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Medicine Matters

Sharing successes, challenges and daily happenings in the Department of Medicine

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II)

ARTICLE: Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II) AUTHORS: Michelle Petri, Ian N Bruce, Thomas Dörner, Yoshiya Tanaka, Eric… Read More »Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II)

Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones

ARTICLE: Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones AUTHORS: Filippo Dragoni, Abena K Kwaa, Caroline C Traut, Rebecca T Veenhuis, Bezawit… Read More »Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones

MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

ARTICLE: MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival AUTHORS: C Korin Bullen, Alok K Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William… Read More »MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

ARTICLE: Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury AUTHORS: Yumeng Wen, Emily Su, Leyuan Xu, Steven Menez, Dennis G… Read More »Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

ARTICLE: Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis AUTHORS: Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D Leone, Rana Rais, Jonathan D… Read More »Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis