institutes of Health Funding for Clinical Trials Registered in ClinicalTrials.gov

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ARTICLE: Trends in National Institutes of Health Funding for Clinical Trials Registered in ClinicalTrials.gov AUTHORS: Ehrhardt S, Appel LJ, Meinert CL JOURNAL: JAMA. 2015 Dec 15;314(23):2566-7. doi: 10.1001/jama.2015.12206 Since 2006, the number of industry-sponsored clinical trials studying the benefits and harms of medical treatments has risen dramatically, while the number of clinical trials funded by the National Institutes of Health (NIH) has fallen substantially, according to new Johns(...)

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Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

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ARTICLE: Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research AUTHORS: Adler RA, Fuleihan GE, Bauer DC, Camacho PM, Clarke BL, Clines GA, Compston JE, Drake MT, Edwards BJ, Favus MJ, Greenspan SL, McKinney R Jr, Pignolo RJ, Sellmeyer DE JOURNAL: J Bone Miner Res. 2015 Sep 9. doi: 10.1002/jbmr.2708. [Epub ahead of print] Abstract Bisphosphonates(...)

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Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

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ARTICLE: Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection AUTHORS: Foster GR, Afdhal N, Roberts SK, Bräu N, Gane EJ, Pianko S, Lawitz E, Thompson A, Shiffman ML, Cooper C, Towner WJ, Conway B, Ruane P, Bourlière M,Asselah T, Berg T, Zeuzem S, Rosenberg W, Agarwal K, Stedman CA, Mo H, Dvory-Sobol H, Han L, Wang J, McNally J, Osinusi A, Brainard DM, McHutchison JG, Mazzotta F, Tran TT, Gordon SC, Patel K, Reau N, Mangia A, Sulkowski M; ASTRAL-2 and ASTRAL-3 Investigators JOURNAL: N Engl J(...)

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Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study

Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study

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ARTICLE: Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study AUTHORS: Chida N, Ansari Z, Hussain H, Jaswal M, Symes S, Khan AJ, Mohammed S JOURNAL: PLoS One. 2015 Nov 12;10(11):e0142384. doi: 10.1371/journal.pone.0142384. eCollection 2015. Abstract PURPOSE: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has(...)

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Graduate Medical Education in the Freddie Gray Era

Graduate Medical Education in the Freddie Gray Era

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ARTICLE: Graduate Medical Education in the Freddie Gray Era AUTHORS: Sammy Zakaria, Erica N. Johnson, Jennifer L. Hayashi and Colleen Christmas JOURNAL: N Engl J Med. 2015 Nov 19;373(21):1998-2000. doi: 10.1056/NEJMp1509216. Abstract In the wake of the death of Freddie Gray and the protests over unjust treatment of black Americans, the internal medicine residency program at(...)

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Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study

Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study

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ARTICLE: Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study AUTHORS: Seamus P. Whelton, Michael G. Silverman, John W. McEvoy, Matthew J. Budoff, Ron Blankstein, John Eng, Roger S. Blumenthal, Moyses Szklo, Khurram Nasir and Michael J. Blaha JOURNAL: J Am Coll Cardiol Img. 2015;():. doi:10.1016/j.jcmg.2015.06.019 Abstract OBJECTIVES: This study sought to determine(...)

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