Article of the Week

Misanalysis of Urinalysis: A Teachable Moment

Misanalysis of Urinalysis: A Teachable Moment

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ARTICLE: Misanalysis of Urinalysis: A Teachable Moment AUTHORS: Kathryn B. Holroyd, Alexander Rittenberg and Amit Pahwa JOURNAL: JAMA Intern Med. 2016 Mar 7. doi: 10.1001/jamainternmed.2016.0067. [Epub ahead of print] A 64-year-old woman with a history of Bertolotti syndrome causing chronic low back pain presented to the emergency department because she was experiencing medication withdrawal symptoms. She had recently stopped her home(...)

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Validation of the Instant Blood Pressure Smartphone App

Validation of the Instant Blood Pressure Smartphone App

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ARTICLE: Validation of the Instant Blood Pressure Smartphone App AUTHORS: Timothy B. Plante, Bruno Urrea, Zane T. MacFarlane, Roger S. Blumenthal, Edgar R. Miller III, Lawrence J. Appel and Seth S. Martin JOURNAL: JAMA Intern Med. 2016 Mar 2. doi: 10.1001/jamainternmed.2016.0157. [Epub ahead of print] Abstract Mobile health (mHealth) technologies include unregulated consumer smartphone apps.1 The Instant Blood Pressure app (IBP; AuraLife) estimates blood pressure (BP) using a technique in which(...)

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Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

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ARTICLE: Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women AUTHORS: Jared M. Baeten, Thesla Palanee-Phillips, Elizabeth R. Brown, Katie Schwartz, Lydia E. Soto-Torres, Vaneshree Govender, Nyaradzo M. Mgodi, Flavia Matovu Kiweewa, Gonasagrie Nair, Felix Mhlanga, Samantha Siva, Linda-Gail Bekker, Nitesha Jeenarain, Zakir Gaffoor, Francis Martinson, Bonus Makanani, Arendevi Pather, Logashvari Naidoo, Marla Husnik, Barbra A. Richardson, Urvi M. Parikh,(...)

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Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

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ARTICLE: Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease AUTHORS: Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, Grams ME JOURNAL: JAMA Intern Med. 2016 Feb 1;176(2):238-46. doi: 10.1001/jamainternmed.2015.7193 Abstract IMPORTANCE: Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI(...)

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HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial

HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial

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ARTICLE: HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial AUTHORS: Karen T. Tashima, Laura M. Smeaton, Carl J. Fichtenbaum, Adriana Andrade, Joseph J. Eron, Rajesh T. Gandhi, Victoria A. Johnson, Karin L. Klingman, Justin Ritz, Sally Hodder, Jorge L. Santana, Timothy Wilkin and Richard H. Haubrich, on behalf of the A5241(...)

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From Dancing to Debilitated

From Dancing to Debilitated

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ARTICLE: From Dancing to Debilitated AUTHORS: Brian A. Houston, P. Elliott Miller, Lisa M. Rooper, Paul J. Scheel, Jr. and Allan C. Gelber JOURNAL: N Engl J Med. 2016 Feb 4;374(5):470-7. doi: 10.1056/NEJMcps1311794 A 69-year-old man sought care from his primary care physician for fatigue and an unintentional weight loss of 14 kg over the preceding(...)

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Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women

Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women

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ARTICLE: Quantitative IFN-γ,IL-2 Response and Latent Tuberculosis Test Discordance in HIV-infected Pregnant Women AUTHORS: Jyoti S Mathad, Ramesh Bhosale, Usha Balasubramanian, Savita Kanade, Vidya Mave, Nishi Suryavanshi, Nikhil Gupte, Samir Joshi, Ajay Chandanwale, Kathryn M Dupnik, Vandana Kulkarni, Prasad Deshpande, Daniel W Fitzgerald and Amita Gupta JOURNAL: Am J Respir Crit Care Med. 2016 Jan 14. [Epub ahead of print] Abstract RATIONALE: Pregnant women with latent TB infection (LTBI) are at high risk(...)

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Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel

Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel

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ARTICLE: Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel AUTHORS: Gupta A, Mathad JS, Abdel-Rahman SM, Albano JD, Botgros R, Brown V, Browning RS, Dawson L, Dooley KE, Gnanashanmugam D, Grinsztejn B,Hernandez-Diaz S, Jean-Philippe P, Kim P, Lyerly AD, Mirochnick M, Mofenson LM, Montepiedra G, Piper J, Sahin L, Savic R, Smith B,Spiegel H, Swaminathan S, Watts DH, White A JOURNAL: Clin Infect Dis. 2015 Dec(...)

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Real cost of outrageous drug prices: Column

Real cost of outrageous drug prices: Column

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ARTICLE: Real cost of outrageous drug prices: Column AUTHORS: Leah Dickstein, Rachel Kruzan and Annie Antar JOURNAL: USA Today In 1996, Reva Jones’ daughter, Tonya, gave her the ultimate gift — a kidney that would save her life. Like all transplant recipients, Reva would have to take medications for the rest of her life to protect(...)

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Pacemaker-induced transient asynchrony suppresses heart failure progression

Pacemaker-induced transient asynchrony suppresses heart failure progression

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ARTICLE: Pacemaker-induced transient asynchrony suppresses heart failure progression AUTHORS: Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA JOURNAL: Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899. Abstract Uncoordinated contraction from electromechanical delay worsens heart failure pathophysiology and prognosis, but restoring coordination with biventricular pacing, known as cardiac resynchronization(...)

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