ARTICLE: Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart AUTHORS: Gaurav Kaushik, Alice Spenlehauer, Ayla O. Sessions, Adriana S. Trujillo, Alexander Fuhrmann, Zongming Fu, Vidya Venkatraman, Danielle Pohl, Jeremy Tuler, Mingyi Wang, Edward G. Lakatta, Karen Ocorr, Rolf Bodmer, Sanford I. Bernstein, Jennifer E. Van Eyk, Anthony Cammarato and Adam J. Engler […]
Article of the Week
Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management
Posted by | Article of the WeekARTICLE: Introduction to a compendium on sudden cardiac death: epidemiology, mechanisms and management AUTHOR: Gordon F. Tomaselli JOURNAL: Circulation Research. June 5, 2015; Vol. 116, No. 12 Overview of Sudden Cardiac Death and Scope of the Compendium Sudden cardiac death (SCD) is a devastating complication of many forms of heart disease and on occasion presents […]
Atypical HUS may become a diagnosis of inclusion
Posted by | Article of the WeekARTICLE: Atypical HUS may become a diagnosis of inclusion AUTHORS: J. Evan Sadler JOURNAL: Blood. 2015 Jun 4;125(23):3525-6. doi: 10.1182/blood-2015-04-640656 Patients with aHUS usually have microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. However, these features occur in many diseases, including thrombotic thrombocytopenic purpura (TTP), and the more common form of Shiga toxin–expressing Escherichia coli hemolytic […]
Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage
Posted by | Article of the WeekARTICLE: Phosphorus-32, a Clinically Available Drug, Inhibits Cancer Growth by Inducing DNA Double-Strand Breakage AUTHOURS: Yulan Cheng, Ana P. Kiess, Joseph M. Herman, Martin G. Pomper, Stephen J. Meltzer, John M. Abraham JOURNAL: PLoS One. 2015 Jun 1;10(6):e0128152. doi: 10.1371/journal.pone.0128152. eCollection 2015. Abstract Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill […]
Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population
Posted by | Article of the WeekARTICLE: Comparison of breast cancer risk in women with and without systemic lupus erythematosus in a Medicare population AUTHORS: Waseem Khaliq, Rehan Qayyum Jeffrey Clough, Dhananjay Vaidya, Antonio C. Wolff, Diane M. Becker JOURNAL: Breast Cancer Res Treat. 2015 Jun;151(2):465-74. doi: 10.1007/s10549-015-3412-5. Epub 2015 May 10. Abstract Studies have suggested a decreased breast cancer risk […]
A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury
Posted by | Article of the WeekARTICLE: A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury AUTHORS: Matthew T. James, Morgan E. Grams, Mark Woodward, C. Raina Elley, Jamie A. Green, David C. Wheeler, Paul de Jong, Ron T. Gansevoort, Andrew S. Levey, David G. Warnock, Mark J. Sarnak JOURNAL: Am J Kidney […]
Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort
Posted by | Article of the WeekARTICLE: Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort AUTHORS: Jason I Feinberg, Kelly M Bakulski, Andrew E Jaffe, Rakel Tryggvadottir, Shannon C Brown, Lynn R Goldman, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, M Daniele Fallin, Andrew P Feinberg JOURNAL: Int J Epidemiol. 2015 Apr 14. […]
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
Posted by | Article of the WeekARTICLE: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease AUTHORS: Dong I. Lee, Guangshuo Zhu, Takashi Sasaki, Gun-Sik Cho, Nazha Hamdani, Ronald Holewinski, Su-Hyun Jo, Thomas Danner, Manling Zhang, Peter P. Rainer, Djahida Bedja, Jonathan A. Kirk, Mark J. Ranek, Wolfgang R. Dostmann, Chulan Kwon, Kenneth B. Margulies, Jennifer E. Van Eyk, Walter J. […]
The Johns Hopkins Learning Environment Scale: Measuring Medical Students’ Perceptions of the Processes Supporting Professional Formation
Posted by | Article of the WeekARTICLE: The Johns Hopkins Learning Environment Scale: Measuring Medical Students’ Perceptions of the Processes Supporting Professional Formation AUTHORS: Robert B. Shochet, MD, Jorie M. Colbert-Getz, PhD and Scott M. Wright, MD JOURNAL: Acad Med. 2015 Apr 4. [Epub ahead of print] Abstract PURPOSE: To construct a new measure to assess students’ perceptions of the medical […]