Article of the Week

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

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ARTICLE: Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research AUTHORS: Adler RA, Fuleihan GE, Bauer DC, Camacho PM, Clarke BL, Clines GA, Compston JE, Drake MT, Edwards BJ, Favus MJ, Greenspan SL, McKinney R Jr, Pignolo RJ, Sellmeyer DE JOURNAL: J Bone Miner Res. 2015 Sep 9. doi: 10.1002/jbmr.2708. [Epub ahead of print] Abstract Bisphosphonates(...)

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Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

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ARTICLE: Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection AUTHORS: Foster GR, Afdhal N, Roberts SK, Bräu N, Gane EJ, Pianko S, Lawitz E, Thompson A, Shiffman ML, Cooper C, Towner WJ, Conway B, Ruane P, Bourlière M,Asselah T, Berg T, Zeuzem S, Rosenberg W, Agarwal K, Stedman CA, Mo H, Dvory-Sobol H, Han L, Wang J, McNally J, Osinusi A, Brainard DM, McHutchison JG, Mazzotta F, Tran TT, Gordon SC, Patel K, Reau N, Mangia A, Sulkowski M; ASTRAL-2 and ASTRAL-3 Investigators JOURNAL: N Engl J(...)

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Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study

Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study

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ARTICLE: Determinants of Default from Tuberculosis Treatment among Patients with Drug-Susceptible Tuberculosis in Karachi, Pakistan: A Mixed Methods Study AUTHORS: Chida N, Ansari Z, Hussain H, Jaswal M, Symes S, Khan AJ, Mohammed S JOURNAL: PLoS One. 2015 Nov 12;10(11):e0142384. doi: 10.1371/journal.pone.0142384. eCollection 2015. Abstract PURPOSE: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has(...)

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Graduate Medical Education in the Freddie Gray Era

Graduate Medical Education in the Freddie Gray Era

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ARTICLE: Graduate Medical Education in the Freddie Gray Era AUTHORS: Sammy Zakaria, Erica N. Johnson, Jennifer L. Hayashi and Colleen Christmas JOURNAL: N Engl J Med. 2015 Nov 19;373(21):1998-2000. doi: 10.1056/NEJMp1509216. Abstract In the wake of the death of Freddie Gray and the protests over unjust treatment of black Americans, the internal medicine residency program at(...)

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Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study

Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study

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ARTICLE: Predictors of Long-Term Healthy Arterial Aging: Coronary Artery Calcium Nondevelopment in the MESA Study AUTHORS: Seamus P. Whelton, Michael G. Silverman, John W. McEvoy, Matthew J. Budoff, Ron Blankstein, John Eng, Roger S. Blumenthal, Moyses Szklo, Khurram Nasir and Michael J. Blaha JOURNAL: J Am Coll Cardiol Img. 2015;():. doi:10.1016/j.jcmg.2015.06.019 Abstract OBJECTIVES: This study sought to determine(...)

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Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate

Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate

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ARTICLE: Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate AUTHORS: Morgan E. Grams, Yingying Sang, Andrew S. Levey, Kunihiro Matsushita, Shoshana Ballew, Alex R. Chang, Eric K.H. Chow, Bertram L. Kasiske, Csaba P. Kovesdy, Girish N. Nadkarni, Varda Shalev, Dorry L. Segev, Josef Coresh, Krista L. Lentine and Amit X. Garg JOURNAL: N Engl J(...)

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Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use

Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use

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ARTICLE: Frailty, Inflammation and Mortality Among Persons Aging With HIV Infection and Injection Drug Use AUTHORS: Piggott DA, Varadhan R, Mehta SH, Brown TT, Li H, Walston JD, Leng SX, Kirk GD JOURNAL: J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1542-1547. Epub 2015 Sep 18. Abstract BACKGROUND: Serum markers of inflammation increase with age and have been strongly associated with adverse(...)

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Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?

Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?

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ARTICLE: Can Antihypertensive Treatment Restore the Risk of Cardiovascular Disease to Ideal Levels?: The Coronary Artery Risk Development in Young Adults (CARDIA) Study and the Multi-Ethnic Study of Atherosclerosis (MESA) AUTHORS: Liu K, Colangelo LA, Daviglus ML, Goff DC, Pletcher M, Schreiner PJ, Sibley CT, Burke GL, Post WS, Michos ED, Lloyd-Jones DM JOURNAL: J Am Heart Assoc. 2015 Sep 21;4(9). pii: e002275. doi: 10.1161/JAHA.115.002275.(...)

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Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment

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ARTICLE: Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment AUTHORS: Chan AT, Karakas MF, Vakrou S, Afzal J, Rittenbach A, Lin X, Wahl RL, Pomper MG, Steenbergen CJ, Tsui BM, Elisseeff JH, Abraham MR JOURNAL: Biomaterials. 2015 Dec;73:1-11. doi: 10.1016/j.biomaterials.2015.09.001. Epub 2015 Sep 4. Abstract BACKGROUND: Cell death due to anoikis, necrosis and cell egress from transplantation sites limits functional benefits(...)

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Genomics: The interloper

Genomics: The interloper

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ARTICLE: Genomics: The interloper AUTHORS: M. Teresa Villanueva JOURNAL: Nat Rev Genet. 2015 Sep 18;16(10):564-5. doi: 10.1038/nrg4009 Article The retrotransposon long interspersed element-1 (LINE-1) is a mobile genetic sequence that can lead to mutagenesis and genetic instability by copying and inserting itself into the genome. LINE-1 insertions have been reported in tumour suppressor genes in several(...)

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